Long Non coding RNA

The dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms. This book offers a large review about the long non-coding RNA It presents the broad functional diversities of those molecules It presents pioneer works from the field Provides a comprehensive review of the field Presents fundamental and therapeutic interests

Produk Detail:

  • Author : Antonin Morillon
  • Publisher : Elsevier
  • Pages : 190 pages
  • ISBN : 0081023553
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKLong Non coding RNA

Long Non-coding RNA

Long Non-coding RNA
  • Author : Antonin Morillon
  • Publisher : Elsevier
  • Release : 01 February 2018
GET THIS BOOKLong Non-coding RNA

The dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad

Long Non-Coding RNA

Long Non-Coding RNA
  • Author : Syed Mudasir Andrabi,Nazir Ahmad Ganai
  • Publisher : Cambridge Scholars Publishing
  • Release : 03 September 2020
GET THIS BOOKLong Non-Coding RNA

Long non-coding RNAs (LncRNAs) were originally regarded as “noise” in the genome due to their lack of protein-encoding capacity. However, their roles are now understood to cover various biological functions like gene regulation, cell proliferation, survival, differentiation, and chromatin remodeling. As an emerging group of non-coding RNA molecules, LncRNAs are involved in diverse diseases like cancer, cardiovascular, autoimmune, hormonal disorders, neurodegeneration, and infection, among others. However, knowledge of the mechanisms by which they act is still ambiguous. As such, this

Long Noncoding RNAs in Plants

Long Noncoding RNAs in Plants
  • Author : Santosh Kumar Upadhyay
  • Publisher : Academic Press
  • Release : 13 November 2020
GET THIS BOOKLong Noncoding RNAs in Plants

The growth of human population has increased the demand for improved yield and quality of crops and horticultural plants. However, plant productivity continues to be threatened by stresses such as heat, cold, drought, heavy metals, UV radiations, bacterial and fungal pathogens, and insect pests. Long noncoding RNAs are associated with various developmental pathways, regulatory systems, abiotic and biotic stress responses and signaling, and can provide an alternative strategy for stress management in plants. Long Noncoding RNAs in Plants: Roles in

Long Non Coding RNA Biology

Long Non Coding RNA Biology
  • Author : M.R.S. Rao
  • Publisher : Springer
  • Release : 16 August 2017
GET THIS BOOKLong Non Coding RNA Biology

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.

Long Non-Coding RNAs in Cancer

Long Non-Coding RNAs in Cancer
  • Author : Alfons Navarro
  • Publisher : Unknown Publisher
  • Release : 29 May 2022
GET THIS BOOKLong Non-Coding RNAs in Cancer

This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery

Genomic Elements in Health, Disease and Evolution

Genomic Elements in Health, Disease and Evolution
  • Author : Kyriacos Felekkis,Konstantinos Voskarides
  • Publisher : Springer
  • Release : 30 September 2015
GET THIS BOOKGenomic Elements in Health, Disease and Evolution

Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the “junk” DNA since it does not code for any “useful” protein product. Over the last years this notion changed significantly as scientists discovered that a large part of this DNA contains various genomic elements that have important roles in cell physiology. Genomic elements such as non-coding RNAs, transposons, splicing RNAs, DNA repeats and others were shown to

Molecular Biology of Long Non-coding RNAs

Molecular Biology of Long Non-coding RNAs
  • Author : Ahmad M. Khalil,Jeff Coller
  • Publisher : Springer Science & Business Media
  • Release : 20 September 2013
GET THIS BOOKMolecular Biology of Long Non-coding RNAs

​Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. ​So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA

Gene Expression Profiling in Cancer

Gene Expression Profiling in Cancer
  • Author : Dimitrios Vlachakis
  • Publisher : BoD – Books on Demand
  • Release : 19 June 2019
GET THIS BOOKGene Expression Profiling in Cancer

The contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new techniques for treating various diseases that affect humanity. Methods for finding and analyzing the profile of gene expression of infected cells give scientists the ability to develop more targeted and effective treatments, especially for diseases such as cancer. The development of gene expression profiling is one of

Plant Long Non-Coding RNAs

Plant Long Non-Coding RNAs
  • Author : Julia A. Chekanova,Hsiao-Lin V. Wang
  • Publisher : Humana Press
  • Release : 20 April 2019
GET THIS BOOKPlant Long Non-Coding RNAs

This volume focuses on various approaches to studying long non-coding RNAs (lncRNAs), including techniques for finding lncRNAs, localization, and observing their functions. The chapters in this book cover how to catalog lncRNAs in various plant species; determining subcellular localization; protein interactions; structures; and RNA modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and

Computational Non-coding RNA Biology

Computational Non-coding RNA Biology
  • Author : Yun Zheng
  • Publisher : Academic Press
  • Release : 14 September 2018
GET THIS BOOKComputational Non-coding RNA Biology

Computational Non-coding RNA Biology is a resource for the computation of non-coding RNAs. The book covers computational methods for the identification and quantification of non-coding RNAs, including miRNAs, tasiRNAs, phasiRNAs, lariat originated circRNAs and back-spliced circRNAs, the identification of miRNA/siRNA targets, and the identification of mutations and editing sites in miRNAs. The book introduces basic ideas of computational methods, along with their detailed computational steps, a critical component in the development of high throughput sequencing technologies for identifying different

Cancer and Noncoding RNAs

Cancer and Noncoding RNAs
  • Author : Jayprokas Chakrabarti,Sanga Mitra
  • Publisher : Academic Press
  • Release : 13 October 2017
GET THIS BOOKCancer and Noncoding RNAs

Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail

Transcriptional and Post-transcriptional Regulation

Transcriptional and Post-transcriptional Regulation
  • Author : Ghedira Kais
  • Publisher : BoD – Books on Demand
  • Release : 10 October 2018
GET THIS BOOKTranscriptional and Post-transcriptional Regulation

This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes

Neurotrophic Factors

Neurotrophic Factors
  • Author : Gary R. Lewin,Bruce D. Carter
  • Publisher : Springer Science & Business Media
  • Release : 25 March 2014
GET THIS BOOKNeurotrophic Factors

This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of

Advances in Bioinformatics and Computational Biology

Advances in Bioinformatics and Computational Biology
  • Author : Carlos E. Ferreira,Satoru Miyano,Peter F. Stadler
  • Publisher : Springer Science & Business Media
  • Release : 18 August 2010
GET THIS BOOKAdvances in Bioinformatics and Computational Biology

This book constitutes the proceedings of the 5th Brazilian Symposium on Bioinformatics, BSB 2010, held in Rio de Janeiro, Brazil, in August/September 2010. The 5 full papers and 5 extended abstracts presented were carefully reviewed and selected for inclusion in the book. The topics of interest vary in many areas of Bioinformatics, including sequence analysis, motifs, and pattern matching; biomedical text mining; biological databases, data management, integration; biological data mining; structural, comparative, and functional genomics; protein structure, modeling and simulation; gene identification, and