Cardiac Energy Metabolism in Health and Disease

The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Produk Detail:

  • Author : Gary D. Lopaschuk
  • Publisher : Springer
  • Pages : 295 pages
  • ISBN : 1493912275
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKCardiac Energy Metabolism in Health and Disease

Cardiac Energy Metabolism in Health and Disease

Cardiac Energy Metabolism in Health and Disease
  • Author : Gary D. Lopaschuk,Naranjan S. Dhalla
  • Publisher : Springer
  • Release : 22 August 2014
GET THIS BOOKCardiac Energy Metabolism in Health and Disease

The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different

The Scientist's Guide to Cardiac Metabolism

The Scientist's Guide to Cardiac Metabolism
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  • Publisher : Academic Press
  • Release : 04 November 2015
GET THIS BOOKThe Scientist's Guide to Cardiac Metabolism

The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the

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ATP and the Heart
  • Author : Joanne S. Ingwall
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKATP and the Heart

ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events

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  • Author : Thomas Seyfried
  • Publisher : John Wiley & Sons
  • Release : 18 May 2012
GET THIS BOOKCancer as a Metabolic Disease

The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position

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  • Author : Roy S. Gardner,Andrew L. Clark,Henry Dargie
  • Publisher : Oxford University Press
  • Release : 14 July 2011
GET THIS BOOKOxford Textbook of Heart Failure

Written by internationally renowned leaders in their field and relevant to all practicing clinicians, this textbook comprehensively covers all aspects of heart failure, and suggests the optimal evidence-based management for heart failure patients.

Cellular and Molecular Pathobiology of Cardiovascular Disease

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  • Author : Monte Willis,Jonathon W. Homeister,James R. Stone
  • Publisher : Academic Press
  • Release : 23 December 2013
GET THIS BOOKCellular and Molecular Pathobiology of Cardiovascular Disease

Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical

Cardiac Metabolism in Health and Disease

Cardiac Metabolism in Health and Disease
  • Author : Salah Abdel-aleem,James E. Lowe
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKCardiac Metabolism in Health and Disease

This special issue of Molecular and Cellular Biochemistry contains original research papers as well as invited reviews focused in the field of cardiac metabolism and its regulation under normal and disease conditions. These papers cover many areas under intensive and rapid development such as the regulation of fatty acid oxidation in the heart, the role of cardiac glycogen during ischemia, the role of CPT I isoenzymes, the pathophysiology of diabetic cardiomyopathy, cardiac protection through regulation of energy production, the role

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  • Author : Sergej M. Ostojic
  • Publisher : Academic Press
  • Release : 12 November 2020
GET THIS BOOKClinical Bioenergetics

Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in

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  • Author : Matti Weckström,Pasi Tavi
  • Publisher : Springer Science & Business Media
  • Release : 22 December 2007
GET THIS BOOKCardiac Mechanotransduction

This book presents a multidisciplinary approach to cardiac mechanotransduction. The chapters depict the many faces of the topic, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.