Models of Protection Against HIV SIV

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field

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  • Author : Gianfranco Pancino
  • Publisher : Academic Press
  • Pages : 345 pages
  • ISBN : 0123877156
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKModels of Protection Against HIV SIV

Models of Protection Against HIV/SIV

Models of Protection Against HIV/SIV
  • Author : Gianfranco Pancino,Guido Silvestri,Keith R. Fowke
  • Publisher : Academic Press
  • Release : 01 January 2012
GET THIS BOOKModels of Protection Against HIV/SIV

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature

Natural Hosts of SIV

Natural Hosts of SIV
  • Author : Aftab A. Ansari,Guido Silvestri
  • Publisher : Newnes
  • Release : 04 July 2014
GET THIS BOOKNatural Hosts of SIV

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural

Health of HIV Infected People

Health of HIV Infected People
  • Author : Ronald Ross Watson
  • Publisher : Academic Press
  • Release : 29 April 2015
GET THIS BOOKHealth of HIV Infected People

Health of HIV Infected People: Food, Nutrition and Lifestyle Without Antiretroviral Drugs defines the supportive roles of bioactive foods, exercise, and dietary supplements on the health of HIV infected people who do not have access to resources or those who choose not to utilize antiretroviral drugs. Approaches such as the application of traditional herbs and foods are given careful definition by experts who define the risks and benefits of such practices within this important context. Readers learn how to treat

AIDS Research at EC Level

AIDS Research at EC Level
  • Author : Andre E. Baert
  • Publisher : IOS Press
  • Release : 19 January 1995
GET THIS BOOKAIDS Research at EC Level

At EC level the fight against AIDS, one of the major health problems and socioeconomic diseases today, is also part of the specific RTD programme in the field of biomedicine and health. About 600 research teams are collaborating within 30 concerted actions networks that are underpinned by centralised facilities. For example, the epidemiology research networks are monitored by the WHO/EC collaborating centre in St. Maurice, France. Common experiments on animal models, antiviral screening, genetic analysis of multiple virus strains and provision

In vivo Models of HIV Disease and Control

In vivo Models of HIV Disease and Control
  • Author : Herman Friedman,Steven Specter,Mauro Bendinelli
  • Publisher : Springer Science & Business Media
  • Release : 27 April 2007
GET THIS BOOKIn vivo Models of HIV Disease and Control

An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV. Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development,

Cellular Immunity Among HIV Exposed, Uninfected Individuals

Cellular Immunity Among HIV Exposed, Uninfected Individuals
  • Author : George Makedonas
  • Publisher : Unknown Publisher
  • Release : 19 January 2022
GET THIS BOOKCellular Immunity Among HIV Exposed, Uninfected Individuals

"Two models of HIV infection have been studied extensively with the goal of identifying immune correlate(s) of protection against HIV: (1) the simian immunodeficiency virus (SIV) infection of rhesus macaque monkeys and (2) individuals with repeated exposure to HIV who remain uninfected by the virus (EUs). Both paradigms suggest that T cell-mediated immunity plays an important role in controlling HIV replication. Evidence from the SIV/macaque system, however, predicts that HIV vaccines aimed at eliciting T cell responses will fail to

Estimating the Impact of Vaccination in Acute SHIV-SIV Infection

Estimating the Impact of Vaccination in Acute SHIV-SIV Infection
  • Author : Anonim
  • Publisher : Unknown Publisher
  • Release : 19 January 2022
GET THIS BOOKEstimating the Impact of Vaccination in Acute SHIV-SIV Infection

Human Immunodeficiency Virus (HIV) infects approxmately 0.5% of the world population, and is a major cause of morbidity and mortality worldwide. A vaccine for HIV is urgently required, and a variety of vaccine modalities have been tested in animal models of infection. A number of these studies have shown protection in monkey models of infection, although the ability of the vaccine to protect appears to vary with the viral strain and animal model used. The recent failure of a large vaccine

Adverse reactions to HIV vaccines : medical, ethical, and legal issues.

Adverse reactions to HIV vaccines : medical, ethical, and legal issues.
  • Author : Anonim
  • Publisher : DIANE Publishing
  • Release : 19 January 1995
GET THIS BOOKAdverse reactions to HIV vaccines : medical, ethical, and legal issues.

AIDS researchers are investigating new vaccines that would prevent infection with HIV and reduce the spread of AIDS. Some have argued that product liability concerns have discouraged investment in HIV vaccine research and development. The purpose of this OTA background paper is to describe the current state of development of HIV vaccines, and to discuss what is known about adverse reactions that may occur. The background paper provides an overview of ethical issues that arise in the conduct of HIV

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Sara I. Ruiz,Elizabeth E. Zumbrun,Aysegul Nalca
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

As the threat of exposure to emerging and reemerging viruses within a naive population increases, it is vital that the basic mechanisms of pathogenesis and immune response be thoroughly investigated. By using animal models in this endeavor, the response to viruses can be studied in a more natural context to identify novel drug targets, and assess the efficacy and safety of new products. This is especially true in the advent of the Food and Drug Administration's animal rule. Although no

Novel Strategies in the Design and Production of Vaccines

Novel Strategies in the Design and Production of Vaccines
  • Author : Sara Cohen,Avigdor Shafferman
  • Publisher : Springer Science & Business Media
  • Release : 29 June 2013
GET THIS BOOKNovel Strategies in the Design and Production of Vaccines

Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic

AIDS and Other Manifestations of HIV Infection

AIDS and Other Manifestations of HIV Infection
  • Author : Gary Wormser
  • Publisher : Elsevier
  • Release : 18 February 2004
GET THIS BOOKAIDS and Other Manifestations of HIV Infection

Extensively revised and updated, the new edition of AIDS and Other Manifestations of HIV Infection is an essential reference resource providing a comprehensive overview of the biological properties of this etiologic viral agent, its clinicopathological manifestations, the epidemiology of its infection, and present and future therapeutic options. Expanded section on clinical manifestations includes new chapters on cardiovascular, renal and dermatologic manifestations of HIV infection Additional chapters on molecular diagnostic techniques, the role of host genetic variation in HIV infection and

Experimental Animal Models of Human Diseases

Experimental Animal Models of Human Diseases
  • Author : Bartholomew Ibeh
  • Publisher : BoD – Books on Demand
  • Release : 23 May 2018
GET THIS BOOKExperimental Animal Models of Human Diseases

The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches

Human Immunodeficiency Virus type 1 (HIV-1) and Breastfeeding

Human Immunodeficiency Virus type 1 (HIV-1) and Breastfeeding
  • Author : Athena P. Kourtis,Marc Bulterys
  • Publisher : Springer Science & Business Media
  • Release : 28 March 2012
GET THIS BOOKHuman Immunodeficiency Virus type 1 (HIV-1) and Breastfeeding

The HIV pandemic continues to levy a heavy burden on the human race world-wide. The estimated number of people who became newly infected with HIV in 2009 was 2.6 million; most of these individuals live in Sub-Saharan Africa, followed by India and Southeast Asia. An estimated 370,000 new cases of pediatric infections occurred globally in 2009 (or more than 1,000 new infections every day), practically all of them through mother-to-child transmission. Up to 40% of all new infant HIV infections occur during breastfeeding. While breastfeeding by