Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia

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  • Author : Shuguang Ma
  • Publisher : Elsevier
  • Pages : 708 pages
  • ISBN : 0128200197
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKIdentification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters
  • Author : Shuguang Ma,Swapan Chowdhury
  • Publisher : Elsevier
  • Release : 09 July 2020
GET THIS BOOKIdentification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small

Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS

Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS
  • Author : Swapan Chowdhury
  • Publisher : Elsevier
  • Release : 04 November 2005
GET THIS BOOKIdentification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS

As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity
  • Author : Albert P. Li
  • Publisher : John Wiley & Sons
  • Release : 29 June 2021
GET THIS BOOKTransporters and Drug-Metabolizing Enzymes in Drug Toxicity

This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity – two aspects not normally connected and the latter often neglected Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transporters Discusses promising approaches to accurately predict human drug toxicity via the incorporation of human drug

Mass Spectrometry in Drug Metabolism and Disposition

Mass Spectrometry in Drug Metabolism and Disposition
  • Author : Mike S. Lee,Mingshe Zhu
  • Publisher : John Wiley & Sons
  • Release : 16 March 2011
GET THIS BOOKMass Spectrometry in Drug Metabolism and Disposition

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets

Drug Metabolism in Drug Design and Development

Drug Metabolism in Drug Design and Development
  • Author : Donglu Zhang,Mingshe Zhu,William G. Humphreys
  • Publisher : John Wiley & Sons
  • Release : 16 November 2007
GET THIS BOOKDrug Metabolism in Drug Design and Development

The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed

Biodegradation and Biodeterioration at the Nanoscale

Biodegradation and Biodeterioration at the Nanoscale
  • Author : Hafiz M.N. Iqbal,Muhammad Bilal,Tuan Anh Nguyen,Ghulam Yasin
  • Publisher : Elsevier
  • Release : 08 October 2021
GET THIS BOOKBiodegradation and Biodeterioration at the Nanoscale

Biodegradation and Biodeterioration at the Nanoscale describes the biodegradation and biodeterioration of materials in the presence of nanomaterials. The book's chapters focus on the basic principles, action mechanisms and promising applications of advanced nanomaterials, along with their integration with biotechnological processes for controlled degradation and deterioration of materials. In addition, the current research indications, positive or negative environmental impacts, legislation and future directions are also discussed. This book is an important reference source for researchers, engineers and scientists working in

Recent Advances in Analytical Techniques: Volume 5

Recent Advances in Analytical Techniques: Volume 5
  • Author : Atta-ur-Rahman,Sibel Ozkan
  • Publisher : Bentham Science Publishers
  • Release : 05 January 2022
GET THIS BOOKRecent Advances in Analytical Techniques: Volume 5

Recent Advances in Analytical Techniques is a series of updates in techniques used in chemical analysis. Each volume presents a selection of chapters that explain different analytical techniques and their use in applied research. Readers will find updated information about developments in analytical methods such as chromatography, electrochemistry, optical sensor arrays for pharmaceutical and biomedical analysis. The fifth volume of the series features five reviews which demonstrate chemical analysis techniques applied in different disciplines. - Superior Aspects of Liquid Chromatography-Based

Drug Transporters

Drug Transporters
  • Author : Martin F. Fromm,Richard B. Kim
  • Publisher : Springer Science & Business Media
  • Release : 19 November 2010
GET THIS BOOKDrug Transporters

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Topics on Drug Metabolism

Topics on Drug Metabolism
  • Author : James Paxton
  • Publisher : BoD – Books on Demand
  • Release : 22 February 2012
GET THIS BOOKTopics on Drug Metabolism

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and

Biotransformation and Metabolite Elucidation of Xenobiotics

Biotransformation and Metabolite Elucidation of Xenobiotics
  • Author : Ala F. Nassar
  • Publisher : John Wiley & Sons
  • Release : 23 March 2011
GET THIS BOOKBiotransformation and Metabolite Elucidation of Xenobiotics

The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity. The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity
  • Author : Albert P. Li
  • Publisher : John Wiley & Sons
  • Release : 27 July 2021
GET THIS BOOKTransporters and Drug-Metabolizing Enzymes in Drug Toxicity

This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity – two aspects not normally connected and the latter often neglected Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transporters Discusses promising approaches to accurately predict human drug toxicity via the incorporation of human drug

Reactive Drug Metabolites

Reactive Drug Metabolites
  • Author : Amit S. Kalgutkar,Deepak Dalvie,R. Scott Obach,Dennis A. Smith
  • Publisher : John Wiley & Sons
  • Release : 06 September 2012
GET THIS BOOKReactive Drug Metabolites

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation,

Enzyme Kinetics in Drug Metabolism

Enzyme Kinetics in Drug Metabolism
  • Author : Swati Nagar,Upendra Argikar,Donald Tweedie
  • Publisher : Humana Press
  • Release : 13 February 2014
GET THIS BOOKEnzyme Kinetics in Drug Metabolism

Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches

Drug Metabolism, Pharmacokinetics and Bioanalysis

Drug Metabolism, Pharmacokinetics and Bioanalysis
  • Author : Hye Suk Lee,Kwang-Hyeon Liu
  • Publisher : MDPI
  • Release : 12 June 2019
GET THIS BOOKDrug Metabolism, Pharmacokinetics and Bioanalysis

Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There

Textbook of Personalized Medicine

Textbook of Personalized Medicine
  • Author : Kewal K. Jain
  • Publisher : Humana Press
  • Release : 17 March 2015
GET THIS BOOKTextbook of Personalized Medicine

Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory