Molecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies

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  • Author : Juan Bueno
  • Publisher : Academic Press
  • Pages : 192 pages
  • ISBN : 0128189290
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKMolecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery
  • Author : Juan Bueno
  • Publisher : Academic Press
  • Release : 22 January 2020
GET THIS BOOKMolecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design
  • Author : Om Silakari,Pankaj Kumar Singh
  • Publisher : Academic Press
  • Release : 05 November 2020
GET THIS BOOKConcepts and Experimental Protocols of Modelling and Informatics in Drug Design

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design discusses each experimental protocol utilized in the field of bioinformatics, focusing especially on computer modeling for drug development. It helps the user in understanding the field of computer-aided molecular modeling (CAMM) by presenting solved exercises and examples. The book discusses topics such as fundamentals of molecular modeling, QSAR model generation, protein databases and how to use them to select and analyze protein structure, and pharmacophore modeling for drug targets.

Evolutionary Diversity as a Source for Anticancer Molecules

Evolutionary Diversity as a Source for Anticancer Molecules
  • Author : Akhileshwar Kumar Srivastava,Vinod Kumar Kannaujiya,Rajesh Kumar Singh,Divya Singh
  • Publisher : Academic Press
  • Release : 21 September 2020
GET THIS BOOKEvolutionary Diversity as a Source for Anticancer Molecules

Evolutionary Diversity as a Source for Anticancer Molecules discusses evolutionary diversity as source for anticancer agents derived from bacteria, algae, bryophytes, pteridophytes, and gymnosperms. The book goes over the isolation of anticancer agents and the technologyenabled screening process used to develop anticancer drugs. The book also includes discussion of the nutraceuticals and natural products derived from invertebrates that can be used as part of cancer treatment. Evolutionary Diversity as a Source for Anticancer Molecules also deals with some of the

Molecular Modeling in Drug Design

Molecular Modeling in Drug Design
  • Author : Rebecca Wade,Outi Salo-Ahen
  • Publisher : MDPI
  • Release : 26 March 2019
GET THIS BOOKMolecular Modeling in Drug Design

Since the first attempts at structure-based drug design about four decades ago, molecular modelling techniques for drug design have developed enormously, along with the increasing computational power and structural and biological information of active compounds and potential target molecules. Nowadays, molecular modeling can be considered to be an integral component of the modern drug discovery and development toolbox. Nevertheless, there are still many methodological challenges to be overcome in the application of molecular modeling approaches to drug discovery. The eight

De novo Molecular Design

De novo Molecular Design
  • Author : Gisbert Schneider
  • Publisher : Wiley-VCH
  • Release : 23 December 2013
GET THIS BOOKDe novo Molecular Design

Systematically examining current methods and strategies, this ready reference covers a wide range of molecular structures, from organic-chemical drugs to peptides, Proteins and nucleic acids, in line with emerging new drug classes derived from biomacromolecules. A leader in the field and one of the pioneers of this young discipline has assembled here the most prominent experts from across the world to provide first-hand knowledge. While most of their methods and examples come from the area of pharmaceutical discovery and development,

Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
  • Author : Benjamin E. Blass
  • Publisher : Academic Press
  • Release : 30 March 2021
GET THIS BOOKBasic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and

3D QSAR in Drug Design

3D QSAR in Drug Design
  • Author : Hugo Kubinyi,Gerd Folkers,Yvonne C. Martin
  • Publisher : Springer Science & Business Media
  • Release : 11 April 2006
GET THIS BOOK3D QSAR in Drug Design

Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships (3D QSAR) since the first publication by Richard Cramer in 1988 and the first volume in the series. 3D QSAR in Drug Design. Theory, Methods and Applications, published in 1993. The aim of that early book was to contribute to the understanding and the further application of CoMFA and related approaches and to facilitate the appropriate use of these methods. Since then, hundreds of papers have appeared using the

Adaptive Systems in Drug Design

Adaptive Systems in Drug Design
  • Author : Gisbert Schneider
  • Publisher : CRC Press
  • Release : 01 October 2002
GET THIS BOOKAdaptive Systems in Drug Design

A brief history of drug design presented to make clear that there are fashions in this important field and that they change rather rapidly. This is due in part to the fact that the way that a new paradigm is accepted in a drug company often does not depend on its scientific merit alone.

Genetic Algorithms in Molecular Modeling

Genetic Algorithms in Molecular Modeling
  • Author : James Devillers
  • Publisher : Academic Press
  • Release : 07 June 1996
GET THIS BOOKGenetic Algorithms in Molecular Modeling

Genetic Algorithms in Molecular Modeling is the first book available on the use of genetic algorithms in molecular design. This volume marks the beginning of an ew series of books, Principles in Qsar and Drug Design, which will be an indispensible reference for students and professionals involved in medicinal chemistry, pharmacology, (eco)toxicology, and agrochemistry. Each comprehensive chapter is written by a distinguished researcher in the field. Through its up to the minute content, extensive bibliography, and essential information on

Drug Design and Discovery in Alzheimer’s Disease

Drug Design and Discovery in Alzheimer’s Disease
  • Author : Atta-ur-Rahman,Muhammad Iqbal Choudhary
  • Publisher : Elsevier
  • Release : 27 June 2015
GET THIS BOOKDrug Design and Discovery in Alzheimer’s Disease

Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery.

Artificial Intelligence in Drug Discovery

Artificial Intelligence in Drug Discovery
  • Author : Nathan Brown
  • Publisher : Royal Society of Chemistry
  • Release : 11 November 2020
GET THIS BOOKArtificial Intelligence in Drug Discovery

Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and

Evolutionary Algorithms in Theory and Practice

Evolutionary Algorithms in Theory and Practice
  • Author : Thomas Bäck
  • Publisher : Oxford University Press on Demand
  • Release : 22 January 1996
GET THIS BOOKEvolutionary Algorithms in Theory and Practice

A comparison of evolutionary algorithms. Organic evolution and problem solving. Biological background. Evolutionary algorithms and artificial intelligence. Evolutionary algorithms and global optimization. Early approaches. Specific evolutionary algorithms. Evolution strategies. Evolutionary programming. Genetic algorithms. Artificial landscapes. An empirical comparison. Extending genetic algorithms. Selection. Selection mechanisms. Experimental investigation of selection. Mutation. Simplified genetic algorithms. An experiment in meta-evolution. Summary and outlook. Data for the fletcher-powell function. Data from selection experiments. Software. The multiprocessor environment; mathematical symbols.

Swarm Intelligence and Evolutionary Algorithms in Healthcare and Drug Development

Swarm Intelligence and Evolutionary Algorithms in Healthcare and Drug Development
  • Author : Sandeep Kumar,Anand Nayyar,Anand Paul
  • Publisher : CRC Press
  • Release : 05 December 2019
GET THIS BOOKSwarm Intelligence and Evolutionary Algorithms in Healthcare and Drug Development

Healthcare sector is characterized by difficulty, dynamism and variety. In 21st century, healthcare domain is surrounded by tons of challenges in terms of Disease detection, prevention, high costs, skilled technicians and better infrastructure. In order to handle these challenges, Intelligent Healthcare management technologies are required to play an effective role in improvising patient’s life. Healthcare organizations also need to continuously discover useful and actionable knowledge to gain insight from tons of data for various purposes for saving lives, reducing

Evolutionary Computation in Bioinformatics

Evolutionary Computation in Bioinformatics
  • Author : Gary B. Fogel,David W. Corne
  • Publisher : Morgan Kaufmann
  • Release : 22 January 2022
GET THIS BOOKEvolutionary Computation in Bioinformatics

This book offers a definitive resource that bridges biology and evolutionary computation. The authors have written an introduction to biology and bioinformatics for computer scientists, plus an introduction to evolutionary computation for biologists and for computer scientists unfamiliar with these techniques.

Successful Drug Discovery

Successful Drug Discovery
  • Author : János Fischer,Christian Klein,Wayne E. Childers
  • Publisher : John Wiley & Sons
  • Release : 07 October 2019
GET THIS BOOKSuccessful Drug Discovery

Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that