Late Stage Fluorination of Bioactive Molecules and Biologically Relevant Substrates

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work. Highlights the latest developments in the field in a concise volume Provides details of key fluorinating reagents across diverse families of organic compounds Explores the current applications and future potential of fluorine in drug development

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  • Author : Al Postigo
  • Publisher : Elsevier
  • Pages : 390 pages
  • ISBN : 0128130393
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKLate Stage Fluorination of Bioactive Molecules and Biologically Relevant Substrates

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates
  • Author : Al Postigo
  • Publisher : Elsevier
  • Release : 05 September 2018
GET THIS BOOKLate-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates

Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad

Nontraditional Activation Methods in Green and Sustainable Applications

Nontraditional Activation Methods in Green and Sustainable Applications
  • Author : Bela Torok,Christian Schaefer
  • Publisher : Elsevier
  • Release : 28 February 2021
GET THIS BOOKNontraditional Activation Methods in Green and Sustainable Applications

Nontraditional Activation Methods in Green and Sustainable Applications: Microwaves; Ultrasounds; Photo-, Electro- and Mechan-ochemistry and High Hydrostatic Pressure provides a broad overview of non-traditional activation methods to help readers identify and use appropriate approaches in reducing the environmental impact of their work. Sections discuss the fundamental principles of each method and provide examples of their practical use, illustrating their usefulness. Given the importance of expanding laboratory based technologies to the industrial level, chapters that cover both existing and potential industrial

Organofluorine Chemistry

Organofluorine Chemistry
  • Author : Kalman J. Szabo,Nicklas Selander
  • Publisher : John Wiley & Sons
  • Release : 05 January 2021
GET THIS BOOKOrganofluorine Chemistry

By presenting novel methods for the efficient preparation of fluorinated compounds and their application in pharmaceutical and agrochemical chemistry as well as medicine, this is a valuable source of information for all researchers in academia and industry!

Fluorination

Fluorination
  • Author : Jinbo Hu,Teruo Umemoto
  • Publisher : Springer
  • Release : 12 August 2020
GET THIS BOOKFluorination

This volume reviews the recent advances in formation of C-F bonds and X-F bonds (X = heteroatom) to produce useful fluorinated molecules for pharmaceuticals, materials and more. Reactions and methods associated with fluorination, including monofluorination, difluorination, trifluorination and other polyfluorination that have emerged within the past few years are systematically discussed. With contributions from front-line researchers in this field from both academia and industry, this book provides a valuable resource for scholars, graduate students as well as professionals.

Organofluorine Compounds in Biology and Medicine

Organofluorine Compounds in Biology and Medicine
  • Author : V Prakash Reddy
  • Publisher : Newnes
  • Release : 25 January 2015
GET THIS BOOKOrganofluorine Compounds in Biology and Medicine

This book covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area. Covers the synthesis, biochemical, and therapeutic applications of organofluorine compounds Offers a complete text on biochemically relevant organofluorine compounds and their synthesis and mechanistic pathways Provides one of the first major reference books on the biological and medicinal

Modern Synthesis Processes and Reactivity of Fluorinated Compounds

Modern Synthesis Processes and Reactivity of Fluorinated Compounds
  • Author : Henri Groult,Frederic Leroux,Alain Tressaud
  • Publisher : Elsevier
  • Release : 04 November 2016
GET THIS BOOKModern Synthesis Processes and Reactivity of Fluorinated Compounds

Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with

Approaches to Design and Synthesis of Antiparasitic Drugs

Approaches to Design and Synthesis of Antiparasitic Drugs
  • Author : N. Anand,S. Sharma†
  • Publisher : Elsevier
  • Release : 10 July 1997
GET THIS BOOKApproaches to Design and Synthesis of Antiparasitic Drugs

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and

Biological Potential and Medical Use of Secondary Metabolites

Biological Potential and Medical Use of Secondary Metabolites
  • Author : Ana M. L Seca,Diana Cláudia Pinto
  • Publisher : MDPI
  • Release : 26 July 2019
GET THIS BOOKBiological Potential and Medical Use of Secondary Metabolites

Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites

Green Synthetic Approaches for Biologically Relevant Heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles
  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release : 17 November 2014
GET THIS BOOKGreen Synthetic Approaches for Biologically Relevant Heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles reviews this significant group of organic compounds within the context of sustainable methods and processes. Each clearly structured chapter features in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles classified on the basis of ring-size and/or presence of heteratoms(s). Techniques covered include microwave heating, ultrasound, ionic liquids, solid phase, solvent-free, heterogeneous catalysis, and aqueous media, along with multi-component reaction strategies. This book also integrates

Cannabinoids in Neurologic and Mental Disease

Cannabinoids in Neurologic and Mental Disease
  • Author : Liana Fattore
  • Publisher : Academic Press
  • Release : 23 January 2015
GET THIS BOOKCannabinoids in Neurologic and Mental Disease

The application of cannabis sativa for the treatment of neurologic and mental disease is expanding. Cannabinoids in Neurologic and Mental Disease collects and presents for the first time recent research involving the use of pharmacological cannabinoids for the treatment of neurodegenerative and neuroinflammatory disease. The neurologic application of cannabinoid therapy builds upon psychiatric and psychological use for the treatment of a variety of core mental disorders. This comprehensive reference on the known uses of cannabinoids will be useful for clinical

Superacid Chemistry

Superacid Chemistry
  • Author : George A. Olah,G. K. Surya Prakash,Jean Sommer,Arpad Molnar
  • Publisher : John Wiley & Sons
  • Release : 26 March 2009
GET THIS BOOKSuperacid Chemistry

The chemistry of superacids has developed in the last two decades into a field of growing interest and importance. Now available in a new expanded second edition, this definitive work on superacids offers a comprehensive review of superacids and discusses the development of new superacid systems and applications of superacids in the promotion of unusual reactions. Covering Bronsted and Leurs superacids, solid superacids, carbocations, heterocations, and catalyzed reactions, this timely volume is invaluable to professionals, faculty, and graduate students in

Amide Bond Activation

Amide Bond Activation
  • Author : Michal Szostak
  • Publisher : MDPI
  • Release : 12 July 2019
GET THIS BOOKAmide Bond Activation

The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances

Recent Advances in Redox Active Plant and Microbial Products

Recent Advances in Redox Active Plant and Microbial Products
  • Author : Claus Jacob,Gilbert Kirsch,Alan Slusarenko,Paul G. Winyard,Torsten Burkholz
  • Publisher : Springer
  • Release : 25 November 2014
GET THIS BOOKRecent Advances in Redox Active Plant and Microbial Products

Nature endows us with a treasure chest of Green Gold full of amazing ‘redox-active’ substances which interfere with numerous biological processes in our own body, in animals, bacteria, fungi and plants. Whilst such natural products are all around and also in us, we still do not fully understand how these compounds actually work. This book attempts to resolve some of the mysteries and riddles associated with such products. Written by more than thirty international experts from academia and industry, it

Contaminants in the Subsurface

Contaminants in the Subsurface
  • Author : National Research Council,Division on Earth and Life Studies,Water Science and Technology Board,Committee on Source Removal of Contaminants in the Subsurface
  • Publisher : National Academies Press
  • Release : 23 April 2005
GET THIS BOOKContaminants in the Subsurface

At hundreds of thousands of commercial, industrial, and military sites across the country, subsurface materials including groundwater are contaminated with chemical waste. The last decade has seen growing interest in using aggressive source remediation technologies to remove contaminants from the subsurface, but there is limited understanding of (1) the effectiveness of these technologies and (2) the overall effect of mass removal on groundwater quality. This report reviews the suite of technologies available for source remediation and their ability to reach a variety