Genome Stability

Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. Genome Stability covers a wide range of topics, including the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes and mammals. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability as well as changes in genome stability in response to aging. Finally, Genome Stability covers how epigenetic factors contribute to genome stability and how the species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly-expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effects Provides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability and its effect on human diseases Explains how various species maintain the fine balance in genome stability and genome diversification in response to their environments

Produk Detail:

  • Author : Igor Kovalchuk
  • Publisher : Academic Press
  • Pages : 712 pages
  • ISBN : 0128033452
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKGenome Stability

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher : Academic Press
  • Release : 03 September 2016
GET THIS BOOKGenome Stability

Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments.

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Science
  • Release : 16 December 2013
GET THIS BOOKGenome Stability

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher : Academic Press
  • Release : 03 September 2016
GET THIS BOOKGenome Stability

Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments.

Ubiquitination Governing DNA Repair

Ubiquitination Governing DNA Repair
  • Author : Effrossyni Boutou,Horst-Werner Stürzbecher
  • Publisher : BoD – Books on Demand
  • Release : 01 August 2018
GET THIS BOOKUbiquitination Governing DNA Repair

DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in

Genome Stability and Human Diseases

Genome Stability and Human Diseases
  • Author : Heinz-Peter Nasheuer
  • Publisher : Springer Science & Business Media
  • Release : 11 December 2009
GET THIS BOOKGenome Stability and Human Diseases

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Science
  • Release : 16 December 2013
GET THIS BOOKGenome Stability

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An

Human Papillomavirus Oncoproteins Alter Genomic Stability and Regulate the Viral Life Cycle

Human Papillomavirus Oncoproteins Alter Genomic Stability and Regulate the Viral Life Cycle
  • Author : Jennifer Teresa Thomas
  • Publisher : Unknown Publisher
  • Release : 27 February 1999
GET THIS BOOKHuman Papillomavirus Oncoproteins Alter Genomic Stability and Regulate the Viral Life Cycle

Understanding how human papillomaviruses (HPVs) induce the proliferative lesions associated with genital warts and cervical cancers relies on our appreciation of the functions of the E6 and E7 viral proteins. These "oncoproteins" of the high risk HPV types interfere with the activities of cellular tumor suppressor proteins; E7 proteins act by associating with members of the retinoblastoma family, while E6 increases the turnover of p53. This work describes studies which (1) demonstrate that E6 and E7 alter cell cycle control and

Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer

Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer
  • Author : Tammy A. Morrish,Jose Luis García Pérez
  • Publisher : Frontiers Media SA
  • Release : 16 January 2018
GET THIS BOOKMobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer

The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (

Genome Instability

Genome Instability
  • Author : Marco Muzi-Falconi,Grant W Brown
  • Publisher : Humana Press
  • Release : 20 October 2017
GET THIS BOOKGenome Instability

This volume presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and

Pluripotent Stem Cells

Pluripotent Stem Cells
  • Author : Minoru Tomizawa
  • Publisher : BoD – Books on Demand
  • Release : 20 July 2016
GET THIS BOOKPluripotent Stem Cells

Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine.

Somatic Genome Variation

Somatic Genome Variation
  • Author : Xiu-Qing Li
  • Publisher : John Wiley & Sons
  • Release : 20 April 2017
GET THIS BOOKSomatic Genome Variation

Written by an international team of experts, Somatic Genome Variation presents a timely summary of the latest understanding of somatic genome development and variation in plants, animals, and microorganisms. Wide-ranging in coverage, the authors provide an updated view of somatic genomes and genetic theories while also offering interpretations of somatic genome variation. The text provides geneticists, bioinformaticians, biologist, plant scientists, crop scientists, and microbiologists with a valuable overview of this fascinating field of research.

Ageing: Lessons from C. elegans

Ageing: Lessons from C. elegans
  • Author : Anders Olsen,Matthew S. Gill
  • Publisher : Springer
  • Release : 06 December 2016
GET THIS BOOKAgeing: Lessons from C. elegans

This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic