Models of Seizures and Epilepsy

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

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  • Author : Asla Pitkänen
  • Publisher : Academic Press
  • Pages : 1178 pages
  • ISBN : 012804067X
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKModels of Seizures and Epilepsy

Models of Seizures and Epilepsy

Models of Seizures and Epilepsy
  • Author : Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé
  • Publisher : Academic Press
  • Release : 14 June 2017
GET THIS BOOKModels of Seizures and Epilepsy

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of

Encyclopedia of Basic Epilepsy Research

Encyclopedia of Basic Epilepsy Research
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 27 May 2009
GET THIS BOOKEncyclopedia of Basic Epilepsy Research

As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent

Experimental Models of Epilepsy and Related Comorbidities

Experimental Models of Epilepsy and Related Comorbidities
  • Author : Mohd. Farooq Shaikh,Ayanabha Chakraborti,Annamaria Vezzani,Jafri Malin Abdullah
  • Publisher : Frontiers Media SA
  • Release : 19 June 2019
GET THIS BOOKExperimental Models of Epilepsy and Related Comorbidities

Epileptic patients live with epilepsy-associated complications such as cognitive dysfunction, psychological discomfort, and sexual function decline, and are more likely to experience emotional and mental health issues problems, including depression and anxiety. Many antiepileptic drugs are found to have a role in aggravating psychiatric symptoms. Animal models, which inform translational questions about epilepsy comorbidities, are used to study the relationship between epilepsy and related comorbidities. The aim of this Research Topic was to highlight basic, clinical and interdisciplinary research involved

Animal Models of Epilepsy

Animal Models of Epilepsy
  • Author : Scott C. Baraban
  • Publisher : Unknown Publisher
  • Release : 01 January 2009
GET THIS BOOKAnimal Models of Epilepsy

Animal models provide a means to investigate fundamental mechanisms of abnormal electrical discharge i.e., seizures. Taking advantage of transgenic and homologous recombination techniques, laboratories have recently moved beyond the standard convulsant or stimulation models in rat to develop novel mouse models of epilepsy. This book provides a review of the current and emerging animal models used to study epilepsy. Prior textbooks devoted to models of seizure and epilepsy almost exclusively categorized rat models with little attention paid to these

Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies
  • Author : Jeffrey Noebels,Massimo Avoli,Michael Rogawski,Richard Olsen,Antonio Delgado-Escueta
  • Publisher : Oxford University Press
  • Release : 01 June 2012
GET THIS BOOKJasper's Basic Mechanisms of the Epilepsies

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these

Neuropharmacology Methods in Epilepsy Research

Neuropharmacology Methods in Epilepsy Research
  • Author : Steven L. Peterson,Timothy E. Albertson
  • Publisher : CRC Press
  • Release : 07 May 2019
GET THIS BOOKNeuropharmacology Methods in Epilepsy Research

There is an estimated 2.5 million epileptics in the US and perhaps some 40 million worldwide. As research has become increasingly molecular in scope, fewer scientists are trained in the US on basic, integrated epilepsy techniques. One frustration in neuroscience today is the application of state-of-the-art molecular biology techniques to inappropriate animal models of epilepsy - frequently resulting in inconclusive results. Epilepsy research will be increasingly undertaken by scientists well-trained in reductionist methodology, but who may be unfamiliar with integrated, whole-animal techniques.

Astrocytes and Epilepsy

Astrocytes and Epilepsy
  • Author : Jacqueline A. Hubbard,Devin K. Binder
  • Publisher : Academic Press
  • Release : 05 July 2016
GET THIS BOOKAstrocytes and Epilepsy

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of

Behavioral Aspects of Epilepsy

Behavioral Aspects of Epilepsy
  • Author : Gregory L. Holmes, MD,Steven C. Schachter,Dr. Dorothee GA Kasteleijn-Nolst Trenite, "MD,MPH"
  • Publisher : Demos Medical Publishing
  • Release : 15 October 2007
GET THIS BOOKBehavioral Aspects of Epilepsy

The field of epilepsy and behavior has grown considerably in the past number of years, reflecting advances in the laboratory and clinic. Behavioral Aspects of Epilepsy: Principles and Practice is the definitive text on epilepsy behavioral issues, from basic science to clinical applications, for all neurologists, psychosocial specialists, and researchers in the fields of epilepsy, neuroscience, and psychology/psychiatry. Behavioral aspects of epilepsy include a patient's experiences during seizures, his or her reaction during and between seizures, the frequency of

Epileptic Seizures and the EEG

Epileptic Seizures and the EEG
  • Author : Andrea Varsavsky,Iven Mareels,Mark Cook
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKEpileptic Seizures and the EEG

A study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically based dynamic

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury
  • Author : Daniel Laskowitz,Gerald Grant
  • Publisher : CRC Press
  • Release : 01 December 2015
GET THIS BOOKTranslational Research in Traumatic Brain Injury

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps

Computational Neuroscience in Epilepsy

Computational Neuroscience in Epilepsy
  • Author : Ivan Soltesz,Kevin Staley
  • Publisher : Academic Press
  • Release : 02 September 2011
GET THIS BOOKComputational Neuroscience in Epilepsy

Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters

The Nervous System

The Nervous System
  • Author : Adina T. Michael-Titus,Patricia Revest,Peter Shortland
  • Publisher : Elsevier Health Sciences
  • Release : 11 April 2014
GET THIS BOOKThe Nervous System

This is an integrated textbook on the nervous system, covering the anatomy, physiology and biochemistry of the system, all presented in a clinically relevant context appropriate for the first two years of the medical student course. One of the seven volumes in the Systems of the Body series. Concise text covers the core anatomy, physiology and biochemistry in an integrated manner as required by system- and problem-based medical courses. The basic science is presented in the clinical context in a

The Causes of Epilepsy

The Causes of Epilepsy
  • Author : Simon D. Shorvon,Frederick Andermann,Renzo Guerrini
  • Publisher : Cambridge University Press
  • Release : 14 April 2011
GET THIS BOOKThe Causes of Epilepsy

Causation is an aspect of epilepsy neglected in the scientific literature and in the conceptualization of epilepsy at a clinical and experimental level. It was to remedy this deficiency that this book was conceived. The book opens with a draft etiological classification that goes some way to filling the nosological void. The book is divided into four etiological categories: idiopathic, symptomatic, cryptogenic, and provoked epilepsies. Each chapter considers topics in a consistent fashion, dealing with the phenomenon of epilepsy in

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Ryuta Koyama
  • Publisher : Elsevier Inc. Chapters
  • Release : 29 May 2013
GET THIS BOOKAnimal Models for the Study of Human Disease

Epilepsy is a nervous system disorder characterized by recurrent seizures that commonly affects infants and children. It has been suggested that prolonged seizures in early life could affect the developing brain. Thus, adequate animal models for studying the causality and outcome of early-life seizures are necessary to facilitate the development of drugs and therapeutic strategies. Among early-life seizures, febrile seizures are the most common type of convulsive events in humans between 3 months and 5 years of age. Although febrile seizures are

Epileptic Syndromes in Infancy, Childhood and Adolescence - 5th edition

Epileptic Syndromes in Infancy, Childhood and Adolescence - 5th edition
  • Author : Bureau Michelle,Genton Pierre,Dravet Charlotte
  • Publisher : John Libbey Eurotext
  • Release : 12 November 2012
GET THIS BOOKEpileptic Syndromes in Infancy, Childhood and Adolescence - 5th edition

The ultimate reference book : the 5th updated edition of the famous “blue guide”. Incluided : A DVD with new sequences completes each chapter! Epileptology changes. The syndromic approach is completed by an etiological approach, based on the major advances in genetics and functional genetics. New entities have found their place, and a purely descriptive, “electroclinical” approach is no longer adapted in many circumstances. The 5th edition of the Blue Guide includes the most recent advances. It was necessary to justify the