Fibroblast Growth Factor 23

Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23. Provides a comprehensive collection of chapters on the diversity of FGF23's actions Highlights truly translational topics, from molecular signaling to physiology and mechanism of disease, discussing cell culture and animal models to study FGF23 Describes FGF23’s potential in the clinical setting as a biomarker or even drug target Presents leaders in the field who cover a wide spectrum of research backgrounds and expertise, including clinical and basic scientists who specialize in diseases, endocrinology, genetics, protein biochemistry, cell biology and physiology

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  • Author : Christian Faul
  • Publisher : Elsevier
  • Pages : 376 pages
  • ISBN : 0128180374
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKFibroblast Growth Factor 23

Fibroblast Growth Factor 23

Fibroblast Growth Factor 23
  • Author : Christian Faul,Kenneth White,Orlando Gutierrez
  • Publisher : Elsevier
  • Release : 06 April 2021
GET THIS BOOKFibroblast Growth Factor 23

Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology

Phosphate Metabolism

Phosphate Metabolism
  • Author : Shaul Massry
  • Publisher : Springer Science & Business Media
  • Release : 21 November 2013
GET THIS BOOKPhosphate Metabolism

We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden,

Current Perspectives in Kidney Diseases

Current Perspectives in Kidney Diseases
  • Author : G. La Manna,C. Ronco
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 23 May 2017
GET THIS BOOKCurrent Perspectives in Kidney Diseases

After years of stagnation, much has been happening in the diagnosis and treatment of kidney diseases. This book contains a comprehensive review of the main developments in AKI, CKD, hemodialysis and kidney transplantation. The section on AKI deals with the key innovations in extracorporeal technologies. The section on nephrology and CKD concentrates on mineral metabolism alterations, restenosis in hemodialytic fistulas, mycophenolate mofetil as an alternative treatment for IgA nephropathy, and the genetics and progression of autosomal dominant polycystic kidney disease.

Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease

Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease
  • Author : Reinhold G. Erben,L. Darryl Quarles
  • Publisher : Frontiers Media SA
  • Release : 05 April 2019
GET THIS BOOKEndocrine and Paracrine Role of FGF23 and Klotho in Health and Disease

αKlotho and fibroblast growth factor-23 (FGF23) were discovered independently about 20 years ago. Since their initial description, a series of exciting discoveries have revealed the important role of endocrine and paracrine FGF23 and αKlotho signaling not only for the physiological regulation of mineral and bone homeostasis, but also for the pathophysiology of diseases such as chronic kidney disease, left ventricular hypertrophy, myocardial infarction, hypertension, and disorders characterized by impaired bone mineralization. The 11 articles compiled in this Research Topic consist of three

Endocrine FGFs and Klothos

Endocrine FGFs and Klothos
  • Author : Makoto Kuro-o
  • Publisher : Springer Science & Business Media
  • Release : 06 March 2012
GET THIS BOOKEndocrine FGFs and Klothos

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the

Translational Endocrinology of Bone

Translational Endocrinology of Bone
  • Author : Gerard Karsenty
  • Publisher : Academic Press
  • Release : 31 December 2012
GET THIS BOOKTranslational Endocrinology of Bone

The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely

Calcium and Bone Disorders in Children and Adolescents

Calcium and Bone Disorders in Children and Adolescents
  • Author : J. Allgrove,N.J. Shaw
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 11 June 2015
GET THIS BOOKCalcium and Bone Disorders in Children and Adolescents

There has been a rapid expansion of knowledge in the field of paediatric calcium and bone disorders over the past twenty years. Advances have been made in the underlying genetic basis for many conditions in conjunction with progress in bone density and geometry imaging and the development of new treatment options. The 2nd revised edition of ‘Calcium and Bone Disorders in Children and Adolescents’ presents up-to-date information on many aspects included in the 1st edition such as the physiology, pathology,

Nutritional Management of Renal Disease

Nutritional Management of Renal Disease
  • Author : Joel D. Kopple,Shaul G Massry,Kamyar Kalantar-Zadeh,Denis Fouque
  • Publisher : Academic Press
  • Release : 08 October 2021
GET THIS BOOKNutritional Management of Renal Disease

Nutritional Management of Renal Disease, Fourth Edition, offers in-depth reviews of the metabolic and nutritional disorders prevalent in patients with renal disease and serves as an in-depth reference source concerning nutrition and kidney disease. This classic translational reference provides correct diagnosis - and therefore correct treatment - of renal, metabolic, and nutritional disorders. Nephrologists, diebetologists, endocrinologists, dieticians, and nutritionists depend on a strong understanding of the molecular basis for the disease. This fourth edition includes thorough new case reports, offering

Fibroblast Growth Factor-23 in Canine Kidney Disease

Fibroblast Growth Factor-23 in Canine Kidney Disease
  • Author : Laura M. Harjes
  • Publisher : Unknown Publisher
  • Release : 17 October 2021
GET THIS BOOKFibroblast Growth Factor-23 in Canine Kidney Disease

Chronic kidney disease (CKD) is associated with hyperphosphatemia, reduced vitamin D metabolite concentrations, and hyperparathyroidism. This syndrome is known as CKD-mineral and bone disorder (CKD-MBD). Recently it has been shown that increased fibroblast growth factor-23 (FGF23) concentration is one of the earliest biomarkers of CKD in people and cats. It is an independent risk factor for both progression of kidney disease and survival time in humans and cats. FGF23 information in healthy and CKD dogs is lacking. The primary objective

Fibroblast Growth Factor-23 as Novel Marker of Phosphate Homeostasis

Fibroblast Growth Factor-23 as Novel Marker of Phosphate Homeostasis
  • Author : Noreen Abbas,Aysha Habib Khan
  • Publisher : LAP Lambert Academic Publishing
  • Release : 10 December 2015
GET THIS BOOKFibroblast Growth Factor-23 as Novel Marker of Phosphate Homeostasis

Fibroblast growth factor 23 (FGF-23), is recently discovered phosphaturic substance. It releases from bone osteocytes and plays a key role in the physiological regulation of phosphate metabolism. Excessive action of FGF23 results in several hypophosphatemic diseases characterized by impaired renal tubular phosphate reabsorption. In contrast, deficient action of FGF23 causes familial hyperphosphatemic tumoral calcinosis with enhanced renal tubular phosphate reabsorption. We carried out this study to gain knowledge about the current status of FGF-23 levels in our population and its relationship

Biology of Growth Factors

Biology of Growth Factors
  • Author : J. E. Kudlow
  • Publisher : Springer Science & Business Media
  • Release : 09 November 2013
GET THIS BOOKBiology of Growth Factors

Growth factors are elaborated to control the growth of cells in such physiological processes as wound healing, tissue regeneration and the immune response. Abnormal production of these growth factors, their receptors or intracellular med!ators of their action may lead to disease states including oncogenesis. This volume will focus on exciting developments in defining the precise molecular lesions that permit the conversion of controlled proliferative signals to neoplasia, on the possible involvement of growth factors in the development of blood

Clinical Aspects of Natural and Added Phosphorus in Foods

Clinical Aspects of Natural and Added Phosphorus in Foods
  • Author : Orlando M. Gutiérrez,Kamyar Kalantar-Zadeh,Rajnish Mehrotra
  • Publisher : Springer
  • Release : 16 May 2017
GET THIS BOOKClinical Aspects of Natural and Added Phosphorus in Foods

This comprehensive reference covers the impact of dietary phosphorus in phosphorus physiology, public health and the pathogenesis of disease. Divided into three parts, the first section is an overview of the history of phosphorus and the regulation of phosphorus homeostasis. The second section focuses on specific matters related to phosphorus in the food supply. Clinical applications of the material presented in the preceding sections are pulled together in the third section - including the importance of both phosphorus excess and

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
  • Author : Anonim
  • Publisher : John Wiley & Sons
  • Release : 06 December 2018
GET THIS BOOKPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

The authoritative reference to bone diseases and disorders of mineral metabolism, revised and updated Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. Since it was first published 30 years ago, the Primer has become the leading reference on the topic. With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information