Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research

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  • Author : G V Sherbet
  • Publisher : Elsevier
  • Pages : 368 pages
  • ISBN : 0123878209
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKGrowth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy
  • Author : G V Sherbet
  • Publisher : Elsevier
  • Release : 12 July 2011
GET THIS BOOKGrowth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into

Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy
  • Author : Gajanan V. Sherbet
  • Publisher : Unknown Publisher
  • Release : 28 July 2011
GET THIS BOOKGrowth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into

Signal Transduction in Cancer

Signal Transduction in Cancer
  • Author : David A. Frank
  • Publisher : Springer Science & Business Media
  • Release : 18 April 2006
GET THIS BOOKSignal Transduction in Cancer

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and

Growth Factors and their Receptors in Cancer Metastasis

Growth Factors and their Receptors in Cancer Metastasis
  • Author : Wen G. Jiang,K. Matsumoto,T. Nakamura
  • Publisher : Springer Science & Business Media
  • Release : 11 April 2006
GET THIS BOOKGrowth Factors and their Receptors in Cancer Metastasis

about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our

Holland-Frei Cancer Medicine

Holland-Frei Cancer Medicine
  • Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
  • Publisher : John Wiley & Sons
  • Release : 10 March 2017
GET THIS BOOKHolland-Frei Cancer Medicine

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage

Therapeutic Strategies in Cancer Biology and Pathology

Therapeutic Strategies in Cancer Biology and Pathology
  • Author : Gajanan V. Sherbet
  • Publisher : Elsevier
  • Release : 26 July 2013
GET THIS BOOKTherapeutic Strategies in Cancer Biology and Pathology

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and

Molecular Approach to Cancer Management

Molecular Approach to Cancer Management
  • Author : Gajanan V. Sherbet
  • Publisher : Academic Press
  • Release : 15 June 2017
GET THIS BOOKMolecular Approach to Cancer Management

Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation

Genetic Recombination in Cancer

Genetic Recombination in Cancer
  • Author : Gajanan V. Sherbet
  • Publisher : Elsevier
  • Release : 24 July 2003
GET THIS BOOKGenetic Recombination in Cancer

Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed

The Genetics of Cancer

The Genetics of Cancer
  • Author : Gajanan V. Sherbet,M. S. Lakshmi
  • Publisher : Academic Press
  • Release : 22 June 1997
GET THIS BOOKThe Genetics of Cancer

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields

Fibroblast Growth Factors: Biology And Clinical Application - Fgf Biology And Therapeutics

Fibroblast Growth Factors: Biology And Clinical Application - Fgf Biology And Therapeutics
  • Author : Simons Michael
  • Publisher : World Scientific
  • Release : 27 December 2016
GET THIS BOOKFibroblast Growth Factors: Biology And Clinical Application - Fgf Biology And Therapeutics

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a

Growth Factors and Oncogenes

Growth Factors and Oncogenes
  • Author : M. Bolla,E. M. Chambaz,C. Vrousos
  • Publisher : Unknown Publisher
  • Release : 25 October 1989
GET THIS BOOKGrowth Factors and Oncogenes

The major objective of this book is to bring together specialists well-known for their contribution to the basic knowledge of growth factors and oncogenes and experts engaged in clinical research and prospective in cancer therapy."

The Effects of Insulin-Like Growth Factors on Human G292 Osteosarcoma Cells

The Effects of Insulin-Like Growth Factors on Human G292 Osteosarcoma Cells
  • Author : Thabet AlHousami
  • Publisher : Unknown Publisher
  • Release : 25 October 2021
GET THIS BOOKThe Effects of Insulin-Like Growth Factors on Human G292 Osteosarcoma Cells

Introduction: Osteosarcoma is the most common bone sarcoma in children and adolescents. It is an aggressive primary bone cancer recognized by abnormal cell proliferation and function. The insulin-like growth factor (IGF) system plays an integral role in the growth, differentiation, and developmental processes, and is involved in various physiological and pathological events. The IGF system consists of IGF I and II, their cell surface receptors and insulin-like growth factor binding proteins (IGFBP). IGF-binding proteins (IGFBPs) are important modulators of IGF

Insulin-Like Growth Factors

Insulin-Like Growth Factors
  • Author : Douglas Yee
  • Publisher : IOS Press
  • Release : 25 October 2021
GET THIS BOOKInsulin-Like Growth Factors

Over the past five years there has been an explosion of "targeted therapies" for cancer treatment. In most cases, these therapies have been based on pre-clinical data showing that specific molecules play an important role in regulating the malignant phenotype. In breast cancer, there is compelling rationale that such targeted strategies should be successful. Targeting of estrogen receptor ? (ER?) has proven to be a successful way to reduce breast cancer risk, decrease the risk of death and recurrence in an

Hormones and Cancer

Hormones and Cancer
  • Author : Wayne V. Vedeckis
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKHormones and Cancer

The series, Hormones in Health and Disease, was launched in 1993 to provide a scientific platform for investigators engaged in research on the biological actions of hormones and to anticipate relevance for their findings in clinical applications. The first volume of the series was dedicated to the discussion and understanding of molecular mechanisms by which steroid hormones influence target cells in normal and pathological conditions. With the diversity of information and the vast amount of literature on steroid hormone physiology, a

Blood Cell Biochemistry

Blood Cell Biochemistry
  • Author : Anthony D. Whetton,John Gordon
  • Publisher : Springer
  • Release : 31 August 1996
GET THIS BOOKBlood Cell Biochemistry

Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has