Mass Spectrometry for the Clinical Laboratory

Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

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  • Author : Hari Nair
  • Publisher : Academic Press
  • Pages : 304 pages
  • ISBN : 0128009926
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKMass Spectrometry for the Clinical Laboratory

Mass Spectrometry for the Clinical Laboratory

Mass Spectrometry for the Clinical Laboratory
  • Author : Hari Nair,William Clarke
  • Publisher : Academic Press
  • Release : 02 November 2016
GET THIS BOOKMass Spectrometry for the Clinical Laboratory

Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros

Mass Spectrometry for the Clinical Laboratory

Mass Spectrometry for the Clinical Laboratory
  • Author : Hari Nair
  • Publisher : Academic Press
  • Release : 01 November 2016
GET THIS BOOKMass Spectrometry for the Clinical Laboratory

"Mass Spectrometry for the Clinical Laboratory" is an accessible guide to mass spectrometry and the evaluation, validation, and trouble-shooting of the most common assays seen in clinical pathology labs. It offers readers a complete set of tools for the design of assay protocol, validation of experimental designs to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. The book provides appropriate statistical tools for validation, as well as guidance on what type of

Principles and Applications of Clinical Mass Spectrometry

Principles and Applications of Clinical Mass Spectrometry
  • Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Andy Hoofnagle
  • Publisher : Elsevier
  • Release : 26 June 2018
GET THIS BOOKPrinciples and Applications of Clinical Mass Spectrometry

Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well

Clinical Applications of Mass Spectrometry in Biomolecular Analysis

Clinical Applications of Mass Spectrometry in Biomolecular Analysis
  • Author : Uttam Garg
  • Publisher : Humana Press
  • Release : 25 November 2015
GET THIS BOOKClinical Applications of Mass Spectrometry in Biomolecular Analysis

This volume provides stepwise instructions for the analysis of numerous clinically important analytes by mass spectrometry. Mass spectrometry offers clinical laboratory scientists a number of advantages including increased sensitivity and specificity, multiple component analysis, and no need for specialized reagents. The techniques described are a must for the measurement of many clinically relevant analytes in the fields of drug analysis, endocrinology, and inborn errors of metabolism. Each chapter provides a brief introduction about a specified analyte, followed by detailed instructions

Mass Spectrometry in Life Sciences and Clinical Laboratory

Mass Spectrometry in Life Sciences and Clinical Laboratory
  • Author : Goran Mitulović
  • Publisher : BoD – Books on Demand
  • Release : 02 June 2021
GET THIS BOOKMass Spectrometry in Life Sciences and Clinical Laboratory

Mass spectrometry is a state-of-the-art tool for basic biological research and applied clinical diagnostics. This book covers sample preparation for mass spectrometric analysis for proteomics, clinical studies, and food analysis. In addition, it explores possible directions for further developing the technology and its potential applications.

Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines

Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines
  • Author : Aihua Zhang,Wanying Wang
  • Publisher : John Wiley & Sons
  • Release : 20 August 2021
GET THIS BOOKMass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines

Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of

Clinical Chemistry, Immunology and Laboratory Quality Control

Clinical Chemistry, Immunology and Laboratory Quality Control
  • Author : Amitava Dasgupta,Amer Wahed
  • Publisher : Academic Press
  • Release : 02 December 2013
GET THIS BOOKClinical Chemistry, Immunology and Laboratory Quality Control

All pathology residents must have a good command of clinical chemistry, toxicology, immunology, and laboratory statistics to be successful pathologists, as well as to pass the American Board of Pathology examination. Clinical chemistry, however, is a topic in which many senior medical students and pathology residents face challenges. Clinical Chemistry, Immunology and Laboratory Quality Control meets this challenge head on with a clear and easy-to-read presentation of core topics and detailed case studies that illustrate the application of clinical chemistry

Analytical Techniques for Clinical Chemistry

Analytical Techniques for Clinical Chemistry
  • Author : Sergio Caroli,Gyula Záray
  • Publisher : John Wiley & Sons
  • Release : 26 June 2012
GET THIS BOOKAnalytical Techniques for Clinical Chemistry

Discover how analytical chemistry supports the latest clinical research This book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors' careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab. Analytical Techniques for Clinical Chemistry opens with

Contemporary Practice in Clinical Chemistry

Contemporary Practice in Clinical Chemistry
  • Author : William Clarke,Mark Marzinke
  • Publisher : Academic Press
  • Release : 11 June 2020
GET THIS BOOKContemporary Practice in Clinical Chemistry

Contemporary Practice in Clinical Chemistry, Fourth Edition, provides a clear and concise overview of important topics in the field. This new edition is useful for students, residents and fellows in clinical chemistry and pathology, presenting an introduction and overview of the field to assist readers as they in review and prepare for board certification examinations. For new medical technologists, the book provides context for understanding the clinical utility of tests that they perform or use in other areas in the

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology
  • Author : Fernando Cobo
  • Publisher : Academic Press
  • Release : 03 August 2018
GET THIS BOOKThe Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification

Medical Applications of Mass Spectrometry

Medical Applications of Mass Spectrometry
  • Author : Karoly Vekey,Andreas Telekes,Akos Vertes
  • Publisher : Elsevier
  • Release : 11 August 2011
GET THIS BOOKMedical Applications of Mass Spectrometry

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to

Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book

Mass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book
  • Author : Nigel Clarke,Andrew N. Hoofnagle
  • Publisher : Elsevier Health Sciences
  • Release : 03 October 2011
GET THIS BOOKMass Spectrometry, An Issue of Clinics in Laboratory Medicine - E-Book

This issue of Clinics in Laboratory Medicine, Guest Edited by Nigel Clarke, MD, and Andrew Hoofnagle, MD, will focus on Mass Spectrometry, with topics including: Proteins; Peptides; Small Molecules: Toxicology; Small Molecules: Diagnostics; and Regulatory Considerations.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics
  • Author : Nader Rifai
  • Publisher : Elsevier Health Sciences
  • Release : 16 January 2017
GET THIS BOOKTietz Textbook of Clinical Chemistry and Molecular Diagnostics

The Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition provides the most current and authoritative guidance on selecting, performing, and evaluating the results of new and established laboratory tests. This classic clinical chemistry reference offers encyclopedic coverage detailing everything you need to know, including: analytical criteria for the medical usefulness of laboratory tests, variables that affect tests and results, laboratory medicine, applications of statistical methods, and most importantly clinical utility and interpretation of laboratory tests. It is THE

Clinical Applications of Mass Spectrometry in Drug Analysis

Clinical Applications of Mass Spectrometry in Drug Analysis
  • Author : Uttam Garg
  • Publisher : Humana Press
  • Release : 11 December 2015
GET THIS BOOKClinical Applications of Mass Spectrometry in Drug Analysis

This volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Chapters in the book cover a wide array of topics such as: quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma; quantitation of total Buprenorphine and Norbuprenorphine in Meconium; quantitation or Carisoprodol and Meprobamate in Urine; and quantitation of Tricyclic Antidepressants in Serum. Each chapter contains a brief introduction to the topic, clinical utility of the analyte(s), and useful notes