Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

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  • Author : Alexey Moskalev
  • Publisher : Academic Press
  • Pages : 544 pages
  • ISBN : 012811083X
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKEpigenetics of Aging and Longevity

Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity
  • Author : Alexey Moskalev,Alexander M. Vaiserman
  • Publisher : Academic Press
  • Release : 17 November 2017
GET THIS BOOKEpigenetics of Aging and Longevity

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in

Epigenetics of Aging

Epigenetics of Aging
  • Author : Trygve O. Tollefsbol
  • Publisher : Springer Science & Business Media
  • Release : 11 November 2009
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Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major

Epigenetics of Aging

Epigenetics of Aging
  • Author : Trygve O. Tollefsbol
  • Publisher : Springer
  • Release : 18 November 2009
GET THIS BOOKEpigenetics of Aging

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major

Lifespan

Lifespan
  • Author : David A. Sinclair,Matthew D. LaPlante
  • Publisher : Atria Books
  • Release : 10 September 2019
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A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory

Ageless

Ageless
  • Author : Andrew Steele
  • Publisher : Doubleday
  • Release : 23 March 2021
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“A fascinating look at how scientists are working to help doctors treat not just one disease at a time, but the aging process itself.” —Dr. Sanjay Gupta A startling chronicle by a brilliant young scientist takes us onto the frontiers of the science of aging, and reveals how close we are to an astonishing extension of our life spans and a vastly improved quality of life in our later years. Aging--not cancer, not heart disease--is the true underlying cause of

Biomarkers of Human Aging

Biomarkers of Human Aging
  • Author : Alexey Moskalev
  • Publisher : Springer Nature
  • Release : 13 September 2019
GET THIS BOOKBiomarkers of Human Aging

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts

Handbook of the Biology of Aging

Handbook of the Biology of Aging
  • Author : Matt Kaeberlein,George Martin
  • Publisher : Academic Press
  • Release : 20 August 2015
GET THIS BOOKHandbook of the Biology of Aging

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to

Nutrition, Exercise and Epigenetics: Ageing Interventions

Nutrition, Exercise and Epigenetics: Ageing Interventions
  • Author : Byung Pal Yu
  • Publisher : Springer
  • Release : 11 February 2015
GET THIS BOOKNutrition, Exercise and Epigenetics: Ageing Interventions

This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena. Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing

Longevity Genes

Longevity Genes
  • Author : Gil Atzmon, PhD
  • Publisher : Springer
  • Release : 27 April 2015
GET THIS BOOKLongevity Genes

The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular

Anti-aging Drugs

Anti-aging Drugs
  • Author : Alexander M Vaiserman
  • Publisher : Royal Society of Chemistry
  • Release : 01 February 2017
GET THIS BOOKAnti-aging Drugs

Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points

How and why We Age

How and why We Age
  • Author : Leonard Hayflick
  • Publisher : Unknown Publisher
  • Release : 01 January 1996
GET THIS BOOKHow and why We Age

A cell biologist who has studied the aging process for thirty years answers the big questions about aging, dispels the myths, and discusses the desirability of living longer

Handbook of Models for Human Aging

Handbook of Models for Human Aging
  • Author : P. Michael Conn
  • Publisher : Elsevier
  • Release : 28 April 2011
GET THIS BOOKHandbook of Models for Human Aging

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion

Biological Aging

Biological Aging
  • Author : Trygve O. Tollefsbol
  • Publisher : Springer Science & Business Media
  • Release : 18 September 2021
GET THIS BOOKBiological Aging

The goal of Biological Aging: Methods and Protocols is to present some of the most promising and important tools that are currently used in biological aging research. These tools include established protocols such as aging cell culture as well as many more contemporary approaches such as nuclear transfer, microarray and proteomics technologies and the use of ribozymes in aging research. Collectively, these powerful tools combined with the many other techniques that are presented are rapidly advancing the exciting and expanding

Transgenerational Epigenetics

Transgenerational Epigenetics
  • Author : Trygve Tollefsbol
  • Publisher : Elsevier
  • Release : 02 May 2014
GET THIS BOOKTransgenerational Epigenetics

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms