Intracellular Consequences of Amyloid in Alzheimer s Disease

Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death. Presents the latest research on the significance of intracellular amyloid as it relates to Alzheimer’s Addresses crucial questions about intracellular amyloid, including how if forms and enters neurons, its toxicity, if it triggers cell death, and how amyloid plaques are formed Examines the potential relationship between intracellular amyloid, plaques, and cognitive impairment in an effort to answer whether Alzheimer’s is initially a problem of amyloid, the neuron, or of the blood-brain barrier Seeks to help researchers generate additional alternative therapeutic opportunities to cure Alzheimer’s

Produk Detail:

  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Pages : 220 pages
  • ISBN : 012804330X
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKIntracellular Consequences of Amyloid in Alzheimer s Disease

Intracellular Consequences of Amyloid in Alzheimer's Disease

Intracellular Consequences of Amyloid in Alzheimer's Disease
  • Author : Michael R. D'Andrea
  • Publisher : Academic Press
  • Release : 21 February 2016
GET THIS BOOKIntracellular Consequences of Amyloid in Alzheimer's Disease

Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid

Update on Dementia

Update on Dementia
  • Author : Davide Moretti
  • Publisher : BoD – Books on Demand
  • Release : 28 September 2016
GET THIS BOOKUpdate on Dementia

The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
  • Author : Adeboye Adejare
  • Publisher : Academic Press
  • Release : 20 September 2016
GET THIS BOOKDrug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies,

Developing Therapeutics for Alzheimer's Disease

Developing Therapeutics for Alzheimer's Disease
  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release : 27 May 2016
GET THIS BOOKDeveloping Therapeutics for Alzheimer's Disease

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the

Advances in Alzheimer's Research

Advances in Alzheimer's Research
  • Author : Debomoy K. Lahiri
  • Publisher : Bentham Science Publishers
  • Release : 05 November 2013
GET THIS BOOKAdvances in Alzheimer's Research

Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is globally afflicting an estimated 36 million people and this number is growing in an unabated and frightening manner. Advances in Alzheimer Research, provides researchers with an integrated approach to AD academic literature ranging from basic to advanced clinical research. The series highlights the latest information in order to unravel the origin, pathogenesis and prevention of AD. The purpose of this book series is, therefore,

Recent Progress in Alzheimer's and Parkinson's Diseases

Recent Progress in Alzheimer's and Parkinson's Diseases
  • Author : Israel Hanin,Ramon Cacabelos,Abraham Fisher
  • Publisher : CRC Press
  • Release : 03 June 2005
GET THIS BOOKRecent Progress in Alzheimer's and Parkinson's Diseases

This book brings together the proceedings of Alzheimer's and Parkinson's Diseases: New Perspectives, the Sixth International Conference on Alzheimer's Disease and Parkinson's Disease, held recently in Seville, Spain, and discusses the latest developments in the basic science and therapy of Alzheimer's and Parkinson's diseases by leading specialists

The Neuron-inflammatory Effects of Intracellular A[beta]

The Neuron-inflammatory Effects of Intracellular A[beta]
  • Author : Lindsay Welikovitch
  • Publisher : Unknown Publisher
  • Release : 24 May 2022
GET THIS BOOKThe Neuron-inflammatory Effects of Intracellular A[beta]

"AbstractDespite being the most common cause of dementia worldwide, there are still no available drugs to prevent or cure Alzheimer’s disease (AD). In addition to the deposition of amyloid-[beta] (A[beta]) plaques and tau neurofibrillary tangles (NFT) as hallmark brain lesions, the AD neuropathology comprises a significant immunological component. That inflammation is likely a contributory factor in the AD pathogenesis is evidenced by the fact that chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) in cognitively healthy adults protects

Alzheimer's Disease

Alzheimer's Disease
  • Author : George Perry
  • Publisher : IOS Press
  • Release : 24 May 2022
GET THIS BOOKAlzheimer's Disease

This volume is a companion to the highly successful book published in association with the Journal of Alzheimers Disease JAD on the centennial of Alzheimers discovery Alzheimers Disease A Century of Scientific and Clinical Research. Instead of looking back, this collection, Alzheimers Disease Advances for a New Century, will look forward. Using scientometric analysis the most promising developments since the Alzheimer Centennial in 2006 have been substantiated. While prior trends and advances in genetics, amyloid-, tau, neuropathology, and oxidative stress continue

Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor

Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor
  • Author : Enikö Kallay
  • Publisher : Frontiers Media SA
  • Release : 09 July 2018
GET THIS BOOKPhysiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor

Calcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing receptor (CaSR). The CaSR is a multifaceted molecule that senses changes in the concentration of a wide variety of environmental factors including di- and trivalent cations, amino acids, polyamines, and pH. In calcitropic tissues with obvious roles in

The Biology of Alzheimer Disease

The Biology of Alzheimer Disease
  • Author : Dennis J. Selkoe,David Michael Holtzman,Eckhard Mandelkow
  • Publisher : Unknown Publisher
  • Release : 24 May 2022
GET THIS BOOKThe Biology of Alzheimer Disease

Alzheimer Disease represents an important area of research in neurobiology, cell biology, developmental biology and pathology. Understanding the nature of the changes that occur in neurons as the disease progresses — accumulation of amyloid beta and neurofibrillary tangles — is obviously important as we try to develop therapeutic approaches. Moreover, the normal physiological roles of proteins such as APP and tau, whose processing appears to be altered in Alzheimer Disease, is also an intense area of research.

Handbook of Models for Human Aging

Handbook of Models for Human Aging
  • Author : P. Michael Conn
  • Publisher : Elsevier
  • Release : 28 April 2011
GET THIS BOOKHandbook of Models for Human Aging

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion

Amyloid-beta clearance in Alzheimer’s disease

Amyloid-beta clearance in Alzheimer’s disease
  • Author : Robert Marr,Eliezer Masliah
  • Publisher : Frontiers Media SA
  • Release : 24 March 2015
GET THIS BOOKAmyloid-beta clearance in Alzheimer’s disease

Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers