Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

Produk Detail:

  • Author : Anonim
  • Publisher : Academic Press
  • Pages : 288 pages
  • ISBN : 0128178205
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKGenome Plasticity in Health and Disease

Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 08 April 2020
GET THIS BOOKGenome Plasticity in Health and Disease

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors,

Epigenomics in Health and Disease

Epigenomics in Health and Disease
  • Author : Mario Fraga,Agustin Fernandez Fernandez
  • Publisher : Academic Press
  • Release : 12 October 2015
GET THIS BOOKEpigenomics in Health and Disease

Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and

Human Retrotransposons in Health and Disease

Human Retrotransposons in Health and Disease
  • Author : Gael Cristofari
  • Publisher : Springer
  • Release : 06 January 2017
GET THIS BOOKHuman Retrotransposons in Health and Disease

This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as

Tandem Repeat Polymorphisms

Tandem Repeat Polymorphisms
  • Author : Anthony J. Hannan
  • Publisher : Springer Science & Business Media
  • Release : 30 July 2013
GET THIS BOOKTandem Repeat Polymorphisms

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various

Goldman-Cecil Medicine E-Book

Goldman-Cecil Medicine E-Book
  • Author : Lee Goldman,Andrew I. Schafer
  • Publisher : Elsevier Health Sciences
  • Release : 16 August 2019
GET THIS BOOKGoldman-Cecil Medicine E-Book

To be the best doctor you can be, you need the best information. For more than 90 years, what is now called Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as

Explaining Health Across the Sciences

Explaining Health Across the Sciences
  • Author : Jonathan Sholl,Suresh I.S. Rattan
  • Publisher : Springer Nature
  • Release : 28 August 2020
GET THIS BOOKExplaining Health Across the Sciences

This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific

Imaging and monitoring astrocytes in health and disease

Imaging and monitoring astrocytes in health and disease
  • Author : Carole Escartin, Keith Murai
  • Publisher : Frontiers Media SA
  • Release : 25 November 2014
GET THIS BOOKImaging and monitoring astrocytes in health and disease

Astrocytes are key cellular partners to neurons in the brain. They play an important role in multiple processes such as neurotransmitter recycling, trophic support, antioxidant defense, ionic homeostasis, inflammatory modulation, neurovascular and neurometabolic coupling, neurogenesis, synapse formation and synaptic plasticity. In addition to their crucial involvement in normal brain physiology, it is well known that astrocytes adopt a reactive phenotype under most acute and chronic pathological conditions such as ischemia, trauma, brain cancer, epilepsy, demyelinating and neurodegenerative diseases. However, the

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 26 August 2020
GET THIS BOOKQuadruplex Nucleic Acids As Targets For Medicinal Chemistry

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Annual Reports in Medicinal Chemistry series

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease
  • Author : Michel Neidhart
  • Publisher : Academic Press
  • Release : 11 August 2015
GET THIS BOOKDNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury
  • Author : Daniel Laskowitz,Gerald Grant
  • Publisher : CRC Press
  • Release : 01 December 2015
GET THIS BOOKTranslational Research in Traumatic Brain Injury

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps

Epigenetics of Lifestyle

Epigenetics of Lifestyle
  • Author : Marcelina Párrizas,Rosa Gasa,Perla Kaliman
  • Publisher : Bentham Science Publishers
  • Release : 07 September 2012
GET THIS BOOKEpigenetics of Lifestyle

Recent advances in the fields of genomics and bioinformatics have made it increasingly clear that genetic sequence alone cannot explain how the genome regulates the development and function of complex multicellular organisms both in health and disease. This inference has led to the expansion of epigenetics as a discipline. Epigenetics refers to the way in which the environment in the wide sense participates in the regulation of gene expression. Several studies show that the well-known beneficial role of a healthy

Applications of Gene-Based Technologies for Improving Animal Production and Health in Developing Countries

Applications of Gene-Based Technologies for Improving Animal Production and Health in Developing Countries
  • Author : Harinder P.S. Makkar,Gerrit J. Viljoen
  • Publisher : Springer Science & Business Media
  • Release : 27 December 2005
GET THIS BOOKApplications of Gene-Based Technologies for Improving Animal Production and Health in Developing Countries

Modern Biotechnology has potential for solving many problems associated with animal productivity and health and offers exciting opportunities for enhancing agricultural productivity. At present the focus is, however, on the issues and problems of significance for livestock producers in the developed world. In order to fully realize the benefits of this technology in developing countries, there is a need to identify, characterize and apply appropriate gene-based technologies for these regions. These proceedings present peer reviewed state-of-the-art papers describing the achievements