Molecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy

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  • Author : Nicholas M Boulis
  • Publisher : Academic Press
  • Pages : 336 pages
  • ISBN : 0128025247
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKMolecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases
  • Author : Nicholas M Boulis,Deirdre O’Connor,Anthony Donsante
  • Publisher : Academic Press
  • Release : 18 January 2017
GET THIS BOOKMolecular and Cellular Therapies for Motor Neuron Diseases

Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms.

Motor Neuron Disease in Adults

Motor Neuron Disease in Adults
  • Author : Mark Bromberg
  • Publisher : Oxford University Press
  • Release : 02 October 2014
GET THIS BOOKMotor Neuron Disease in Adults

Motor Neuron Disease in Adults reviews new information as it applies to all aspects of motor neuron disease (ALS, PLS, PMA). The choice of articles is for those that use evidence-based methods to ensure that the new information is solid and advances the topic or issue. The book can be used by anyone who provides any type of care to ALS patients. In particular, neurologists will find the latest information on diagnosis and management, as well as new information on

Novel Aspects on Motor Neuron Disease

Novel Aspects on Motor Neuron Disease
  • Author : Humberto Foyaca Sibat,Lourdes de Fátima Ibañez-Valdés
  • Publisher : BoD – Books on Demand
  • Release : 20 May 2020
GET THIS BOOKNovel Aspects on Motor Neuron Disease

Dedicated to our readers, we include novel information (not reported in IntechOpen’s books before) about new contributions of aberrant astrocytes to MND damage and death in the SOD1G93A rat experimental model of ALS; novel genetic studies on ALS; an update of the structural and functional consequences of the spinal muscular atrophy-linked mutations of the survival motor neuron protein; stem cell therapy for MND; and the novel treatment for SMA and ALS in the introductory chapter. This book

The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases
  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release : 29 March 2018
GET THIS BOOKThe Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative

Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis

Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis
  • Author : Ricardo Tapia
  • Publisher : Frontiers Media SA
  • Release : 11 February 2015
GET THIS BOOKCellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons of the cerebral cortex, brainstem and the spinal cord. The cognitive process is not affected and is not merely the result of aging because may occur at young ages. The only known cause of the disease is associated with genetic mutations, mainly in the gene encoding superoxide dismutase 1 (familial ALS),

The Future of Pharmaceuticals

The Future of Pharmaceuticals
  • Author : Sarfaraz K. Niazi
  • Publisher : CRC Press
  • Release : 01 March 2022
GET THIS BOOKThe Future of Pharmaceuticals

Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences.

CELL BIOLOGY AND TRANSLATIONAL MEDICINE

CELL BIOLOGY AND TRANSLATIONAL MEDICINE
  • Author : Kursad Turksen
  • Publisher : Springer Nature
  • Release : 22 January 2022
GET THIS BOOKCELL BIOLOGY AND TRANSLATIONAL MEDICINE

"Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as

Autophagy in Health and Disease

Autophagy in Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 30 June 2020
GET THIS BOOKAutophagy in Health and Disease

Autophagy in Health and Disease, Volume 175, presents the latest insights from renowned experts in the field who discuss the key role of autophagic responses in the preservation of cellular and organismal homeostasis and how defects in the molecular apparatus for autophagy drive or accompany disease. Specific chapters in this new release include Crosstalk between autophagy and cell death signaling: mechanisms and therapeutic relevance, C. elegans to model autophagy-related human disorders, Autophagy in Kidney Disease: advances and therapeutic potential, Autophagy in

Motor Neuron Disease

Motor Neuron Disease
  • Author : Kevin Talbot,Rachael Marsden,Rachel Botell
  • Publisher : Oxford University Press
  • Release : 22 January 2022
GET THIS BOOKMotor Neuron Disease

Written and designed to provide comprehensive, easily accessible advice for all healthcare professionals involved in the care of patients with this challenging condition, this book addresses the entire care pathway from presentation to diagnosis to symptom management and end of life issues.

Neurodegeneration

Neurodegeneration
  • Author : Dennis Dickson,Roy O. Weller
  • Publisher : John Wiley & Sons
  • Release : 09 September 2011
GET THIS BOOKNeurodegeneration

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within

TDP-43 and Neurodegeneration

TDP-43 and Neurodegeneration
  • Author : Vijay Kumar,Manoj Kumar Jaiswal
  • Publisher : Academic Press
  • Release : 23 October 2021
GET THIS BOOKTDP-43 and Neurodegeneration

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells

Spinal Muscular Atrophy

Spinal Muscular Atrophy
  • Author : Charlotte J Sumner,Sergey Paushkin,Chien-Ping Ko
  • Publisher : Academic Press
  • Release : 24 October 2016
GET THIS BOOKSpinal Muscular Atrophy

Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of

Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis
  • Author : Muralidhar L. Hegde
  • Publisher : BoD – Books on Demand
  • Release : 26 August 2020
GET THIS BOOKAmyotrophic Lateral Sclerosis

A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the

Dementia and Motor Neuron Disease

Dementia and Motor Neuron Disease
  • Author : Michael Strong
  • Publisher : CRC Press
  • Release : 27 July 2006
GET THIS BOOKDementia and Motor Neuron Disease

Dementia and Motor Neuron Disease is a single authoritative reference on the current understanding of frontotemporal dementia in amyotrophic lateral sclerosis (ALS). This comprehensive work is ideal for clinical and research groups focusing on dementia or ALS, as well as those working in the fields of neuroimaging and neuropsychology. Key topics covered include: • Frontotemporal dementia, including history, anatomy and impairment • Clinical phenomenology and treatment • Neuropathological, cognitive dysfunction and altered cognition spectrums • Neuroimaging • Molecular and cellular neuropathology • Genetics • Neurochemistry With contributions