Nitric Oxide Donors

Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. Provides background information about biology and chemistry of nitric oxide Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity Discusses the future of nitric oxide donors and their FDA approval

Produk Detail:

  • Author : Amedea Seabra
  • Publisher : Academic Press
  • Pages : 364 pages
  • ISBN : 0128134593
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKNitric Oxide Donors

Nitric Oxide Donors

Nitric Oxide Donors
  • Author : Amedea Seabra
  • Publisher : Academic Press
  • Release : 17 March 2017
GET THIS BOOKNitric Oxide Donors

Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties;

Nitric Oxide Donors

Nitric Oxide Donors
  • Author : Peng George Wang,Tingwei Bill Cai,Naoyuki Taniguchi
  • Publisher : John Wiley & Sons
  • Release : 16 August 2005
GET THIS BOOKNitric Oxide Donors

Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further

Synthesis of Novel Nitric Oxide Donors and Prodrugs of 5-fluorouracil

Synthesis of Novel Nitric Oxide Donors and Prodrugs of 5-fluorouracil
  • Author : Tingwei Cai
  • Publisher : Unknown Publisher
  • Release : 21 June 2021
GET THIS BOOKSynthesis of Novel Nitric Oxide Donors and Prodrugs of 5-fluorouracil

Abstract: This dissertation describes my Ph. D. work that focused on the synthesis and evaluation of novel nitric oxide donors, and the synthesis of derivatives of 5-fluorouracil. In chapter 1, a series of alkyl and aryl N-hydroxyguanidines were synthesized and demonstrated to act as substrates of nitric oxide synthases (NOS). The discovery of these non-amino acid hydroxyguanidines as novel substrates also led to the discovery of a novel-binding mode of NOS. In chapter 2, in order to achieve site specific delivery of

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders
  • Author : Lucia Morbidelli,Benjamin Bonavida
  • Publisher : Academic Press
  • Release : 09 February 2019
GET THIS BOOKTherapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various

Nitric Oxide and the Cell

Nitric Oxide and the Cell
  • Author : S. Moncada,G. Nisticò,G. Bagetta,E. A. Higgs
  • Publisher : Princeton University Press
  • Release : 14 March 2017
GET THIS BOOKNitric Oxide and the Cell

Nitric oxide has proven to be a molecule with wide biological significance. It is involved in myriad actions which range from physiology to pathophysiology. One of the fundamental questions in relation to its biological relevance concerns the paradoxical nature of some of its actions. For example, there is a whole range of effects related to cytoprotection, cell proliferation, differentiation, and cell death. The way in which nitric oxide becomes involved in pathophysiology is slowly being elucidated. This volume contains a

Recent Advances Towards Improved Phytoremediation of Heavy Metal Pollution

Recent Advances Towards Improved Phytoremediation of Heavy Metal Pollution
  • Author : David W.M. Leung
  • Publisher : Bentham Science Publishers
  • Release : 08 November 2013
GET THIS BOOKRecent Advances Towards Improved Phytoremediation of Heavy Metal Pollution

Heavy metal pollution represents a global challenge to both public health and environmental sustainability. Any means to reduce heavy metal pollution in the environment is of considerable economic significance. The use of green plants to clean up heavy metal pollution is an environmentally friendly as well as a low-cost approach to the problem. This plant-based biotechnology is commonly known as ‘phytoremediation’. Presently, there is limited application of this technology because useful plants with enhanced heavy metal resistance/tolerance are still

Nitric Oxide and Nitric Oxide Donors

Nitric Oxide and Nitric Oxide Donors
  • Author : Wendy Ho Yee Cheng
  • Publisher : Unknown Publisher
  • Release : 21 June 2021
GET THIS BOOKNitric Oxide and Nitric Oxide Donors

Nitric oxide (NO) may modulate mitochondrial O2 consumption in the heart, and provide another level of respiratory control under normal or hypoxic conditions. NO and NO donors have also been proposed to have both beneficial and deleterious effects during ischaemia-reperfusion (IR) injury, and both of these maybe mediated by interactions of NO with mitochondria. The aims of the research in this thesis were to investigate (i) whether there is a specific form of mitochondrial nitric oxide synthase (NOS), (ii) which