Genome Stability

"Genome Stability: From Virus to Human Application" covers the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, with the latter including major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, as well as changes in genome stability in response to aging. Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. This book teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. The book also covers how epigenetic factors contribute to genome stability and how species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effectsProvides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stabilityContains applications of genome instability and its effect on human diseasesExplains how various species maintain the fine balance in genome stability and genome diversification in response to their environments

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  • Author : Igor Kovalchuk
  • Publisher : Academic Press
  • Pages : 710 pages
  • ISBN : 9780128033098
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKGenome Stability

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk
  • Publisher : Academic Press
  • Release : 30 September 2016
GET THIS BOOKGenome Stability

"Genome Stability: From Virus to Human Application" covers the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, with the latter including major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, as well as changes in genome stability in response to aging. Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time,

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher : Academic Press
  • Release : 17 July 2021
GET THIS BOOKGenome Stability

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Pub
  • Release : 17 October 2021
GET THIS BOOKGenome Stability

"Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher : Academic Press
  • Release : 03 September 2016
GET THIS BOOKGenome Stability

Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments.

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher : Elsevier
  • Release : 05 August 2021
GET THIS BOOKGenome Stability

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA

Genome Stability

Genome Stability
  • Author : James Haber
  • Publisher : Garland Science
  • Release : 16 December 2013
GET THIS BOOKGenome Stability

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An

Genome Stability and Human Diseases

Genome Stability and Human Diseases
  • Author : Heinz-Peter Nasheuer
  • Publisher : Springer Science & Business Media
  • Release : 11 December 2009
GET THIS BOOKGenome Stability and Human Diseases

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our

Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer

Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer
  • Author : Tammy A. Morrish,Jose Luis García Pérez
  • Publisher : Frontiers Media SA
  • Release : 16 January 2018
GET THIS BOOKMobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer

The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (

The Genome Stability is Preserved by a Stress Response Protein: CCDC6

The Genome Stability is Preserved by a Stress Response Protein: CCDC6
  • Author : Chiara Luise,Angela Celetti
  • Publisher : LAP Lambert Academic Publishing
  • Release : 01 July 2012
GET THIS BOOKThe Genome Stability is Preserved by a Stress Response Protein: CCDC6

The maintenance of genomic stability is beneficial for the survival of an individual cell and crucial for cancer avoidance. Cells invest huge resources to maintain genomic stability, and cancer cells undergo an array of genetic changes to escape these barriers. The initiation of carcinogenesis represents a mutational event, which in most instances occurs despite functional DNA damage response (DDR) mechanisms. This dissertation aims to study the mechanisms of chromosomal instability in tumor development. We intend to investigate the role of

Maintaining Genome Stability: The Role of Helicases and Deaminases

Maintaining Genome Stability: The Role of Helicases and Deaminases
  • Author : Anonim
  • Publisher : Unknown Publisher
  • Release : 17 October 2021
GET THIS BOOKMaintaining Genome Stability: The Role of Helicases and Deaminases

Both helicases and deaminases are enzymes that play an important role in maintaining genomic stability and immune responses. Errors in duplicating DNA can result in genomic instability, leading to various human diseases, such as cancer, immune system disorder, muscle dystrophy, and neurodegenerations. Thus, maintaining genomic integrity is vital to the normal growth of cells and to human health. Maintenance of genome integrity during S phase depends in part on the activity and regulation of the replication enzymes, including replicative helicase

Genome Instability

Genome Instability
  • Author : Marco Muzi-Falconi,Grant W Brown
  • Publisher : Humana Press
  • Release : 20 October 2017
GET THIS BOOKGenome Instability

This volume presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and

Mapping and Sequencing the Human Genome

Mapping and Sequencing the Human Genome
  • Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
  • Publisher : National Academies Press
  • Release : 01 January 1988
GET THIS BOOKMapping and Sequencing the Human Genome

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a

Genome Instability and Transgenerational Effects

Genome Instability and Transgenerational Effects
  • Author : Igor Kovalchuk,Olga Kovalchuk (MD.)
  • Publisher : Nova Science Pub Incorporated
  • Release : 17 October 2021
GET THIS BOOKGenome Instability and Transgenerational Effects

Genome stability of every species depends on complex interaction of predefined and environmentally induced genetic and epigenetic states. Predefined states consist of chromatin structure and cell metabolic processes such as DNA repair, radical scavenging and cell signalling, whereas induced states depend on interactions with the environment. Organisms are able to respond to a changing environment by various alterations in their somatic cells as well as in their germline and progeny. In this book, we will describe various phenomena associated with