NMR Metabolomics in Cancer Research

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

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  • Author : Miroslava Čuperlović-Culf
  • Publisher : Elsevier
  • Pages : 446 pages
  • ISBN : 1908818263
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKNMR Metabolomics in Cancer Research

NMR Metabolomics in Cancer Research

NMR Metabolomics in Cancer Research
  • Author : Miroslava Čuperlović-Culf
  • Publisher : Elsevier
  • Release : 17 December 2012
GET THIS BOOKNMR Metabolomics in Cancer Research

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics

Cancer Metabolomics

Cancer Metabolomics
  • Author : Shen Hu
  • Publisher : Springer Nature
  • Release : 03 May 2021
GET THIS BOOKCancer Metabolomics

Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling

NMR-Based Metabolomics

NMR-Based Metabolomics
  • Author : G. A. Nagana Gowda,Daniel Raftery
  • Publisher : Humana
  • Release : 29 August 2020
GET THIS BOOKNMR-Based Metabolomics

This book provides broad coverage of nuclear magnetic resonance (NMR) spectroscopy-based methods and applications for the analysis of metabolites in a wide range of biological samples, from biofluids, cells, animal models, human, to plants and foods. The applications range from mechanistic understanding, biomarker discovery, environmental studies, and drug discovery to nutrition, while NMR methods include global, targeted, and isotope tracer-based techniques. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of

Lung Cancer

Lung Cancer
  • Author : Alba Fabiola Costa Torres
  • Publisher : BoD – Books on Demand
  • Release : 31 October 2018
GET THIS BOOKLung Cancer

Among the deadliest type of cancers, lung cancer faces several challenges in diagnosis and treatment: late diagnosis and misdiagnosis, inadequate tumor sampling, and resistance development to current therapies, among others. Together with advances in the understanding of molecular features, factors, and mechanisms involved in initiation and tumor progression, important improvements have occurred in diagnostics and therapeutics in the shape of advances in molecular genotyping, procedures for sampling, new potential, and less invasive sources of samples for the diagnosis and development

NMR-based Metabolomics

NMR-based Metabolomics
  • Author : Hector C Keun
  • Publisher : Royal Society of Chemistry
  • Release : 17 January 2018
GET THIS BOOKNMR-based Metabolomics

This book describes the state of the art in the application of NMR spectroscopy to metabolomics and will be a key title for researchers and practitioners.

Colon Cancer Diagnosis and Therapy

Colon Cancer Diagnosis and Therapy
  • Author : Ganji Purnachandra Nagaraju,Dhananjay Shukla,Naveen Kumar Vishvakarma
  • Publisher : Springer Nature
  • Release : 01 July 2022
GET THIS BOOKColon Cancer Diagnosis and Therapy

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the

Methodologies for Metabolomics

Methodologies for Metabolomics
  • Author : Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers
  • Publisher : Cambridge University Press
  • Release : 21 January 2013
GET THIS BOOKMethodologies for Metabolomics

Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites,

Metabolomics: From Fundamentals to Clinical Applications

Metabolomics: From Fundamentals to Clinical Applications
  • Author : Alessandra Sussulini
  • Publisher : Springer
  • Release : 28 January 2017
GET THIS BOOKMetabolomics: From Fundamentals to Clinical Applications

This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will

Proteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery
  • Author : Haleem J. Issaq,Timothy D. Veenstra
  • Publisher : Academic Press
  • Release : 24 October 2019
GET THIS BOOKProteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques

Tumor Microenvironment

Tumor Microenvironment
  • Author : Jacinta Serpa
  • Publisher : Springer Nature
  • Release : 04 March 2020
GET THIS BOOKTumor Microenvironment

The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases

The Heterogeneity of Cancer Metabolism

The Heterogeneity of Cancer Metabolism
  • Author : Anne Le
  • Publisher : Springer
  • Release : 26 June 2018
GET THIS BOOKThe Heterogeneity of Cancer Metabolism

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the

Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach

Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach
  • Author : Kakoli Bose,Pradip Chaudhari
  • Publisher : Springer Nature
  • Release : 25 November 2019
GET THIS BOOKUnravelling Cancer Signaling Pathways: A Multidisciplinary Approach

Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of

Prostate Cancer

Prostate Cancer
  • Author : Zoran Culig
  • Publisher : Humana Press
  • Release : 22 May 2018
GET THIS BOOKProstate Cancer

This volume presents methods and protocols on modern analysis of steroid receptor and prostate cancer function. Chapters detail androgen, androgen receptor action, anti-androgen enzalutamide, in vitro and in vivo models, imaging, gene fusions, and help facilitate studies with novel drugs including anti-androgens and chemotherapeutics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding

The Handbook of Metabonomics and Metabolomics

The Handbook of Metabonomics and Metabolomics
  • Author : John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
  • Publisher : Elsevier
  • Release : 11 August 2011
GET THIS BOOKThe Handbook of Metabonomics and Metabolomics

Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing