Fractal Analysis of the Binding and Dissociation Kinetics for Different Analytes on Biosensor Surfaces

Biosensors are finding increasing applications in different areas. Over the last few years the areas where biosensors may be used effectively has increased dramatically. This book like the previous four books on analyte-receptor binding and dissociation kinetics by this author addresses the often neglected area. The kinetics of binding and dissociation in solution to appropriate receptors immobilized on biosensor surfaces occurs under diffusional limitations on structured surfaces. The receptors immobilized on the biosensor surface contribute to the degree of heterogeneity on the sensor chip surface. The fractal analysis examples presented throughout the book provide a convenient means to make quantitative the degree of heterogeneity present on the sensor surface, and relates it to the binding and dissociation rate coefficients. The fractal dimension is a quantitative measure of the degree of heterogeneity present on the biosensor surface. The book emphasizes medially-oriented examples. The detection of disease-related analytes is also emphasized. The intent being that if intractable and insidious diseases are detected earlier, they will be controlled better, eventually leading to a better prognosis. Chapter 3 is a new chapter that emphasizes enhancing the relevant biosensor performance parameters such as sensitivity, stability, selectivity, response time, etc. As usual, as done in previous books by this author, the last chapter provides an update of the economics involved in biosensors, and the difficulties encounters in starting-up a biosensor company. - Modelling of binding and dissociation kinetics of analyte-receptor reactions on biosensor surfaces: provides physical insights into these reactions occurring on biosensor surfaces. Very few researchers even attempt to analyze the kinetics of these types of reactions. - Fractal analysis used to model the binding and dissociation kinetics: original and unique approach. - Economic analysis provided in the last chapter: helps balance the book; besides providing much-needed information not available in the open literature. - Emphasis on improving biosensor performance parameters: helps make biosensors better. - Empahsis on medically-related analytes: helps in prognosis of diseases.

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  • Author : Ajit Sadana
  • Publisher : Elsevier
  • Pages : 372 pages
  • ISBN : 9780080555010
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKFractal Analysis of the Binding and Dissociation Kinetics for Different Analytes on Biosensor Surfaces

Fractal Analysis of the Binding and Dissociation Kinetics for Different Analytes on Biosensor Surfaces

Fractal Analysis of the Binding and Dissociation Kinetics for Different Analytes on Biosensor Surfaces
  • Author : Ajit Sadana,Neeti Sadana
  • Publisher : Elsevier
  • Release : 20 December 2007
GET THIS BOOKFractal Analysis of the Binding and Dissociation Kinetics for Different Analytes on Biosensor Surfaces

Biosensors are finding increasing applications in different areas. Over the last few years the areas where biosensors may be used effectively has increased dramatically. This book like the previous four books on analyte-receptor binding and dissociation kinetics by this author addresses the often neglected area. The kinetics of binding and dissociation in solution to appropriate receptors immobilized on biosensor surfaces occurs under diffusional limitations on structured surfaces. The receptors immobilized on the biosensor surface contribute to the degree of heterogeneity

Binding and Dissociation Kinetics for Different Biosensor Applications Using Fractals

Binding and Dissociation Kinetics for Different Biosensor Applications Using Fractals
  • Author : Ajit Sadana
  • Publisher : Elsevier
  • Release : 08 August 2006
GET THIS BOOKBinding and Dissociation Kinetics for Different Biosensor Applications Using Fractals

The application of biosensors is expanding in different areas. These are portable and convenient devices that permit the rapid, accurate, and reliable detection of analytes of interest present either in the atmosphere or in aqueous or in liquid phases. The detection of glucose levels in blood for the effective management of diabetes is one. Though different biosensors have been designed for an increasing number of applications, the kinetics of binding (and dissociation) of analytes by the receptors on the biosensor

Biosensors: Kinetics of Binding and Dissociation Using Fractals

Biosensors: Kinetics of Binding and Dissociation Using Fractals
  • Author : Ajit Sadana
  • Publisher : Elsevier
  • Release : 17 December 2003
GET THIS BOOKBiosensors: Kinetics of Binding and Dissociation Using Fractals

This title brings to the attention of researchers in the industry, and in academia, the application of fractals to help in modeling the analyte/receptor binding and dissociation kinetics on biosensor surfaces. The work builds on that done in Engineering Biosensors: Kinetics and Design Applications, published by Academic Press in 2002. In particular, more examples are provided of where biosensors may be effectively used. This sequel is extremely timely, given the anticipation that the applications and reliance on biosensors will increase

Fractal Binding and Dissociation Kinetics for Different Biosensor Applications

Fractal Binding and Dissociation Kinetics for Different Biosensor Applications
  • Author : Ajit Sadana
  • Publisher : Elsevier
  • Release : 06 July 2005
GET THIS BOOKFractal Binding and Dissociation Kinetics for Different Biosensor Applications

Biosensors are portable and convenient devices that permit the rapid and reliable analysis of substances. They are increasingly used in healthcare, drug design, environmental monitoring and the detection of biological, chemical, and toxic agents. Fractal Binding and Dissociation Kinetics for Different Biosensor Applications focuses on two areas of expanding biosensor development that include (a) the detection of biological and chemical pathogens in the atmosphere, and (b) biomedical applications, especially in healthcare. The author provides numerous examples of practical uses, particularly

A Fractal Analysis of Chemical Kinetics with Applications to Biological and Biosensor Interfaces

A Fractal Analysis of Chemical Kinetics with Applications to Biological and Biosensor Interfaces
  • Author : Ajit Sadana,Neeti Sadana,Richa Sadana
  • Publisher : Elsevier
  • Release : 31 July 2018
GET THIS BOOKA Fractal Analysis of Chemical Kinetics with Applications to Biological and Biosensor Interfaces

A Fractal Analysis of Chemical Kinetics with Applications to Biological and Biosensor Interfaces analyzes the kinetics of binding and dissociation of different analytes by different biosensor techniques, demonstrating and then comparing each. Emphasis is placed on newer instrumentation techniques, such as SPRi (surface plasmon resonance imaging), and classical techniques, such as SPR (surface plasmon resonance), and finally, DNA biosensors and nanobiosensors. In addition, a final capstone chapter includes biosensor economics. These topics are all covered in one comprehensive book in

Handbook of Biosensors and Biosensor Kinetics

Handbook of Biosensors and Biosensor Kinetics
  • Author : Ajit Sadana,Neeti Sadana
  • Publisher : Elsevier
  • Release : 26 August 2010
GET THIS BOOKHandbook of Biosensors and Biosensor Kinetics

Biosensors are essential to an ever-expanding range of applications, including healthcare; drug design; detection of biological, chemical, and toxic agents; environmental monitoring; biotechnology; aviation; physics; oceanography; and the protection of civilian and engineering infrastructures. This book, like the previous five books on biosensors by this author (and one by the co-author), addresses the neglected areas of analyte-receptor binding and dissociation kinetics occurring on biosensor surfaces. Topics are covered in a comprehensive fashion, with homogeneous presentation for the benefit of the

Biomarkers and Biosensors

Biomarkers and Biosensors
  • Author : Ajit Sadana,Neeti Sadana
  • Publisher : Newnes
  • Release : 08 December 2014
GET THIS BOOKBiomarkers and Biosensors

Biomarkers and Biosensors offers thorough coverage of biomarker/biosensor interaction, current research trends, and future developments in applications of drug discovery. This book is useful to researchers in this field as well as clinicians interested in new developments in early detection and diagnosis of disease or the mode of operation of biomarkers. Biomarkers and Biosensors also emphasizes kinetics, and clearly delineates how this influences the biomarker market. Offers thorough coverage of the kinetics of biomarker interaction with the biosensor surface

Disposable Electrochemical Sensors for Healthcare Monitoring

Disposable Electrochemical Sensors for Healthcare Monitoring
  • Author : A Pandikumar,K S Shalini Devi
  • Publisher : Royal Society of Chemistry
  • Release : 29 April 2021
GET THIS BOOKDisposable Electrochemical Sensors for Healthcare Monitoring

Disposable electrodes have been widely used as a sensing platform in electrical and electrochemical sensors owing to the possibility of quantitative detection using clinical biomarkers with high precision, sensitivity and reproducibility, which are necessary for accurate diagnosis of the health condition of an individual. This book focusses on the emerging disposable electrochemical sensors in the health sector and the advancement of analytical devices to monitor diabetic, cancer and cardiovascular patients using different nanomaterials. It discusses the upcoming strategies, advantages and

Methods for Affinity-Based Separations of Enzymes and Proteins

Methods for Affinity-Based Separations of Enzymes and Proteins
  • Author : Munishwar N. Gupta
  • Publisher : Springer Science & Business Media
  • Release : 01 April 2002
GET THIS BOOKMethods for Affinity-Based Separations of Enzymes and Proteins

One major concern of biotechnology is either using enzymes or producing them. Enzyme/protein production is therefore an important starting point for biotechnology. Bioseparation or Downstream Processing constitutes about 40-90% of the total production cost. Driven by economics, highly selective technologies applicable to large-scale processing have emerged during the last decade. These technologies are slowly diffusing to enzymologists who are working on a smaller scale, looking for fast and efficient purification protocols. The affinity-based techniques (including precipitation, two-phase extractions, expanded

Engineering Biosensors

Engineering Biosensors
  • Author : Ajit Sadana
  • Publisher : Academic Press
  • Release : 04 October 2001
GET THIS BOOKEngineering Biosensors

Biosensors are becoming increasingly important bioanalytical tools in the pharmaceutical, biotechnology, food, and other consumer oriented industries. The technology, though well developed in Europe, is slowly developing and has begun to generate interest in the United States only over the past couple of years. Research is now being directed toward the development of biosensors that are versatile, economical, and simple to use. Engineering Biosensors is a comprehensive introduction to biosensors that includes numerous illustrations to further explain the main concepts

Recognition Receptors in Biosensors

Recognition Receptors in Biosensors
  • Author : Mohammed Zourob
  • Publisher : Springer Science & Business Media
  • Release : 08 January 2010
GET THIS BOOKRecognition Receptors in Biosensors

Recognition receptors play a key role in the successful implementation of chemical and biosensors. Molecular recognition refers to non-covalent speci?c binding between molecules, one of which is typically a macromolecule or a molecular assembly, and the other is the target molecule (ligand or analyte). Biomolecular recognition is typically driven by many weak interactions such as hydrogen bo- ing, metal coordination, hydrophobic forces, van der Waals forces, pi-pi interactions and electrostatic interaction (due to permanent charges, dipoles, and quadrupoles) the

Sensor Systems for Biological Agent Attacks

Sensor Systems for Biological Agent Attacks
  • Author : National Research Council,Division on Engineering and Physical Sciences,Board on Manufacturing and Engineering Design,Committee on Materials and Manufacturing Processes for Advanced Sensors
  • Publisher : National Academies Press
  • Release : 11 December 2005
GET THIS BOOKSensor Systems for Biological Agent Attacks

Over the last ten years, there has been growing concern about potential biological attacks on the nation’s population and its military facilities. It is now possible to detect such attacks quickly enough to permit treatment of potential victims prior to the onset of symptoms. The capability to “detect to warnâ€, that is in time to take action to minimize human exposure, however, is still lacking. To help achieve such a capability, the Defense Threat Reduction Agency (DTRA) asked the

Biosensors for the Environmental Monitoring of Aquatic Systems

Biosensors for the Environmental Monitoring of Aquatic Systems
  • Author : Damià Barceló,Peter-Dietrich Hansen
  • Publisher : Springer
  • Release : 27 May 2009
GET THIS BOOKBiosensors for the Environmental Monitoring of Aquatic Systems

sector. This ensured eventual transfer of the technology demonstrated at the wo- shops and Technical Meetings to marketable devices. BIOSET provided assistance for researchers from European laboratories to meet to exchange ideas, use equ- ment, and establish a basis for new joint projects. The secretariat of the Concerted Action BIOSET supported the Technical Meetings. There were three Technical Meetings held, two in Berlin in 1997 and 1998, and the third in Barcelona, in April 2000. The goal of these technical meetings was to