Monoclonal Antibodies

Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies. Discusses the challenges to develop MAbs for intravenous (IV) and subcutaneous delivery (SC) Presents strategies to meet the challenges in development of MAbs for SC and IV administration Discusses the use of biophysical analytical tools coupled with MAb engineering to understand what governs MAb properties at high concentration

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  • Author : Steven Shire
  • Publisher : Woodhead Publishing
  • Pages : 224 pages
  • ISBN : 0081002971
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKMonoclonal Antibodies

Monoclonal Antibodies

Monoclonal Antibodies
  • Author : Steven Shire
  • Publisher : Woodhead Publishing
  • Release : 24 April 2015
GET THIS BOOKMonoclonal Antibodies

Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use

Monoclonal Antibodies

Monoclonal Antibodies
  • Author : James W. Goding
  • Publisher : Unknown Publisher
  • Release : 25 May 1986
GET THIS BOOKMonoclonal Antibodies

This book represents the distillation and critical evaluation of many hundreds of publications relating to the production and use of antibodies. Therefore it is restricted to the "core" techniques of production and handling of antibodies, and their use in studies of antigen analysis, purification and localization.

Monoclonal Antibodies

Monoclonal Antibodies
  • Author : Harleen Kaur,Dietmar Reusch
  • Publisher : Elsevier
  • Release : 03 August 2021
GET THIS BOOKMonoclonal Antibodies

Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and

Drug-Induced Liver Injury

Drug-Induced Liver Injury
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 13 July 2019
GET THIS BOOKDrug-Induced Liver Injury

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic

Monoclonal Antibody Production

Monoclonal Antibody Production
  • Author : National Research Council,Institute for Laboratory Animal Research,Committee on Methods of Producing Monoclonal Antibodies
  • Publisher : National Academies Press
  • Release : 06 June 1999
GET THIS BOOKMonoclonal Antibody Production

The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The

Therapeutic Monoclonal Antibodies

Therapeutic Monoclonal Antibodies
  • Author : Zhiqiang An
  • Publisher : John Wiley & Sons
  • Release : 20 September 2011
GET THIS BOOKTherapeutic Monoclonal Antibodies

70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Monoclonal Antibodies

Monoclonal Antibodies
  • Author : Heddy Zola
  • Publisher : CRC Press
  • Release : 31 July 1987
GET THIS BOOKMonoclonal Antibodies

This book describes, in detail, tested techniques for the produc-tion and use of monoclonal antibodies. It covers those aspects of interest to all scientists working with monoclonal antibodies and presents methods in a step-by-step format for easy refer-ence. The text serves as a laboratory manual; and discusses rationale behind each method, and the choices between methods. It also provides a rational basis where several alternative methods are available.

Biosimilars of Monoclonal Antibodies

Biosimilars of Monoclonal Antibodies
  • Author : Cheng Liu,K. John Morrow, Jr.
  • Publisher : John Wiley & Sons
  • Release : 12 December 2016
GET THIS BOOKBiosimilars of Monoclonal Antibodies

Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing. • Guides readers through the complex landscape involved with developing biosimilar versions of monoclonal antibody (mAb) drugs • Features flow charts, tables, and figures that clearly illustrate processes and makes the book comprehensible and accessible • Includes a review of FDA-approved mAb drugs as a quick reference to facts and useful information •

Monoclonal Antibodies

Monoclonal Antibodies
  • Author : Roger H. Kennett
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKMonoclonal Antibodies

On August 7, 1975, Kohler and Milstein published in Nature (256:495) a report describing "Continuous cultures of fused cells secreting antibody of predefined specificity. " Their report has become a classic and has already had a profound effect on basic and applied research in biology and medicine. By the time the first Workshop on Lymphocyte Hybridomas (Current Topics in Microbiology and Im munology 81, 1978) was held on April 3-5, 1978, in Bethesda, Maryland, investi gators from many laboratories had made hybrids between plasmacytomas and spleen cells

Production and Characterization of Monoclonal Antibodies Directed Against Cell Surface Antigens of Canine Keratinocytes and Induction of Antibody-mediated Lesions in Stratified Squamous Epithelium Using Monoclonal Antibodies

Production and Characterization of Monoclonal Antibodies Directed Against Cell Surface Antigens of Canine Keratinocytes and Induction of Antibody-mediated Lesions in Stratified Squamous Epithelium Using Monoclonal Antibodies
  • Author : Maja M. Suter
  • Publisher : Unknown Publisher
  • Release : 25 May 1988
GET THIS BOOKProduction and Characterization of Monoclonal Antibodies Directed Against Cell Surface Antigens of Canine Keratinocytes and Induction of Antibody-mediated Lesions in Stratified Squamous Epithelium Using Monoclonal Antibodies