Neuronal Chloride Transporters in Health and Disease

In the past several years, there has been an exciting body of new research that links impairments in the expression or function of neuronal chloride transporters to a growing number of diseases spanning from autism to brain aging. This book introduces the core concepts and highlights the recent advances in understanding the physiology and pathophysiology of the KCC and NKCC families of neuronal chloride transporters. Neuronal chloride transporter biology is reviewed, including roles in setting the transmembrane chloride gradient and the chloride transport-independent functions, such as regulating excitatory neurotransmission. Chapters are also dedicated to addressing the structure, post-translational modification, membrane trafficking, and protein interaction partners of neuronal chloride transporters, as well as the genetic and environmental factors that regulate their expression in neurons and the novel therapeutic approaches that target neuronal chloride transporters to treat neurological diseases. This new volume will provide readers with an up-to-date summary of the recent advances in neuronal chloride transporter research, with particular emphasis on some of the key emerging topics in the field. Summarizes roles of KCCs and NKCCs in regulating inhibitory and excitatory neurotransmission Reviews the molecular and cellular biology of neuronal chloride transporters Links neuronal chloride transporter deficiencies to autism, epilepsy, depression, and more Identifies role of transporter deficiencies in pain as well as brain and spinal cord injury Discusses drug research targeting neuronal chloride transporters for nervous system diseases

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  • Author : Xin Tang
  • Publisher : Academic Press
  • Pages : 766 pages
  • ISBN : 0128153199
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKNeuronal Chloride Transporters in Health and Disease

Neuronal Chloride Transporters in Health and Disease

Neuronal Chloride Transporters in Health and Disease
  • Author : Xin Tang
  • Publisher : Academic Press
  • Release : 19 June 2020
GET THIS BOOKNeuronal Chloride Transporters in Health and Disease

In the past several years, there has been an exciting body of new research that links impairments in the expression or function of neuronal chloride transporters to a growing number of diseases spanning from autism to brain aging. This book introduces the core concepts and highlights the recent advances in understanding the physiology and pathophysiology of the KCC and NKCC families of neuronal chloride transporters. Neuronal chloride transporter biology is reviewed, including roles in setting the transmembrane chloride gradient and

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
  • Author : F. Javier Alvarez-Leefmans,Eric Delpire
  • Publisher : Academic Press
  • Release : 22 August 2009
GET THIS BOOKPhysiology and Pathology of Chloride Transporters and Channels in the Nervous System

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change

Ion Channels in Health and Disease

Ion Channels in Health and Disease
  • Author : Geoffrey S. Pitt
  • Publisher : Academic Press
  • Release : 04 October 2016
GET THIS BOOKIon Channels in Health and Disease

Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner,

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The Blood-Brain Barrier in Health and Disease, Volume One
  • Author : Katerina Dorovini-Zis
  • Publisher : CRC Press
  • Release : 23 June 2015
GET THIS BOOKThe Blood-Brain Barrier in Health and Disease, Volume One

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Over the last 25 years, we have witnessed remarkable expansion of our knowledge of the structure, biology, and function of the cerebral endothelium. In The Blood-Brain Barrier in

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  • Author : Egidio D'Angelo,Elisa Galliano,Chris I De Zeeuw
  • Publisher : Frontiers Media SA
  • Release : 29 April 2016
GET THIS BOOKThe olivo-cerebellar system

During the last decades, investigations on the olivo-cerebellar system have attained a high level of sophistication, which led to redefinitions of several structural and functional properties of neurons, synapses, connections and circuits. Research has expanded and deepened in so many directions and so many theories and models have been proposed that an ensemble review of the matter is now needed. Yet, hot topics remain open and scientific discussion is very lively at several fronts. One major question, here as well

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  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release : 05 July 2011
GET THIS BOOKGlutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting

Magnesium in the Central Nervous System

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  • Author : Robert Vink,Mihai Nechifor
  • Publisher : University of Adelaide Press
  • Release : 04 July 2022
GET THIS BOOKMagnesium in the Central Nervous System

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the

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  • Author : Janko Samardzic
  • Publisher : BoD – Books on Demand
  • Release : 21 March 2018
GET THIS BOOKGABA And Glutamate

This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission,

Role of the Choroid Plexus in Health and Disease

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  • Author : Jeppe Praetorius,Bonnie Blazer-Yost,Helle Damkier
  • Publisher : Springer Nature
  • Release : 17 April 2020
GET THIS BOOKRole of the Choroid Plexus in Health and Disease

This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. Chapter topics range from the production of CSF by electrolyte regulation in