Gap Junctions in the Brain

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants. Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants

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  • Author : Ekrem Dere
  • Publisher : Academic Press
  • Pages : 304 pages
  • ISBN : 0124159273
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKGap Junctions in the Brain

Gap Junctions in the Brain

Gap Junctions in the Brain
  • Author : Ekrem Dere
  • Publisher : Academic Press
  • Release : 12 December 2012
GET THIS BOOKGap Junctions in the Brain

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human

Gap Junctions in the Nervous System

Gap Junctions in the Nervous System
  • Author : David C. Spray,Rolf Dermietzel
  • Publisher : Springer Science & Business Media
  • Release : 29 June 2013
GET THIS BOOKGap Junctions in the Nervous System

This book deals with the types of gap junction proteins (connexins) and their distribution within the nervous system, the physiological properties of channels formed of each connexin, and the role of gap junction channels in functions of normal and pathological brain and peripheral nerve. Although glial tissue is emphasized, additional groups of chapters deal with neurons in the central nervous system and with the retina.

Gap Junctions in the Brain

Gap Junctions in the Brain
  • Author : Ekrem Dere
  • Publisher : Academic Press
  • Release : 28 October 2021
GET THIS BOOKGap Junctions in the Brain

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human

Gap Junctions in the Nervous System

Gap Junctions in the Nervous System
  • Author : David C. Spray,Rolf Dermietzel
  • Publisher : Springer
  • Release : 13 November 2013
GET THIS BOOKGap Junctions in the Nervous System

A Cytoplasm Connexon or Hemichannel Cytoplasm external loop I - P. M. N-Termlnus Fig. 1. 1. Topology of gap junction channels. (A) Cap junction channels, extending from the cytoplasm of one cell to the cytoplasm of another, are formed by two connexons or hemichannels connected across extracellular space. (B) Each connexon is formed from six connexin subunits, each having four membrane-spanning domains and both amino and carboxyl termini within the cytoplasm. External/oops (I and II} are believed to provide the high

Connexins

Connexins
  • Author : Andrew Harris,Darren Locke
  • Publisher : Springer Science & Business Media
  • Release : 09 November 2008
GET THIS BOOKConnexins

Connexins: A Guide is a practical and valuable reference and text covering a wide scope of information about the connexin family of membrane channel proteins. The editors and contributing authors intend for this cutting-edge work to be informative to scientists wishing to learn about the field, as well as to those who are active researchers in this area. Connexins: A Guide masterfully addresses specific needs of the scientific community; it is a comprehensive and comprehensible narrative of the uncommonly diverse

Gap Junction Channels and Hemichannels

Gap Junction Channels and Hemichannels
  • Author : Donglin Bai,Juan C. Sáez
  • Publisher : CRC Press
  • Release : 05 August 2016
GET THIS BOOKGap Junction Channels and Hemichannels

Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and hemichannel research has recently exploded and became one of the most active areas of cell biology. Numerous novel approaches and techniques have been developed, but there is no single book dedicated to the unique

Neuroglia

Neuroglia
  • Author : Helmut Kettenmann,Bruce R. Ransom
  • Publisher : Oxford University Press
  • Release : 28 October 2021
GET THIS BOOKNeuroglia

Graduate students in neuroanatomy, neurochemistry, neurophysiology, and molecular neurobiology will find the book indispensable. It is also a vital companion for researchers in these fields as well as clinicians in neurology, neurosurgery, neuropathology, neuro-oncology, physiatry, and psychiatry."--BOOK JACKET.

Microcircuits

Microcircuits
  • Author : Sten Grillner,Ann M. Graybiel
  • Publisher : MIT Press
  • Release : 28 October 2021
GET THIS BOOKMicrocircuits

Leading neuroscientists discuss the function of microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior. Microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior, could provide the link between neurons and global brain function. Microcircuits are designed to serve particular functions; examples of these functional modules include the cortical columns in sensory cortici, glomeruli in the olfactory systems of insects and vertebrates, and networks generating different

Astrocytes and Epilepsy

Astrocytes and Epilepsy
  • Author : Jacqueline A. Hubbard,Devin K. Binder
  • Publisher : Academic Press
  • Release : 05 July 2016
GET THIS BOOKAstrocytes and Epilepsy

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of

Angiogenesis in Brain Tumors

Angiogenesis in Brain Tumors
  • Author : Matthias Kirsch,Peter McL. Black
  • Publisher : Springer Science & Business Media
  • Release : 29 February 2004
GET THIS BOOKAngiogenesis in Brain Tumors

- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field