Molecular Biological Markers for Toxicology and Risk Assessment

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice. Introduces the use of molecular biomarkers to detect toxic effects of chemicals as early as possible Provides an accessible overview of this emerging, interdisciplinary field, to best inform decision making in chemical and pharmaceutical safety Includes a section on risk communication of these complex concepts, essential for effective risk assessment Provides new insights into the initial mechanisms of chemical-induced toxicity and carcinogenicity

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  • Author : Bruce A. Fowler
  • Publisher : Academic Press
  • Pages : 164 pages
  • ISBN : 0128019018
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKMolecular Biological Markers for Toxicology and Risk Assessment

Molecular Biological Markers for Toxicology and Risk Assessment

Molecular Biological Markers for Toxicology and Risk Assessment
  • Author : Bruce A. Fowler
  • Publisher : Academic Press
  • Release : 10 June 2016
GET THIS BOOKMolecular Biological Markers for Toxicology and Risk Assessment

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced

Computational Toxicology

Computational Toxicology
  • Author : Bruce A. Fowler
  • Publisher : Academic Press
  • Release : 04 June 2013
GET THIS BOOKComputational Toxicology

Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided

Risk Assessment for Human Metal Exposures

Risk Assessment for Human Metal Exposures
  • Author : Gunnar F. Nordberg,Bruce A. Fowler
  • Publisher : Academic Press
  • Release : 21 August 2018
GET THIS BOOKRisk Assessment for Human Metal Exposures

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA –TKTD can be used. In addition, it presents tactics on how information generated by such methods

Biomarkers in Toxicology

Biomarkers in Toxicology
  • Author : Ramesh C. Gupta
  • Publisher : Academic Press
  • Release : 13 February 2019
GET THIS BOOKBiomarkers in Toxicology

Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect

Electronic Waste

Electronic Waste
  • Author : Bruce A. Fowler
  • Publisher : Academic Press
  • Release : 13 April 2017
GET THIS BOOKElectronic Waste

Electronic Waste: Toxicology and Public Health Issues discusses the major public health concerns due to the presence of toxic chemicals that are generated from improper recycling and disposal practices of electronic waste (e-waste). This book highlights hazardous inorganic chemicals found in e-waste, including arsenic, cadmium, lead, mercury, gallium, iridium, and nanomaterials, also focusing on health issues related to the presence of BPA, styrene, and other plastic components and combustion products, while also identifying populations at special risk. To provide readers

Toxicological Risk Assessment and Multi-System Health Impacts from Exposure

Toxicological Risk Assessment and Multi-System Health Impacts from Exposure
  • Author : Aristidis M. Tsatsakis
  • Publisher : Elsevier
  • Release : 01 August 2021
GET THIS BOOKToxicological Risk Assessment and Multi-System Health Impacts from Exposure

Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into

Handbook on the Toxicology of Metals

Handbook on the Toxicology of Metals
  • Author : Gunnar F. Nordberg,Bruce A. Fowler,Monica Nordberg
  • Publisher : Academic Press
  • Release : 07 August 2014
GET THIS BOOKHandbook on the Toxicology of Metals

Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology,

Computational Toxicology

Computational Toxicology
  • Author : Hong Fang,Huixiao Hong,Zhichao Liu,Roger Perkins,Reagan Kelly,John Beresney,Weida Tong,Bruce A. Fowler
  • Publisher : Elsevier Inc. Chapters
  • Release : 04 June 2013
GET THIS BOOKComputational Toxicology

Current advances in genomics, proteomics, and metabolomics are widely anticipated to translate in the future to a constellation of benefits in human health. However, few biomarkers for risk assessment using “omics” technologies have been reported in the last decade. Nevertheless, the potential application for omics technologies is tremendous. The use of biomarker-based monitoring approaches as a tool for environmental risk assessment is often critically limited by a lack of integrated bioinformatics approaches, statistical analyses, and predictive models. In this chapter

Risk Management of Complex Inorganic Materials

Risk Management of Complex Inorganic Materials
  • Author : Violaine Verougstraete
  • Publisher : Academic Press
  • Release : 21 November 2017
GET THIS BOOKRisk Management of Complex Inorganic Materials

Risk Management of Complex Inorganic Materials: A Practical Guide facilitates the risk assessment and management of complex inorganic materials around the world by providing accessible and specific guidance on their assessment. Inorganic complex materials, such as ores and concentrates, metal containing- glasses, ceramic and inorganic pigments, alloys, and UVCBs produced during the manufacturing of metals present specificities not addressed by most guidance documents. This book explains the main characteristics of inorganic complex materials affecting their hazard and risk assessment and

Toxicology and Human Environments

Toxicology and Human Environments
  • Author : Ernest Hodgson
  • Publisher : Academic Press
  • Release : 25 January 2022
GET THIS BOOKToxicology and Human Environments

Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments.

Handbook on the Toxicology of Metals

Handbook on the Toxicology of Metals
  • Author : Monica Nordberg,Gunnar F. Nordberg,Bruce A. Fowler,Lars Friberg
  • Publisher : Elsevier
  • Release : 28 April 2011
GET THIS BOOKHandbook on the Toxicology of Metals

Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of

Toxicology and Human Environments

Toxicology and Human Environments
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 31 December 2012
GET THIS BOOKToxicology and Human Environments

Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments.

Genetic Toxicology and Cancer Risk Assessment

Genetic Toxicology and Cancer Risk Assessment
  • Author : Wai Nang Choy
  • Publisher : CRC Press
  • Release : 31 August 2001
GET THIS BOOKGenetic Toxicology and Cancer Risk Assessment

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and

Fundamentals of Toxicology

Fundamentals of Toxicology
  • Author : PK Gupta
  • Publisher : Academic Press
  • Release : 26 August 2016
GET THIS BOOKFundamentals of Toxicology

Fundamentals of Toxicology: Essential Concepts and Applications provides a crisp, easy-to-understand overview of the most important concepts, applications, and ideas needed to learn the basics of toxicology. Written by a pre-eminent toxicologist with over five decades of teaching experience, this comprehensive resource offers the hands-on knowledge needed for a strong foundation in the wide field of toxicology. Fundamentals of Toxicology includes a clear structure divided into five units to assist learning and understanding. The first unit provides extensive coverage on

Toxicity-Pathway-Based Risk Assessment

Toxicity-Pathway-Based Risk Assessment
  • Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Standing Committee on Risk Analysis Issues and Reviews
  • Publisher : National Academies Press
  • Release : 07 June 2010
GET THIS BOOKToxicity-Pathway-Based Risk Assessment

In 2007, the National Research Council envisioned a new paradigm in which biologically important perturbations in key toxicity pathways would be evaluated with new methods in molecular biology, bioinformatics, computational toxicology, and a comprehensive array of in vitro tests based primarily on human biology. Although some considered the vision too optimistic with respect to the promise of the new science, no one can deny that a revolution in toxicity testing is under way. New approaches are being developed, and data are