Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

Produk Detail:

  • Author : Anonim
  • Publisher : Academic Press
  • Pages : 288 pages
  • ISBN : 0128178205
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKGenome Plasticity in Health and Disease

Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 08 April 2020
GET THIS BOOKGenome Plasticity in Health and Disease

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors,

Skeletal Muscle Plasticity in Health and Disease

Skeletal Muscle Plasticity in Health and Disease
  • Author : Roberto Bottinelli,Carlo Reggiani
  • Publisher : Springer Science & Business Media
  • Release : 08 May 2007
GET THIS BOOKSkeletal Muscle Plasticity in Health and Disease

The ability of striated muscle tissue to adapt to changes in activity or in working conditions is extremely high. In some ways it is comparable to the ability of the brain to learn. The interest in muscle adaptation is increasing in relation to the idea that physical fitness helps in the prevention of disease, may counteract the loss of physical performance and generally improves wellbeing. Plasticity is the word used since the late 1970’s to indicate collectively all the processes

Human Retrotransposons in Health and Disease

Human Retrotransposons in Health and Disease
  • Author : Gael Cristofari
  • Publisher : Springer
  • Release : 06 January 2017
GET THIS BOOKHuman Retrotransposons in Health and Disease

This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as

Myeloid Cells in Health and Disease

Myeloid Cells in Health and Disease
  • Author : Siamon Gordon
  • Publisher : John Wiley & Sons
  • Release : 10 July 2020
GET THIS BOOKMyeloid Cells in Health and Disease

The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis,

Memory Mechanisms in Health and Disease

Memory Mechanisms in Health and Disease
  • Author : Karl Peter Giese
  • Publisher : World Scientific
  • Release : 25 February 2021
GET THIS BOOKMemory Mechanisms in Health and Disease

Memory Mechanisms is an edited review volume that summarizes state-of-the-art knowledge on memory mechanisms at the molecular, cellular and circuit level. Each review is written by leading experts in the field, presenting not only current knowledge, but also discussing the concepts, providing critical reflections and suggesting an outlook for future studies. The memory mechanisms are also discussed in the context of diseases. Studies of memory deficits in disease models are introduced as well as approaches to restore memory deficits. Finally,

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry
  • Author : Thomas Lehner,Bruce L. Miller,Matthew W. State
  • Publisher : Academic Press
  • Release : 07 June 2016
GET THIS BOOKGenomics, Circuits, and Pathways in Clinical Neuropsychiatry

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease
  • Author : Michel Neidhart
  • Publisher : Academic Press
  • Release : 11 August 2015
GET THIS BOOKDNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as

Cellular Endocrinology in Health and Disease

Cellular Endocrinology in Health and Disease
  • Author : Alfredo Ulloa-Aguirre,Ya-Xiong Tao
  • Publisher : Academic Press
  • Release : 15 February 2021
GET THIS BOOKCellular Endocrinology in Health and Disease

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also

Modern Nutrition in Health and Disease

Modern Nutrition in Health and Disease
  • Author : Shils,Olson, K Toby R L,Ross, P.
  • Publisher : Lippincott Williams & Wilkins
  • Release : 25 February 1999
GET THIS BOOKModern Nutrition in Health and Disease

New edition of a text that reviews the history, scientific base, and practice of nutrition for students, practitioners, and educators. One hundred fifteen chapters discuss specific dietary components, nutrition in integrated biologic systems, dietary and nutritional assessment of the individual, prevention and management of disease, diet and nutrition in health of populations, and adequacy, safety, and oversight of the food supply. The appendix includes dietary reference recommendations, anthropometric tables, nutrient and nonnutrient contents, therapeutic diets and exchange lists, and other

Evolution in Health and Disease

Evolution in Health and Disease
  • Author : Stephen C. Stearns,Jacob C. Koella
  • Publisher : Oxford University Press
  • Release : 25 February 2021
GET THIS BOOKEvolution in Health and Disease

A fully revised edition of a volume written by the world's leading authorities on this subject. It discusses how the evolution of humans and their pathogens have generated important medical issues, covering both infectious and degenerative diseases. It presents important ideas that are not yet sufficiently appreciated in the medical community.