Macrophages Biology and Role in the Pathology of Diseases

Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.

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  • Author : Subhra K. Biswas
  • Publisher : Springer
  • Pages : 615 pages
  • ISBN : 1493913115
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKMacrophages Biology and Role in the Pathology of Diseases

Macrophages: Biology and Role in the Pathology of Diseases

Macrophages: Biology and Role in the Pathology of Diseases
  • Author : Subhra K. Biswas,Alberto Mantovani
  • Publisher : Springer
  • Release : 12 November 2014
GET THIS BOOKMacrophages: Biology and Role in the Pathology of Diseases

Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to

Janeway's Immunobiology

Janeway's Immunobiology
  • Author : Murphy, Kenneth M.,Weaver, Casey
  • Publisher : W.W. Norton & Company
  • Release : 22 March 2016
GET THIS BOOKJaneway's Immunobiology

Explore the premier text for immunology at the advanced undergraduate, graduate, and medical school levels. Beginning students appreciate the bookÕs clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope and depth. This edition is thoroughly revised and up to date with significant developments in the field, especially on the topic of innate immunity.

M1/M2 Macrophages: The Arginine Fork in the Road to Health and Disease

M1/M2 Macrophages: The Arginine Fork in the Road to Health and Disease
  • Author : Charles Dudley Mills,Laurel L Lenz,Klaus Ley
  • Publisher : Frontiers Media SA
  • Release : 23 March 2015
GET THIS BOOKM1/M2 Macrophages: The Arginine Fork in the Road to Health and Disease

Macrophages have unique and diverse functions necessary for survival. And, in humans (and other species), they are the most abundant leukocytes in tissues. The Innate functions of macrophages that are best known are their unusual ability to either “Kill” or “Repair”. Since killing is a destructive process and repair is a constructive process, it was stupefying how one cell could exhibit these 2 polar – opposite functions. However, in the late 1980’s, it was shown that macrophages have a unique ability to

Myeloid Cells in Health and Disease

Myeloid Cells in Health and Disease
  • Author : Siamon Gordon
  • Publisher : John Wiley & Sons
  • Release : 10 July 2020
GET THIS BOOKMyeloid Cells in Health and Disease

The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis,

The Resolution of Inflammation

The Resolution of Inflammation
  • Author : Adriano Rossi,Deborah A. Sawatzky
  • Publisher : Springer Science & Business Media
  • Release : 17 March 2008
GET THIS BOOKThe Resolution of Inflammation

This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Immunobiology 5 : the Immune System in Health and Disease

Immunobiology 5 : the Immune System in Health and Disease
  • Author : Charles Janeway,Paul Travers,Mark Walport,Mark Schlomchik
  • Publisher : Garland Science
  • Release : 12 April 2021
GET THIS BOOKImmunobiology 5 : the Immune System in Health and Disease

Designed for providers who work with judicial clients, the Providers Guide presents effective cognitive-behavioral treatment approaches. The Second Edition of this bestseller unveils a state-of-the-art approach for effectively preventing criminal recidivism and substance abuse relapse within community based and correctional settings. The core of the SSC program is a positive relationship between provider and client. Summary of results survey from the first edition of SSC 95% of the providers rated the components of SSC to be adequate to very adequate in

The Metabolic Challenges of Immune Cells in Health and Disease

The Metabolic Challenges of Immune Cells in Health and Disease
  • Author : Claudio Mauro,Christian Frezza
  • Publisher : Unknown Publisher
  • Release : 13 July 2015
GET THIS BOOKThe Metabolic Challenges of Immune Cells in Health and Disease

Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work highlighted the contribution of macrophages to tissue inflammation and insulin resistance, recent studies demonstrate that cells of the adaptive immune compartment, including T and B lymphocytes and dendritic cells also participate in obesity-induced pathogenesis of these conditions. However, the molecular and cellular pathways by which the innate

Immunity and Inflammation in Health and Disease

Immunity and Inflammation in Health and Disease
  • Author : Shampa Chatterjee,Wolfgang Jungraithmayr,Debasis Bagchi
  • Publisher : Academic Press
  • Release : 31 August 2017
GET THIS BOOKImmunity and Inflammation in Health and Disease

Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells

Adipose Tissue in Health and Disease

Adipose Tissue in Health and Disease
  • Author : Todd Leff,James G. Granneman
  • Publisher : John Wiley & Sons
  • Release : 19 March 2010
GET THIS BOOKAdipose Tissue in Health and Disease

This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the

Biology of Myelomonocytic Cells

Biology of Myelomonocytic Cells
  • Author : Anirban Ghosh
  • Publisher : BoD – Books on Demand
  • Release : 10 May 2017
GET THIS BOOKBiology of Myelomonocytic Cells

Myelomonocytes are the multipotent cells in the stage of blood cell differentiation, which mainly comprise blood monocytes, tissue macrophages and subset of dendritic cells. Actually, their position and ability of judgement of the health of tissue or organ environment are the key initiators of tissue-specific immune response in a local and global fashion. Interestingly, the morpho-functional aspects of this group of cells vary to a wide range with their positional diversity. Their ability to communicate or represent the tissue microenvironment

Macrophages

Macrophages
  • Author : Malgorzata Kloc
  • Publisher : Springer
  • Release : 26 April 2017
GET THIS BOOKMacrophages

This volume gives a state-of-the-art overview on macrophage functions in various invertebrate and vertebrate systems and diseases. It also covers various aspects of macrophage development and formation, behavior and response to nano- and biomaterials, the latter of which have become very important components of modern medicine. Macrophages are evolutionarily conserved phagocytotic cells. In recent years macrophages have emerged as one of the most versatile cells of immune system, which, depending on the milieu and circumstance, participate in development or inhibition

The Mast Cell

The Mast Cell
  • Author : Domenico Ribatti
  • Publisher : Springer
  • Release : 11 July 2019
GET THIS BOOKThe Mast Cell

Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host