Macrophages Biology and Role in the Pathology of Diseases

Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.

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  • Author : Subhra K. Biswas
  • Publisher : Springer
  • Pages : 615 pages
  • ISBN : 1493913115
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKMacrophages Biology and Role in the Pathology of Diseases

Macrophages: Biology and Role in the Pathology of Diseases

Macrophages: Biology and Role in the Pathology of Diseases
  • Author : Subhra K. Biswas,Alberto Mantovani
  • Publisher : Springer
  • Release : 12 November 2014
GET THIS BOOKMacrophages: Biology and Role in the Pathology of Diseases

Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to

Macrophages and their Role in Inflammation

Macrophages and their Role in Inflammation
  • Author : Jae Youl Cho
  • Publisher : Academic Press
  • Release : 01 September 2021
GET THIS BOOKMacrophages and their Role in Inflammation

In recent years, researchers around the globe have deep dived into the fascination world of the Macrophage and its diverse role in tissue development, angiogenesis, and wound healing, and above all the untapped mystery of the wondering immune system within our body. Macrophages and their role in inflammation includes all the latest information of macrophages and inflammation as well as it provides an in-depth understanding of this complex and rapidly progressing field of study. Outlines the role of macrophages in

The Resolution of Inflammation

The Resolution of Inflammation
  • Author : Adriano Rossi,Deborah A. Sawatzky
  • Publisher : Springer Science & Business Media
  • Release : 17 March 2008
GET THIS BOOKThe Resolution of Inflammation

This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Janeway's Immunobiology

Janeway's Immunobiology
  • Author : Murphy, Kenneth M.,Weaver, Casey
  • Publisher : W.W. Norton & Company
  • Release : 22 March 2016
GET THIS BOOKJaneway's Immunobiology

Explore the premier text for immunology at the advanced undergraduate, graduate, and medical school levels. Beginning students appreciate the bookÕs clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope and depth. This edition is thoroughly revised and up to date with significant developments in the field, especially on the topic of innate immunity.

Immunobiology of the Macrophage

Immunobiology of the Macrophage
  • Author : David S. Nelson
  • Publisher : Academic Press
  • Release : 28 June 2014
GET THIS BOOKImmunobiology of the Macrophage

Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book’s contributors—immunologists of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed

The Inflammasomes

The Inflammasomes
  • Author : Isabelle Couillin,Virginie Pétrilli,Fabio Martinon
  • Publisher : Springer Science & Business Media
  • Release : 02 July 2011
GET THIS BOOKThe Inflammasomes

The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense

Myeloid Cells in Health and Disease

Myeloid Cells in Health and Disease
  • Author : Siamon Gordon
  • Publisher : John Wiley & Sons
  • Release : 10 July 2020
GET THIS BOOKMyeloid Cells in Health and Disease

The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis,

Heat Shock Proteins: Potent Mediators of Inflammation and Immunity

Heat Shock Proteins: Potent Mediators of Inflammation and Immunity
  • Author : Alexzander A.A. Asea,Antonio De Maio
  • Publisher : Springer Science & Business Media
  • Release : 05 September 2007
GET THIS BOOKHeat Shock Proteins: Potent Mediators of Inflammation and Immunity

This book provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulate the hosts’ immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step-wise fashion take the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provide answers as to its biological significance to the host.

Biology of Myelomonocytic Cells

Biology of Myelomonocytic Cells
  • Author : Anirban Ghosh
  • Publisher : BoD – Books on Demand
  • Release : 10 May 2017
GET THIS BOOKBiology of Myelomonocytic Cells

Myelomonocytes are the multipotent cells in the stage of blood cell differentiation, which mainly comprise blood monocytes, tissue macrophages and subset of dendritic cells. Actually, their position and ability of judgement of the health of tissue or organ environment are the key initiators of tissue-specific immune response in a local and global fashion. Interestingly, the morpho-functional aspects of this group of cells vary to a wide range with their positional diversity. Their ability to communicate or represent the tissue microenvironment

Hot Topics in Burn Injuries

Hot Topics in Burn Injuries
  • Author : Selda Pelin Kartal,Dilek Bayramgurler
  • Publisher : BoD – Books on Demand
  • Release : 23 May 2018
GET THIS BOOKHot Topics in Burn Injuries

The aim of this book is to give readers a broad review of burn injuries, which may affect people from birth to death and can lead to high morbidity and mortality. The book consists of four sections and seven chapters. The first section consists of the introductory review chapter, which overviews the burn injuries. The second section includes chapter "Burn Etiology and Pathogenesis," which focuses on burn injuries and clinical findings. The third section consists of chapter "Controlling Inflammation in

Ilya Mechnikov

Ilya Mechnikov
  • Author : Semyon Zalkind
  • Publisher : The Minerva Group, Inc.
  • Release : 01 September 2001
GET THIS BOOKIlya Mechnikov

A biography of Nobel laureate Ilya Mechnikov (1845 - 1916), a Russian biologist and a founder of the science of immunity. Mechnikov is one of those famous Russian scientists who, like Mendeleyev, Butlerov, Sechenov, Pavlov, the Kovalevsky brothers, and Timiryazev, are the pride of Russian science. He was a Darwinian scientist who had theories of cellular immunity, applications of phagocytic theory and the biological doctrine of inflammation.Mechnikov was born in Kharkiv Oblast (now Ukraine) on May 15, 1845. He was educated at the

Antigens, Lymphoid Cells and the Immune Response

Antigens, Lymphoid Cells and the Immune Response
  • Author : G. J. V. Nossal,G L Ada
  • Publisher : Academic Press
  • Release : 28 June 2014
GET THIS BOOKAntigens, Lymphoid Cells and the Immune Response

Antigens, Lymphoid Cells, and the Immune Response deals with the nature and properties of antigens and with the functional anatomy and cell physiology of the mammalian lymphoid system which responds to antigens. The book discusses the central questions in cellular immunology; the antigens and the afferent limb of the immune response; and antibodies and the afferent limb of the immune response. The text also describes the organ distribution of antigens; the functional anatomy of the lymphoid system; and the behavior

Biology of the Lymphokines

Biology of the Lymphokines
  • Author : Stanley Cohen,Edgar Pick,Joost J. Oppenheim
  • Publisher : Academic Press
  • Release : 17 September 2013
GET THIS BOOKBiology of the Lymphokines

Biology of the Lymphokines discusses the scope and diversity of lymphokine research. This book focuses on the studies on lymphokines, such as those involving cellular source, chemical nature, purification strategies, and bioassay limitations. The mechanism of lymphokine action, lymphokines in vivo, and value of lymphokine quantitations are also covered. This text describes the repertoire of lymphokines produced by various lymphoblastoid cell lines and its significance for coping with the problem of large scale lymphokine production. The anti-viral and general immunoregulatory