HPLC Method Development for Pharmaceuticals

High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge. Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities) Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase

Produk Detail:

  • Author : Satinder Ahuja
  • Publisher : Elsevier
  • Pages : 532 pages
  • ISBN : 0080554199
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKHPLC Method Development for Pharmaceuticals

HPLC Method Development for Pharmaceuticals

HPLC Method Development for Pharmaceuticals
  • Author : Satinder Ahuja,Henrik Rasmussen
  • Publisher : Elsevier
  • Release : 21 September 2011
GET THIS BOOKHPLC Method Development for Pharmaceuticals

High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes

An Introduction to HPLC for Pharmaceutical Analysis

An Introduction to HPLC for Pharmaceutical Analysis
  • Author : Oona McPolin
  • Publisher : Lulu.com
  • Release : 01 March 2009
GET THIS BOOKAn Introduction to HPLC for Pharmaceutical Analysis

If you are new to HPLC, this book provides an invaluable guide to how HPLC is actually used when analysing pharmaceuticals. It is full of practical advice on the operation of HPLC systems combined with the necessary theoretical knowledge to ensure understanding of the technique. Key features include: A thorough discussion of the stationary phase enabling the reader to make sense of the many parameters used to describe a HPLC column; Practical advice and helpful hints for the preparation and

Handbook of Pharmaceutical Analysis by HPLC

Handbook of Pharmaceutical Analysis by HPLC
  • Author : Satinder Ahuja,Michael Dong
  • Publisher : Elsevier
  • Release : 09 February 2005
GET THIS BOOKHandbook of Pharmaceutical Analysis by HPLC

High pressure liquid chromatography–frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected experts in their respective fields, the Handbook of Pharmaceutical Analysis by HPLC Volume 6, provides a complete yet concise reference guide for utilizing the versatility of HPLC in drug development and quality control. Highlighting novel approaches in HPLC and the latest developments in hyphenated techniques, the book captures the

Analytical Method Development and Validation

Analytical Method Development and Validation
  • Author : Michael E. Swartz,Ira S. Krull
  • Publisher : CRC Press
  • Release : 16 May 1997
GET THIS BOOKAnalytical Method Development and Validation

Describes analytical methods development, optimization and validation, and provides examples of successful methods development and validation in high-performance liquid chromatography (HPLC) areas. The text presents an overview of Food and Drug Administration (FDA)/International Conference on Harmonization (ICH) regulatory guidelines, compliance with validation requirements for regulatory agencies, and methods validation criteria stipulated by the US Pharmacopia, FDA and ICH.

HPLC Methods for Recently Approved Pharmaceuticals

HPLC Methods for Recently Approved Pharmaceuticals
  • Author : George Lunn
  • Publisher : John Wiley & Sons
  • Release : 06 May 2005
GET THIS BOOKHPLC Methods for Recently Approved Pharmaceuticals

An indispensable resource for busy researchers Your time is valuable-too valuable to spend hunting through thetechnical literature in search of the right HPLC assay techniquesfor your projects. With HPLC Methods for Recently ApprovedPharmaceuticals, you'll quickly identify and replicate the idealprocedures for your project needs, without having to refer tooriginal source publications. More of your time can then be spentin the lab, not the library. Covering the relevant world literature through 2003, this bookpicks up where Dr. Lunn's acclaimed HPLC Methods for

HPLC for Pharmaceutical Scientists

HPLC for Pharmaceutical Scientists
  • Author : Yuri V. Kazakevich,Rosario LoBrutto
  • Publisher : John Wiley & Sons
  • Release : 16 February 2007
GET THIS BOOKHPLC for Pharmaceutical Scientists

HPLC for Pharmaceutical Scientists is an excellent book for both novice and experienced pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and

Biochemical Analysis Tools

Biochemical Analysis Tools
  • Author : Oana-Maria Boldura,Cornel Balta,Prof Nasser Awwad
  • Publisher : BoD – Books on Demand
  • Release : 24 June 2020
GET THIS BOOKBiochemical Analysis Tools

This book explores the role of nucleic acid analysis and the advances it has led to in the field of life sciences. The first section is a collection of chapters covering experimental methods used in molecular biology, the techniques adjacent to these methods, and the steps of analysis before and after obtaining raw DNA data. The second section deals with the principles of chromatography, method development, sample preparation, and industrial applications.

Development of Novel Stability Indicating Methods Using Liquid Chromatography

Development of Novel Stability Indicating Methods Using Liquid Chromatography
  • Author : Mukesh Maithani,Parveen Bansal
  • Publisher : Springer
  • Release : 07 August 2019
GET THIS BOOKDevelopment of Novel Stability Indicating Methods Using Liquid Chromatography

Reversed-phase high-performance liquid chromatography (RP-HPLC) has become the most widely used method for pharmaceutical analysis, as it ensures accuracy, specificity and reproducibility for the quantification of drugs, while avoiding interference from any of the excipients that are normally present in pharmaceutical dosage forms. This book presents a simple methodology for developing stability-indicating methods and offers a ‘how-to guide’ to creating novel stability-indicating methods using liquid chromatography. It provides the detailed information needed to devise a stability-indicating method for drug substances

Handbook of Analytical Validation

Handbook of Analytical Validation
  • Author : Michael E. Swartz,Ira S. Krull
  • Publisher : CRC Press
  • Release : 24 April 2012
GET THIS BOOKHandbook of Analytical Validation

Written for practitioners in both the drug and biotechnology industries, the Handbook of Analytical Validation carefully compiles current regulatory requirements on the validation of new or modified analytical methods. Shedding light on method validation from a practical standpoint, the handbook:Contains practical, up-to-date guidelines for analyti

Modern HPLC for Practicing Scientists

Modern HPLC for Practicing Scientists
  • Author : Michael W. Dong
  • Publisher : John Wiley & Sons
  • Release : 06 April 2016
GET THIS BOOKModern HPLC for Practicing Scientists

A comprehesive yet concise guide to Modern HPLC Written for practitioners by a practitioner, Modern HPLC for Practicing Scientists is a concise text which presents the most important High-Performance Liquid Chromatography (HPLC) fundamentals, applications, and developments. It describes basic theory and terminology for the novice, and reviews relevant concepts, best practices, and modern trends for the experienced practitioner. Moreover, the book serves well as an updated reference guide for busy laboratory analysts and researchers. Topics covered include: HPLC operation Method

Practical HPLC Method Development

Practical HPLC Method Development
  • Author : Lloyd R. Snyder,Joseph J. Kirkland,Joseph L. Glajch
  • Publisher : John Wiley & Sons
  • Release : 03 December 2012
GET THIS BOOKPractical HPLC Method Development

This revision brings the reader completely up to date on the evolving methods associated with increasingly more complex sample types analyzed using high-performance liquid chromatography, or HPLC. The book also incorporates updated discussions of many of the fundamental components of HPLC systems and practical issues associated with the use of this analytical method. This edition includes new or expanded treatments of sample preparation, computer assisted method development, as well as biochemical samples, and chiral separations.

Capillary Electrophoresis Methods for Pharmaceutical Analysis

Capillary Electrophoresis Methods for Pharmaceutical Analysis
  • Author : Satinder Ahuja,Mohamedilias Jimidar
  • Publisher : Elsevier
  • Release : 09 August 2011
GET THIS BOOKCapillary Electrophoresis Methods for Pharmaceutical Analysis

Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC.

Software-assisted Method Development In High Performance Liquid Chromatography

Software-assisted Method Development In High Performance Liquid Chromatography
  • Author : Szabolcs Fekete,Imre Molnar
  • Publisher : World Scientific
  • Release : 01 August 2018
GET THIS BOOKSoftware-assisted Method Development In High Performance Liquid Chromatography

'The book is a useful contribution in the field of HPLC, and may represent a valuable tool for chromatography practitioners in different fields, as well as teachers and instructors. The 12 chapters provide comprehensive insights of current day retention and resolution modelling in HPLC, and its applications for small and large molecule analysis. It may be a useful reference for specialists in pharmaceuticals but not limited to … It may be a valuable resource to assist scientists involved in method development, aiming

Calibration and Validation of Analytical Methods

Calibration and Validation of Analytical Methods
  • Author : Mark Stauffer
  • Publisher : BoD – Books on Demand
  • Release : 25 April 2018
GET THIS BOOKCalibration and Validation of Analytical Methods

This book seeks to introduce the reader to current methodologies in analytical calibration and validation. This collection of contributed research articles and reviews addresses current developments in the calibration of analytical methods and techniques and their subsequent validation. Section 1, "Introduction," contains the Introductory Chapter, a broad overview of analytical calibration and validation, and a brief synopsis of the following chapters. Section 2 "Calibration Approaches" presents five chapters covering calibration schemes for some modern analytical methods and techniques. The last chapter in