Key Heterocycle Cores for Designing Multitargeting Molecules

Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research. Emphasizes the chemical development of heterocyclic nuclei, from single to multitargeting molecules Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multitargeting agents Outlines current trends and future developments in multitarget molecule design for the treatment of various diseases

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  • Author : Om Silakari
  • Publisher : Elsevier
  • Pages : 436 pages
  • ISBN : 0081021054
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKKey Heterocycle Cores for Designing Multitargeting Molecules

Key Heterocycle Cores for Designing Multitargeting Molecules

Key Heterocycle Cores for Designing Multitargeting Molecules
  • Author : Om Silakari
  • Publisher : Elsevier
  • Release : 11 June 2018
GET THIS BOOKKey Heterocycle Cores for Designing Multitargeting Molecules

Key Heterocycle Cores for Designing Multitargeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multitargeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry
  • Author : Eric Scriven,Christopher A. Ramsden
  • Publisher : Academic Press
  • Release : 01 May 2020
GET THIS BOOKAdvances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

Surfactants from Renewable Raw Materials

Surfactants from Renewable Raw Materials
  • Author : Divya Bajpai Tripathy,Anjali Gupta,Arvind Kumar Jain,Anuradha Mishra
  • Publisher : CRC Press
  • Release : 22 December 2021
GET THIS BOOKSurfactants from Renewable Raw Materials

Surfactants are often completely invisible to us and yet they are present in almost every chemical that we use in our daily life. They are found in toothpastes, cosmetics, sunscreens, mayonnaise, detergents, and an array of cleaning products. Traditional surfactants are known to have adverse environmental impacts spurring research into eco-friendly and cost-effective surfactants from renewable resources. Surfactants from Renewable Raw Materials examines the class of surfactants synthesized using plant-based raw materials detailing their properties, applications, bioavailability, and biodegradability. The

Privileged Scaffolds in Medicinal Chemistry

Privileged Scaffolds in Medicinal Chemistry
  • Author : Stefan Bräse
  • Publisher : Royal Society of Chemistry
  • Release : 20 November 2015
GET THIS BOOKPrivileged Scaffolds in Medicinal Chemistry

One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular fragments. The first of the benzodiazepines, a class of drugs that is powerful for treating anxiety, may not have been discovered had it not been for a chance experiment on the contents of

Organic Syntheses Based on Name Reactions and Unnamed Reactions

Organic Syntheses Based on Name Reactions and Unnamed Reactions
  • Author : Alfred Hassner,C Stumer
  • Publisher : Elsevier
  • Release : 22 October 2013
GET THIS BOOKOrganic Syntheses Based on Name Reactions and Unnamed Reactions

Synthetically useful organic reactions or reagents are often referred to by the name of the discoverer(s) or developer(s). Older name reactions are described in text books, but more recently developed synthetically useful reactions that may have been associated occasionally with a name are not always well known. For neither of the above are experimental procedures or references easy to find. In this monograph approximately 500 name reactions are included, of which over 200 represent newer name reactions and modern reagents.

Synthesis of Best-Seller Drugs

Synthesis of Best-Seller Drugs
  • Author : Ruben Vardanyan,Victor Hruby
  • Publisher : Academic Press
  • Release : 07 January 2016
GET THIS BOOKSynthesis of Best-Seller Drugs

Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work

Fragment-based Drug Discovery

Fragment-based Drug Discovery
  • Author : Daniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release : 23 February 2016
GET THIS BOOKFragment-based Drug Discovery

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery
  • Author : Jie Jack Li
  • Publisher : John Wiley & Sons
  • Release : 26 April 2013
GET THIS BOOKHeterocyclic Chemistry in Drug Discovery

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own

The Chemistry of Heterocycles

The Chemistry of Heterocycles
  • Author : Vishnu Ji Ram,Arun Sethi,Mahendra Nath,Ramendra Pratap
  • Publisher : Elsevier
  • Release : 05 June 2019
GET THIS BOOKThe Chemistry of Heterocycles

Heterocycles are ubiquitously present in nature and occupy a unique place in organic chemistry as they are part of the DNA and haemoglobin that make life possible. The Chemistry of Heterocycles covers an introduction to the topic, followed by a chapter on the nomenclature of all classes of isolated, fused and polycyclic heterocycles. The third chapter delineates the highly strained three membered N,O and S containing aromatic and non-aromatic heterocycles with one and more than one similar and dissimilar

Heterocyclic N-Oxides

Heterocyclic N-Oxides
  • Author : Oleg V. Larionov
  • Publisher : Springer
  • Release : 12 July 2017
GET THIS BOOKHeterocyclic N-Oxides

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In

Handbook of Heterocyclic Chemistry

Handbook of Heterocyclic Chemistry
  • Author : Alan R. Katritzky
  • Publisher : Elsevier
  • Release : 31 January 2017
GET THIS BOOKHandbook of Heterocyclic Chemistry

Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of

Small Molecule Medicinal Chemistry

Small Molecule Medicinal Chemistry
  • Author : Werngard Czechtizky,Peter Hamley
  • Publisher : John Wiley & Sons
  • Release : 21 September 2015
GET THIS BOOKSmall Molecule Medicinal Chemistry

Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing,

Recent Advances in Applications of Name Reactions in Multicomponent Reactions

Recent Advances in Applications of Name Reactions in Multicomponent Reactions
  • Author : Majid M. Heravi,Vahideh Zadsirjan
  • Publisher : Elsevier
  • Release : 29 May 2020
GET THIS BOOKRecent Advances in Applications of Name Reactions in Multicomponent Reactions

Recent Advances in Applications of Name Reactions in Multicomponent Reactions is an ideal reference for researchers and postgraduate students studying organic chemistry, as well as synthetic organic chemists working on the development of novel methodologies for the synthesis of various heterocyclic systems, especially drug design and discovery, in both academia and industry. The book reviews recent applications of name reactions in multicomponents for the synthesis of heterocycles and examines recent advances in applications of significant name reactions, such as Ugi

Drug-like Properties: Concepts, Structure Design and Methods

Drug-like Properties: Concepts, Structure Design and Methods
  • Author : Li Di,Edward H Kerns
  • Publisher : Elsevier
  • Release : 26 July 2010
GET THIS BOOKDrug-like Properties: Concepts, Structure Design and Methods

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design
  • Author : Bimal K. Banik
  • Publisher : Elsevier
  • Release : 27 March 2020
GET THIS BOOKGreen Approaches in Medicinal Chemistry for Sustainable Drug Design

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and