Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

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  • Author : Rajesh V. Thakker
  • Publisher : Academic Press
  • Pages : 878 pages
  • ISBN : 0128041986
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKGenetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease
  • Author : Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
  • Publisher : Academic Press
  • Release : 31 October 2017
GET THIS BOOKGenetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint,

Basic and Applied Bone Biology

Basic and Applied Bone Biology
  • Author : David B. Burr,Matthew R. Allen
  • Publisher : Academic Press
  • Release : 11 June 2013
GET THIS BOOKBasic and Applied Bone Biology

This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically

Encyclopedia of Bone Biology

Encyclopedia of Bone Biology
  • Author : Mone Zaidi
  • Publisher : Academic Press
  • Release : 14 July 2020
GET THIS BOOKEncyclopedia of Bone Biology

Encyclopedia of Bone Biology covers hot topics from within the rapidly expanding field of bone biology and skeletal research, enabling a complete understanding of both bone physiology and its relation to other organs and pathophysiology. This encyclopedia will serve as a vital resource for those involved in bone research, research in other fields that cross link with bone, such as metabolism and immunology, and physicians who treat bone diseases. Each article provides a comprehensive overview of the selected topic to

Calcium and Bone Disorders in Children and Adolescents

Calcium and Bone Disorders in Children and Adolescents
  • Author : J. Allgrove,N.J. Shaw
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 11 June 2015
GET THIS BOOKCalcium and Bone Disorders in Children and Adolescents

There has been a rapid expansion of knowledge in the field of paediatric calcium and bone disorders over the past twenty years. Advances have been made in the underlying genetic basis for many conditions in conjunction with progress in bone density and geometry imaging and the development of new treatment options. The 2nd revised edition of ‘Calcium and Bone Disorders in Children and Adolescents’ presents up-to-date information on many aspects included in the 1st edition such as the physiology, pathology,

Advances in Pathobiology and Management of Paget’s Disease of Bone

Advances in Pathobiology and Management of Paget’s Disease of Bone
  • Author : Sakamuri V. Reddy
  • Publisher : Academic Press
  • Release : 28 April 2016
GET THIS BOOKAdvances in Pathobiology and Management of Paget’s Disease of Bone

Advances in Pathobiology and Management of Paget’s Disease of Bone presents an essential collection of up-to-date knowledge about the pathophysiology, genetics, and treatment of Paget’s disease. It covers the comprehensive information related to clinical perspectives, epidemiology, genetics, environmental factors such as viral etiology, molecular abnormalities, complications such as osteosarcoma, and current and future treatment for Paget’s disease. This book serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology,

Metabolic Bone Disease and Clinically Related Disorders

Metabolic Bone Disease and Clinically Related Disorders
  • Author : Louis V. Avioli,Stephen M. Krane
  • Publisher : Academic Press
  • Release : 08 October 1997
GET THIS BOOKMetabolic Bone Disease and Clinically Related Disorders

Metabolic Bone Disease, Third Edition is the new, expanded edition of the classic text, featuring the latest advancements and research information in this fast-moving field. The Third Edition includes the most up-to-date information on molecular mechanisms, basic biology, pathophysiology, and diagnosis and management strategies of metabolic bone disease. Key Features * Edited by "fathers of the field" * An expanded version of a classic AP text * Complete coverage of a fast-growing field

Cellular and Molecular Biology of Bone

Cellular and Molecular Biology of Bone
  • Author : Masaki Noda
  • Publisher : Academic Press
  • Release : 28 June 2014
GET THIS BOOKCellular and Molecular Biology of Bone

Written by well-known experts in their respective fields, this book synthesizes recent work on the biology of bone cells at the molecular level. Cellular and Molecular Biology of Bone covers the differentiation of these cells, the regulation of their growth and metabolism, and their death resorption. The authors' special comprehensive treatment of the cellular and molecular mechanisms of bone metabolism makes this book a unique and valuable tool. Cellular and Molecular Biology of Bone provides interested readers-with concise state-of-the-art reviews

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
  • Author : Anonim
  • Publisher : John Wiley & Sons
  • Release : 06 December 2018
GET THIS BOOKPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

The authoritative reference to bone diseases and disorders of mineral metabolism, revised and updated Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. Since it was first published 30 years ago, the Primer has become the leading reference on the topic. With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information

Dynamics of Bone and Cartilage Metabolism

Dynamics of Bone and Cartilage Metabolism
  • Author : Markus J. Seibel,Simon P. Robins,John P. Bilezikian
  • Publisher : Elsevier
  • Release : 24 July 2006
GET THIS BOOKDynamics of Bone and Cartilage Metabolism

This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. Part I

ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
  • Author : Anonim
  • Publisher : John Wiley & Sons
  • Release : 22 December 2009
GET THIS BOOKASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for

The Bioarchaeology of Metabolic Bone Disease

The Bioarchaeology of Metabolic Bone Disease
  • Author : Megan Brickley,Rachel Ives
  • Publisher : Elsevier
  • Release : 26 July 2010
GET THIS BOOKThe Bioarchaeology of Metabolic Bone Disease

The Bioarchaeology of Metabolic Bone Disease provides a comprehensive and invaluable source of information on this important group of diseases. It is an essential guide for those engaged in either basic recording or in-depth research on human remains from archaeological sites. The range of potential tools for investigating metabolic diseases of bone are far greater than for many other conditions, and building on clinical investigations, this book will consider gross, surface features visible using microscopic examination, histological and radiological features

Principles of Bone Biology

Principles of Bone Biology
  • Author : John P. Bilezikian,Lawrence G. Raisz,T. John Martin
  • Publisher : Academic Press
  • Release : 29 September 2008
GET THIS BOOKPrinciples of Bone Biology

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is

Bone Dysplasias

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  • Author : Jürgen W. Spranger,Paula W. Brill,Christine Hall,Gen Nishimura,Andrea Superti-Furga,Sheila Unger
  • Publisher : Oxford University Press
  • Release : 25 October 2018
GET THIS BOOKBone Dysplasias

The definitive guide to genetic bone disorders, now revised and expanded with glossy photographs and radiographs "Brilliantly written and produced and deserves to be on the shelves of all pediatric radiologists. It should also be available to geneticists, counselors, and pediatricians." --Radiology This updated and expanded fourth edition of Bone Dysplasias presents age-related radiographs, photographs and clinical guidelines for more than 250 rare constitutional skeletal diseases. Focusing on diagnostically essential imaging and clinical features, each chapter is supplemented with prognostic and

Principles of Bone Biology

Principles of Bone Biology
  • Author : John P. Bilezikian,Lawrence G. Raisz,Gideon A. Rodan
  • Publisher : Academic Press
  • Release : 19 January 2002
GET THIS BOOKPrinciples of Bone Biology

Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes