Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities Describes the genes implicated in autistic spectrum disorders and their function Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

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  • Author : Carlo Sala
  • Publisher : Academic Press
  • Pages : 394 pages
  • ISBN : 0128005335
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKNeuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability
  • Author : Carlo Sala,Chiara Verpelli
  • Publisher : Academic Press
  • Release : 30 April 2016
GET THIS BOOKNeuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders.

A Time for Metabolism and Hormones

A Time for Metabolism and Hormones
  • Author : Paolo Sassone-Corsi,Yves Christen
  • Publisher : Springer
  • Release : 04 April 2016
GET THIS BOOKA Time for Metabolism and Hormones

Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the

Synaptic Function

Synaptic Function
  • Author : Synaptic Function,Neurosciences Institute (New York, N.Y.)
  • Publisher : Wiley-Interscience
  • Release : 01 August 1987
GET THIS BOOKSynaptic Function

This book consists of five sections. The first section details methods for analyzing both presynaptic and postsynaptic function and emphasizes the molecular aspects of synapses. It describes ongoing studies of neurotransmitter release, voltage- sensitive ion channels, and electronic transmission at gap junctions. The second section focuses on the growing menagerie of neurotransmitters: their catagorization into chemical families, their relation to ion channels, their modulation by second messenger systems and their role in pharmacologic action. The third section considers the important

Autism Spectrum Disorder

Autism Spectrum Disorder
  • Author : Michael Fitzgerald
  • Publisher : BoD – Books on Demand
  • Release : 02 April 2015
GET THIS BOOKAutism Spectrum Disorder

This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism

Excitatory-Inhibitory Balance

Excitatory-Inhibitory Balance
  • Author : Takao K. Hensch,Michela Fagiolini
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKExcitatory-Inhibitory Balance

A new perspective on brain function depends upon an understanding of the interaction and integration of excitation and inhibition. A recent surge in research activity focused on inhibitory interneurons now makes a more balanced view possible. Technological advances such as improved imaging methods, visualized patch-clamp recording, multiplex single-cell PCR, and gene-targeted deletion or knock-in mice are some of the novel tools featured in this book. This book will provide an integrated view of neuron function, operating in a balanced regime

The Neuroscience of Autism Spectrum Disorders

The Neuroscience of Autism Spectrum Disorders
  • Author : Joseph D. Buxbaum,Patrick R. Hof
  • Publisher : Academic Press
  • Release : 01 August 2021
GET THIS BOOKThe Neuroscience of Autism Spectrum Disorders

Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the

Neural and Synaptic Defects in Autism Spectrum Disorders

Neural and Synaptic Defects in Autism Spectrum Disorders
  • Author : Hansen Wang,Laurie C. Doering
  • Publisher : Frontiers Media SA
  • Release : 07 July 2015
GET THIS BOOKNeural and Synaptic Defects in Autism Spectrum Disorders

Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of

Autism Spectrum Disorders

Autism Spectrum Disorders
  • Author : David Amaral,Daniel Geschwind,Geraldine Dawson
  • Publisher : Oxford University Press
  • Release : 01 May 2011
GET THIS BOOKAutism Spectrum Disorders

Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research. Approximately 1 in 150 children are diagnosed as autistic, so it is also an intense growth area in behavioral and educational treatments. Financial resources have begun to be raised for more comprehensive research and an increasing number of scientists are becoming involved in autism research. In many respects, autism has become a model for conducting translational research on a

The Fragile X-Associated Tremor Ataxia Syndrome (FXTAS)

The Fragile X-Associated Tremor Ataxia Syndrome (FXTAS)
  • Author : Flora Tassone,Elizabeth M. Berry-Kravis
  • Publisher : Springer Science & Business Media
  • Release : 02 June 2010
GET THIS BOOKThe Fragile X-Associated Tremor Ataxia Syndrome (FXTAS)

In Fragile X-Associated Tremor Ataxia Syndrome (FXTAS), the editors present information on all aspects of FXTAS, including clinical features and current supportive management, radiological, psychological, and pathological findings, genotype-phenotype relationships, animal models and basic molecular mechanisms. Genetic counseling issues are also discussed. The book should serve as a resource for professionals in all fields regarding diagnosis, management, and counseling of patients with FXTAS and their families, as well as presenting the molecular basis for disease that may lead to the

Autism

Autism
  • Author : Michael Fitzgerald,Jane Yip
  • Publisher : BoD – Books on Demand
  • Release : 12 April 2017
GET THIS BOOKAutism

This book opens with a discussion of neurodiversity and an elaboration of the diagnosis of autism. It then examines factors correlating with autism, including sex bias, month of birth, migration and impact of infant feeding. The next section is on the impact of autism. The neurobiology and genetic section deals with epigenetics and intracellular pathways associated with etiology. The development and behaviour section deals with proprioceptive profiles and joint attention in autism. The final section focuses on interventions including mindfulness,

Autism Spectrum Disorders: From Genotypes to Phenotypes

Autism Spectrum Disorders: From Genotypes to Phenotypes
  • Author : Valsamma Eapen,Andrew J. Whitehouse,Charles Claudianos,Rudi Crncec
  • Publisher : Frontiers Media SA
  • Release : 10 December 2015
GET THIS BOOKAutism Spectrum Disorders: From Genotypes to Phenotypes

This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between key "social brain" regions. These interconnected neural systems can be understood through the relationship between functionally relevant anatomic areas and neurochemical pathways, the programming of which are genetically modulated during

Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies
  • Author : Jeffrey Noebels,Massimo Avoli,Michael Rogawski,Richard Olsen,Antonio Delgado-Escueta
  • Publisher : Oxford University Press
  • Release : 01 June 2012
GET THIS BOOKJasper's Basic Mechanisms of the Epilepsies

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these

ADHD

ADHD
  • Author : Jill M. Norvilitis
  • Publisher : BoD – Books on Demand
  • Release : 24 September 2015
GET THIS BOOKADHD

With many children and adults affected by Attention Deficit Hyperactivity Disorder, researchers strive to improve our understanding of the causes, consequences, and treatment of the disorder. This volume examines some of the broad arrays of research in the field of ADHD, from etiology to cutting-edge interventions. The 16 chapters explore topics ranging from comorbidity to advances in the search for biomarkers; to executive, cognitive, and social functioning; to the use of new and alternative therapies. Both the professional and the casual

New treatment perspectives in autism spectrum disorders

New treatment perspectives in autism spectrum disorders
  • Author : Roberto Canitano,Yuri Bozzi
  • Publisher : Frontiers Media SA
  • Release : 17 April 2015
GET THIS BOOKNew treatment perspectives in autism spectrum disorders

Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across