Epi Informatics

Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes. Focuses on the discovery of epi-drugs as candidates to be used in therapy including combined therapies Describes new computational methodologies and screening assays utilizing recent and emerging novel structural data Highlights the discovery, development and optimization of epi-probes, which are molecular probes that elucidate epigenetic mechanisms Includes important topics such as computational-guided optimization of epi-hits, virtual screening to identify novel compounds for epigenetic targets, development and mining of epigenetic molecular databases, SAR modeling of screening data and much more

Produk Detail:

  • Author : Jose Medina-Franco
  • Publisher : Academic Press
  • Pages : 440 pages
  • ISBN : 0128028092
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKEpi Informatics

Epi-Informatics

Epi-Informatics
  • Author : Jose Medina-Franco
  • Publisher : Academic Press
  • Release : 24 February 2016
GET THIS BOOKEpi-Informatics

Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate

Applied Chemoinformatics

Applied Chemoinformatics
  • Author : Thomas Engel,Johann Gasteiger
  • Publisher : John Wiley & Sons
  • Release : 05 June 2018
GET THIS BOOKApplied Chemoinformatics

Edited by world-famous pioneers in chemoinformatics, this is a clearly structured and applications-oriented approach to the topic, providing up-to-date and focused information on the wide range of applications in this exciting field. The authors explain methods and software tools, such that the reader will not only learn the basics but also how to use the different software packages available. Experts describe applications in such different fields as structure-spectra correlations, virtual screening, prediction of active sites, library design, the prediction of

Computational Molecular Modelling in Structural Biology

Computational Molecular Modelling in Structural Biology
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 24 August 2018
GET THIS BOOKComputational Molecular Modelling in Structural Biology

Computational Molecular modelling in Structural Biology, Volume 113, the latest release in the Advances in Protein Chemistry and Structural Biology, highlights new advances in the field, with this new volume presenting interesting chapters on charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping, and Computational Methods to Discover Compounds for the Treatment of Chagas Disease. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 24 August 2016
GET THIS BOOKInsights into Enzyme Mechanisms and Functions from Experimental and Computational Methods

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Written by authorities in their respective fields Targeted to a

Enzymes – Mechanisms, Dynamics and Inhibition

Enzymes – Mechanisms, Dynamics and Inhibition
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 21 September 2020
GET THIS BOOKEnzymes – Mechanisms, Dynamics and Inhibition

Enzymes – Mechanisms, Dynamics and Inhibition, Volume 122, the latest release in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting new and interesting chapters on the topics. Each chapter is written by an international board of authors. Provides a targeted approach to a very wide audience of specialists, researchers and students Contains timely chapters written by well-renowned authorities in their field Includes a number of high quality illustrations, figures and

New Approaches for the Discovery of Pharmacologically-Active Natural Compounds

New Approaches for the Discovery of Pharmacologically-Active Natural Compounds
  • Author : José L. Medina-Franco
  • Publisher : MDPI
  • Release : 01 July 2019
GET THIS BOOKNew Approaches for the Discovery of Pharmacologically-Active Natural Compounds

A major source of active compounds, natural products from different sources supply a large variety of molecules that have been approved for clinical use or used as the starting points of optimization programs. This book features nine papers (eight full articles and one review paper) written by more than 45 scientists from around the world. These papers illustrate the development and application of a broad range of computational and experimental techniques applied to natural product research. On behalf of the contributors

Salmon Lice

Salmon Lice
  • Author : Simon Jones,Richard Beamish
  • Publisher : John Wiley & Sons
  • Release : 02 August 2011
GET THIS BOOKSalmon Lice

The salmon louse Lepeophtheirus salmonis is adapted to survive in hostile marine environments of the northern hemisphere, including an ability to parasitize several species of salmon. Salmonids are some of the most economically important and sought after fish for human consumption, and louse parasitism has a significant impact both on cultured and wild fish populations. Salmon Lice is a timely collection of the latest research on the cause and spread of lice infestations and management techniques being designed and implemented

Modern CNS Drug Discovery

Modern CNS Drug Discovery
  • Author : Rudy Schreiber
  • Publisher : Springer Nature
  • Release : 17 June 2021
GET THIS BOOKModern CNS Drug Discovery

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the

Metaheuristics in Machine Learning: Theory and Applications

Metaheuristics in Machine Learning: Theory and Applications
  • Author : Diego Oliva
  • Publisher : Springer Nature
  • Release : 03 December 2021
GET THIS BOOKMetaheuristics in Machine Learning: Theory and Applications

This book is a collection of the most recent approaches that combine metaheuristics and machine learning. Some of the methods considered in this book are evolutionary, swarm, machine learning, and deep learning. The chapters were classified based on the content; then, the sections are thematic. Different applications and implementations are included; in this sense, the book provides theory and practical content with novel machine learning and metaheuristic algorithms. The chapters were compiled using a scientific perspective. Accordingly, the book is

Microbial and Natural Macromolecules

Microbial and Natural Macromolecules
  • Author : Surajit Das,Hirak Ranjan Dash
  • Publisher : Academic Press
  • Release : 15 September 2020
GET THIS BOOKMicrobial and Natural Macromolecules

Microbial and Natural Macromolecules: Synthesis and Applications brings together active scientists and academicians in the field who share updated information and research outcomes from global experts. Microbial macromolecular diversity, molecular composure, genetics, usability of advanced molecular tools and techniques for their study as well as their applicability are discussed with detailed research perspectives. Illustrates fundamental discoveries and methodological advancements Discusses novel functional attributes of macromolecules Updates progress on microbial macromolecular research

Drug Selectivity

Drug Selectivity
  • Author : Norbert Handler,Helmut Buschmann,Raimund Mannhold,Jörg Holenz
  • Publisher : John Wiley & Sons
  • Release : 05 February 2018
GET THIS BOOKDrug Selectivity

The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major

DNA Methyltransferases - Role and Function

DNA Methyltransferases - Role and Function
  • Author : Albert Jeltsch,Renata Z. Jurkowska
  • Publisher : Springer
  • Release : 08 November 2016
GET THIS BOOKDNA Methyltransferases - Role and Function

DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and

Fish Parasites

Fish Parasites
  • Author : Patrick T. K. Woo,Kurt Buchmann
  • Publisher : CABI
  • Release : 03 December 2021
GET THIS BOOKFish Parasites

Focusing on pathobiology and protective strategies against protozoan and metazoan parasites of fish, this book reviews the latest research on important parasites: those that cause financial hardships to the aquaculture industry, have been introduced to new geographical regions through transportation of infected fish, are pathogenic to groups of finfish and detrimental to production, are highly adaptable and not host-specific with worldwide distributions, and that may serve as disease models for studies on other pathogens. It also highlights gaps in the