Epigenetics of Chronic Pain

Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs. Compiles all known information on epigenetic regulation of chronic pain in one volume Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain

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  • Author : Anonim
  • Publisher : Academic Press
  • Pages : 248 pages
  • ISBN : 0128140712
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKEpigenetics of Chronic Pain

Epigenetics of Chronic Pain

Epigenetics of Chronic Pain
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 29 October 2018
GET THIS BOOKEpigenetics of Chronic Pain

Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined,

The Genetics of Pain

The Genetics of Pain
  • Author : Jeffrey Steven Mogil
  • Publisher : International Assn for the Study of Pain
  • Release : 25 May 2022
GET THIS BOOKThe Genetics of Pain

Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying

Epigenetics of Aging

Epigenetics of Aging
  • Author : Trygve O. Tollefsbol
  • Publisher : Springer Science & Business Media
  • Release : 11 November 2009
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Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major

Sensory Nerves

Sensory Nerves
  • Author : Brendan J. Canning,Domenico Spina
  • Publisher : Springer Science & Business Media
  • Release : 05 August 2009
GET THIS BOOKSensory Nerves

The intention of this book is to provide a comprehensive and contemporary review of the biology of sensory nerves. The book is unique, as it comprehensively covers the role of sensory nerves across many therapeutic areas.

Chronic Pain and DNA Methylation in the Mouse Prefrontal Cortex

Chronic Pain and DNA Methylation in the Mouse Prefrontal Cortex
  • Author : Lucas Topham
  • Publisher : Unknown Publisher
  • Release : 25 May 2022
GET THIS BOOKChronic Pain and DNA Methylation in the Mouse Prefrontal Cortex

"Chronic pain is one of the leading causes of disability and reduced quality of life worldwide. As a result of chronic pain, the prefrontal cortex (PFC) undergoes significant structural and functional remodeling, resulting in the loss of grey matter, altered synapse formation, and changes in neurotransmitter and ion channel signalling. These changes are accompanied by widespread alterations in gene expression and can be reversed if pain is attenuated by therapeutic intervention. The combination of widespread changes in gene expression with

The Disease Delusion

The Disease Delusion
  • Author : Dr. Jeffrey S. Bland
  • Publisher : Harper Collins
  • Release : 06 May 2014
GET THIS BOOKThe Disease Delusion

For decades, Dr. Jeffrey Bland has been on the cutting edge of Functional Medicine, which seeks to pinpoint and prevent the cause of illness, rather than treat its symptoms. Managing chronic diseases accounts for three quarters of our total healthcare costs, because we’re masking these illnesses with pills and temporary treatments, rather than addressing their underlying causes, he argues. Worse, only treating symptoms leads us down the path of further illness. In The Disease Delusion, Dr. Bland explains what

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide
  • Author : Yogesh Dwivedi
  • Publisher : CRC Press
  • Release : 25 June 2012
GET THIS BOOKThe Neurobiological Basis of Suicide

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they

Epigenetics of Stress and Stress Disorders

Epigenetics of Stress and Stress Disorders
  • Author : Nagy Youssef
  • Publisher : Academic Press
  • Release : 25 February 2022
GET THIS BOOKEpigenetics of Stress and Stress Disorders

Epigenetics of Stress and Stress Disorders, Volume 31 in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA or gene expression following prolonged stress and/or trauma. Sections introduce both genetic and psychiatric foundations, including modes of epigenetic modification and gene expression that result from stress, as well as the medical knowledge required to understand stress related disorders and resilience. From here, chapters discuss epigenetic research techniques applied in recent studies, including epigenome-wide association studies (EWAS) of PTSD

Epigenetics of the Immune System

Epigenetics of the Immune System
  • Author : Dieter Kabelitz,Jaydeep Bhat
  • Publisher : Academic Press
  • Release : 04 June 2020
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Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune

An Introduction to Pain and its relation to Nervous System Disorders

An Introduction to Pain and its relation to Nervous System Disorders
  • Author : Anna A. Battaglia
  • Publisher : John Wiley & Sons
  • Release : 02 March 2016
GET THIS BOOKAn Introduction to Pain and its relation to Nervous System Disorders

Introduction to Pain and its relation to Nervous System Disorders provides an accessible overview of the latest developments in the science underpinning pain research, including, but not limited to, the physiological, pathological and psychological aspects. This unique book fills a gap in current literature by focussing on the intricate relationship between pain and human nervous system disorders such as Autism, Alzheimer Disease, Parkinson’s Disease, Depression and Multiple Sclerosis. This fully illustrated, colour handbook will help non-experts, including advanced undergraduate

Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics
  • Author : Shuai Li,John Hopper
  • Publisher : Academic Press
  • Release : 31 August 2021
GET THIS BOOKTwin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic

Bonica's Management of Pain

Bonica's Management of Pain
  • Author : Jane C. Ballantyne,Scott M. Fishman,James P. Rathmell
  • Publisher : Lippincott Williams & Wilkins
  • Release : 19 November 2018
GET THIS BOOKBonica's Management of Pain

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. This exhaustively comprehensive edition of the classic Bonica’s Management of Pain, first published 65 years ago, expertly combines the scientific underpinnings of pain with clinical management. Completely revised, it discusses a wide variety of pain conditions—including neuropathic pain, pain due to cancer, and acute pain situations—for adults as well as children.

Pneumopedics And Craniofacial Epigenetics: Biomimetic Oral Appliance Therapy For Pediatric And Adult Sleep Disordered Breathing

Pneumopedics And Craniofacial Epigenetics: Biomimetic Oral Appliance Therapy For Pediatric And Adult Sleep Disordered Breathing
  • Author : G Dave Singh
  • Publisher : World Scientific
  • Release : 05 March 2021
GET THIS BOOKPneumopedics And Craniofacial Epigenetics: Biomimetic Oral Appliance Therapy For Pediatric And Adult Sleep Disordered Breathing

This textbook provides a comprehensive introduction to the novel concepts of pneumopedics and craniofacial epigenetics. Clinically, these mechanisms are delivered through biomimetic oral appliance therapy. The text, therefore, covers both genetics and epigenetics of craniofacial development, as well as growth and development of the craniofacial architecture. Despite being complex subjects, the style of writing allows the general reader to assimilate this information and sets the scene for how these principles might best be utilized. For example, the clinical application of

The Epigenetics of Autoimmunity

The Epigenetics of Autoimmunity
  • Author : Rongxin Zhang
  • Publisher : Academic Press
  • Release : 25 April 2018
GET THIS BOOKThe Epigenetics of Autoimmunity

The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to