In Vivo Models to Study Angiogenesis

In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available. Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling. Provides information on the most common assays to study angiogenesis in vivo Presents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and development Covers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant

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  • Author : Domenico Ribatti
  • Publisher : Academic Press
  • Pages : 112 pages
  • ISBN : 0128140216
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKIn Vivo Models to Study Angiogenesis

In Vivo Models to Study Angiogenesis

In Vivo Models to Study Angiogenesis
  • Author : Domenico Ribatti
  • Publisher : Academic Press
  • Release : 18 August 2017
GET THIS BOOKIn Vivo Models to Study Angiogenesis

In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents

Angiogenesis Assays

Angiogenesis Assays
  • Author : Carolyn A. Staton,Claire Lewis,Roy Bicknell
  • Publisher : John Wiley & Sons
  • Release : 11 January 2007
GET THIS BOOKAngiogenesis Assays

Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo,

Tumor Microenvironment Regulation of Tumor Expansion

Tumor Microenvironment Regulation of Tumor Expansion
  • Author : Domenico Ribatti
  • Publisher : Academic Press
  • Release : 04 April 2021
GET THIS BOOKTumor Microenvironment Regulation of Tumor Expansion

Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs

Tumor Vascularization

Tumor Vascularization
  • Author : Domenico Ribatti,Francesco Pezzella
  • Publisher : Academic Press
  • Release : 07 January 2020
GET THIS BOOKTumor Vascularization

Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a

Angiogenesis in Health and Disease

Angiogenesis in Health and Disease
  • Author : Michael E. Maragoudakis,Pietro M. Gullino,Peter I. Lelkes
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKAngiogenesis in Health and Disease

Angiogenesis describes the formation of new blood vessels, which arise as outgrowths from existing vessels. In many physiological processes such as ovulation and wound healing angiogenesis is involved for a relatively short time. Otherwise under normal physiological conditions in the adult organism angiogenesis is an extremely slow process. By contrast in certain disease states such as diabetic retinopathy, arthritis, chronic inflammation, hemangiomas, etc., angiogenesis persists and contributes to the pathology of these disease states. Some 50 such "angiogenic diseases" have been

Inhibitors of corneal inflammation and angiogenesis

Inhibitors of corneal inflammation and angiogenesis
  • Author : Pierfrancesco Mirabelli
  • Publisher : Linköping University Electronic Press
  • Release : 30 April 2019
GET THIS BOOKInhibitors of corneal inflammation and angiogenesis

Pathologic angiogenesis is involved in cancer and several blinding conditions such as wet age-related macular degeneration, proliferative retinopathies and corneal neovascularization. In these dieseases, the angiogenic triggers are hypoxia and inflammation, and both involve the main angiogenic mediator, which is Vascular Endothelial Growth Factor (VEGF). Among available treatments, anti-VEGF often shows limited or temporary efficacy, while steroids are potentially responsible for many side-effects. This thesis presents a series of linked studies aimed at elucidating the early pathologic changes leading to

Physiologic and Pathologic Angiogenesis

Physiologic and Pathologic Angiogenesis
  • Author : Dan Simionescu,Agneta Simionescu
  • Publisher : BoD – Books on Demand
  • Release : 05 April 2017
GET THIS BOOKPhysiologic and Pathologic Angiogenesis

The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that

In Vivo Models of Inflammation

In Vivo Models of Inflammation
  • Author : Lisa A. Marshall,Douglas W. Morgan
  • Publisher : Birkhäuser
  • Release : 11 November 2013
GET THIS BOOKIn Vivo Models of Inflammation

The purpose of this volume in the series Progress in Inflammation Research is to pro vide the biomedical researcher with a description of the state of the art of the devel opment and use of animal models of diseases with components of inflammation. Par ticularly highlighted are those models which can serve as in vivo correlates of diseases most commonly targeted for therapeutic intervention. The format is designed with the laboratory in mind; thus it provides detailed descriptions of the

Investigating mechanisms of angiogenesis in health and disease using zebrafish models

Investigating mechanisms of angiogenesis in health and disease using zebrafish models
  • Author : Zaheer Ali
  • Publisher : Linköping University Electronic Press
  • Release : 07 December 2018
GET THIS BOOKInvestigating mechanisms of angiogenesis in health and disease using zebrafish models

Angiogenesis, the growth of blood vessels from an existing vasculature, can occur by sprouting from preexisting vessels or by vessel splitting (intussusception). Pathological angiogenesis drives choroidal neovascularization (CNV) in age related macular degeneration (AMD) which is commonly restricted under the retinal pigment epithelium (RPE), called occult CNV, but may also involve vessels penetrating through the RPE into the sub-retinal space. Pathological vessels are poorly developed, insufficiently perfused and highly leaky, phenotypes that are considered to drive disease progression and lead

Clinically Applied Microcirculation Research

Clinically Applied Microcirculation Research
  • Author : John H. Barker,Gary L. Anderson,Michael D. Menger
  • Publisher : Routledge
  • Release : 04 June 2019
GET THIS BOOKClinically Applied Microcirculation Research

First published in 1995: Clinically Applied Microcirculation Research combines state-of-the-art microcirculation technology with present and potential applications in clinical medicine. This comprehensive guide unites the expertise of clinicians and basic researchers from around the world. Many of the chapters are authored by scientist/physician teams. The book provides a broad overview of how microcirculation is involved in clinical research. This is also a valuable reference source for both the history of and latest developments in microcirculation research.

Mouse as a Model Organism

Mouse as a Model Organism
  • Author : Cord Brakebusch,Taina Pihlajaniemi
  • Publisher : Springer Science & Business Media
  • Release : 29 March 2011
GET THIS BOOKMouse as a Model Organism

Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or

Tumour Angiogenesis

Tumour Angiogenesis
  • Author : R. John Bicknell,Claire E. Lewis,Napoleone Ferrara
  • Publisher : Oxford University Press, USA
  • Release : 03 December 1997
GET THIS BOOKTumour Angiogenesis

It is now widely recognised that the growth of solid tumours is angiogenesis dependent. The inhibition of tumour angiogenesis offers a novel anti-cancer therapeutic strategy. In this first book to be devoted solely to tumour angiogenesis each chapter is written by leading world experts and the twenty seven chapters taken together cover all aspects of the field.

Immunology in the Twentieth Century

Immunology in the Twentieth Century
  • Author : Domenico Ribatti
  • Publisher : Academic Press
  • Release : 24 April 2018
GET THIS BOOKImmunology in the Twentieth Century

Immunology in the Twentieth Century: From Basic Science to Clinical Application grew out of common knowledge that those who survived many of the common infectious diseases rarely contracted the same disease again. This book charts the historical development of this vital branch of medicine in a concise volume, covering both the basic science involved and the clinical applications. Immunology as a distinctive subject developed in the mid-twentieth century as researchers started to understand how the adaptive immune system aids the

Milestones in Immunology

Milestones in Immunology
  • Author : Domenico Ribatti
  • Publisher : Academic Press
  • Release : 13 June 2017
GET THIS BOOKMilestones in Immunology

Milestones in Immunology: Based on Collected Papers contains scientific milestones relating to the history of medicine over the past two centuries. The book highlights the contributions of pioneering scientists whose discoveries have paved the way for researchers working in the field of immunology. As the science of immunology grew from knowledge that survivors of common infectious diseases rarely contracted them again, the book uses this as a central thesis, helping readers understand how the adaptive immune system aids in defense

Angiogenesis in Brain Tumors

Angiogenesis in Brain Tumors
  • Author : Matthias Kirsch,Peter McL. Black
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKAngiogenesis in Brain Tumors

- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field