Natural Hosts of SIV

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant. Summarizes the past 30 years of research in this field and describes the latest developments in AIDS research using nonhuman primate animal models Provides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIV Highlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection

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  • Author : Aftab A. Ansari
  • Publisher : Elsevier Science Limited
  • Pages : 385 pages
  • ISBN : 9780124047341
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKNatural Hosts of SIV

Natural Hosts of SIV

Natural Hosts of SIV
  • Author : Aftab A. Ansari,Guido Silvestri
  • Publisher : Elsevier Science Limited
  • Release : 10 July 2014
GET THIS BOOKNatural Hosts of SIV

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural

Natural Hosts of SIV

Natural Hosts of SIV
  • Author : Aftab A. Ansari,Guido Silvestri
  • Publisher : Newnes
  • Release : 04 July 2014
GET THIS BOOKNatural Hosts of SIV

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural

Experimentally-induced Immune Activation in Natural Hosts of SIV Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion

Experimentally-induced Immune Activation in Natural Hosts of SIV Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion
  • Author : Anonim
  • Publisher : Unknown Publisher
  • Release : 23 September 2021
GET THIS BOOKExperimentally-induced Immune Activation in Natural Hosts of SIV Induces Significant Increases in Viral Replication and CD4+ T Cell Depletion

Chronically SIVagm-infected African green monkeys (AGMs) have a remarkably stable non-pathogenic disease course, with levels of immune activation in chronic SIVagm infection similar to those observed in uninfected monkeys and stable viral loads (VLs) for long periods of time. In vivo administration of lipopolysaccharide (LPS) or an IL-2/diphtheria toxin fusion protein (Ontak) to chronically SIVagm-infected AGMs triggered increases in immune activation and subsequently of viral replication and depletion of intestinal CD4 T cells. Our study indicates that circulating microbial

Occupational Health and Safety in the Care and Use of Nonhuman Primates

Occupational Health and Safety in the Care and Use of Nonhuman Primates
  • Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Occupational Health and Safety in the Care and Use of Nonhuman Primates
  • Publisher : National Academies Press
  • Release : 13 July 2003
GET THIS BOOKOccupational Health and Safety in the Care and Use of Nonhuman Primates

The field of occupational health and safety constantly changes, especially as it pertains to biomedical research. New infectious hazards are of particular importance at nonhuman-primate facilities. For example, the discovery that B virus can be transmitted via a splash on a mucous membrane raises new concerns that must be addressed, as does the discovery of the Reston strain of Ebola virus in import quarantine facilities in the U.S. The risk of such infectious hazards is best managed through a

AIDS Pathogenesis

AIDS Pathogenesis
  • Author : H. Schuitemaker,Frank Miedema
  • Publisher : Springer Science & Business Media
  • Release : 31 March 2000
GET THIS BOOKAIDS Pathogenesis

Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary

The Origins of AIDS

The Origins of AIDS
  • Author : Jacques Pépin
  • Publisher : Cambridge University Press
  • Release : 21 January 2021
GET THIS BOOKThe Origins of AIDS

An updated edition of Jacques Pépin's acclaimed account of the events that transformed a chimpanzee virus into a global pandemic.

Wildlife Disease Ecology

Wildlife Disease Ecology
  • Author : Kenneth Wilson,Andy Fenton,Dan Tompkins
  • Publisher : Cambridge University Press
  • Release : 30 November 2019
GET THIS BOOKWildlife Disease Ecology

Introduces readers to key case studies that illustrate how theory and data can be integrated to understand wildlife disease ecology.

Models of Protection Against HIV/SIV

Models of Protection Against HIV/SIV
  • Author : Gianfranco Pancino,Guido Silvestri,Keith R. Fowke
  • Publisher : Academic Press
  • Release : 01 January 2012
GET THIS BOOKModels of Protection Against HIV/SIV

A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature

Xenotransplantation

Xenotransplantation
  • Author : Institute of Medicine,Committee on Xenograft Transplantation: Ethical Issues and Public Policy
  • Publisher : National Academies Press
  • Release : 12 July 1996
GET THIS BOOKXenotransplantation

Xenotransplantation involves the transplantation of cells, tissues, and whole organs from one species to another. Interest in animal-to-human xenotransplants has been spurred by the continuing shortage of donated human organs and by advances in knowledge concerning the biology of organ and tissue rejection. The scientific advances and promise, however, raise complex questions that must be addressed. This book considers the scientific and medical feasibility of xenotransplantation and explores the ethical and public policy issues surrounding the possibility of renewed clinical

Encyclopedia of AIDS

Encyclopedia of AIDS
  • Author : Thomas J. Hope,Douglas D. Richman,Mario Stevenson
  • Publisher : Unknown Publisher
  • Release : 23 September 2021
GET THIS BOOKEncyclopedia of AIDS

For the first time, the world's experts in HIV-AIDS have come together to publish the Encyclopedia of AIDS. The work features thousands of entries, including medical, cultural, social, and pharmacological essays.

Microbial Threats to Health

Microbial Threats to Health
  • Author : Institute of Medicine,Board on Global Health,Committee on Emerging Microbial Threats to Health in the 21st Century
  • Publisher : National Academies Press
  • Release : 25 August 2003
GET THIS BOOKMicrobial Threats to Health

Infectious diseases are a global hazard that puts every nation and every person at risk. The recent SARS outbreak is a prime example. Knowing neither geographic nor political borders, often arriving silently and lethally, microbial pathogens constitute a grave threat to the health of humans. Indeed, a majority of countries recently identified the spread of infectious disease as the greatest global problem they confront. Throughout history, humans have struggled to control both the causes and consequences of infectious diseases and

Spillover: Animal Infections and the Next Human Pandemic

Spillover: Animal Infections and the Next Human Pandemic
  • Author : David Quammen
  • Publisher : W. W. Norton & Company
  • Release : 01 October 2012
GET THIS BOOKSpillover: Animal Infections and the Next Human Pandemic

"[Mr. Quammen] is not just among our best science writers but among our best writers, period." —Dwight Garner, New York Times The next big human pandemic—the next disease cataclysm, perhaps on the scale of AIDS or the 1918 influenza—is likely to be caused by a new virus coming to humans from wildlife. Experts call such an event “spillover” and they warn us to brace ourselves. David Quammen has tracked this subject from the jungles of Central Africa, the rooftops

Foamy Viruses

Foamy Viruses
  • Author : Axel Rethwilm
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKFoamy Viruses

The aberrant replication pathway of foamy viruses distinguishes them from all other retroviruses. Many details have been accumulated over the past ten or so years. Most of the findings on foamy viruses were obtained by research on a single virus isolate previously called "human foamy virus", which appeared to be the first to be investigated on a molecular level. However, to the editor's knowledge, genuine human foamy viruses do not exist, but several trans-species transmissions of different simian foamy viruses