Nonclinical Assessment of Abuse Potential for New Pharmaceuticals

Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy

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  • Author : Carrie Markgraf
  • Publisher : Academic Press
  • Pages : 320 pages
  • ISBN : 0124202160
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKNonclinical Assessment of Abuse Potential for New Pharmaceuticals

Nonclinical Assessment of Abuse Potential for New Pharmaceuticals

Nonclinical Assessment of Abuse Potential for New Pharmaceuticals
  • Author : Carrie Markgraf,Thomas Hudzik,David Compton
  • Publisher : Academic Press
  • Release : 14 July 2015
GET THIS BOOKNonclinical Assessment of Abuse Potential for New Pharmaceuticals

Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol

Stem Cells in Toxicology and Medicine

Stem Cells in Toxicology and Medicine
  • Author : Saura C. Sahu
  • Publisher : John Wiley & Sons
  • Release : 13 October 2016
GET THIS BOOKStem Cells in Toxicology and Medicine

A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government

Assessment of Substance Abuse

Assessment of Substance Abuse
  • Author : Linda L. Murphy,James C. Impara
  • Publisher : Buros Desk Reference
  • Release : 17 May 1996
GET THIS BOOKAssessment of Substance Abuse

The Buros Desk Reference series contains reviews of test instruments commonly used in particular areas. Assessment of Substance Abuse is an indispensable resource for counselors, psychologists, researchers, and others who work with substance abuse issues. Reviews and descriptive information are provided for almost seventy commercially available instruments used in the identification and treatment of substance abuse and related problems. These reviews are taken from the ninth, tenth, eleventh, twelfth, and thirteenth editions of the Mental Measurements Yearbook and represent virtually

Methods of Assessing the Reinforcing Properties of Abused Drugs

Methods of Assessing the Reinforcing Properties of Abused Drugs
  • Author : Michael A. Bozarth
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKMethods of Assessing the Reinforcing Properties of Abused Drugs

Methods of Assessing the Reinforcing Properties of Abused Drugs presents a synopsis of the preclinical procedures used to assess drug reinforcement. Researchers using one technique are provided with an overview of the other available methods, and clinicians who wish to evaluate drug abuse research reports can gain the necessary background from this volume. Although emphasis is placed on the methodological aspects of assessing drug reinforcement, some of the scientific conclusions derived from using these techniques are also presented. This edited

Evaluation of Drug Candidates for Preclinical Development

Evaluation of Drug Candidates for Preclinical Development
  • Author : Chao Han,Charles B. Davis,Binghe Wang
  • Publisher : John Wiley & Sons
  • Release : 06 January 2010
GET THIS BOOKEvaluation of Drug Candidates for Preclinical Development

Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a

Pathways of Addiction

Pathways of Addiction
  • Author : Institute of Medicine,Committee on Opportunities in Drug Abuse Research
  • Publisher : National Academies Press
  • Release : 01 November 1996
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Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
  • Author : Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer
  • Publisher : Academic Press
  • Release : 13 March 2015
GET THIS BOOKThe Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity

New Treatments for Addiction

New Treatments for Addiction
  • Author : National Research Council,Institute of Medicine,Board on Neuroscience and Behavioral Health,Board on Health Promotion and Disease Prevention,Division of Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Immunotherapies and Sustained-Release Formulations for Treating Drug Addiction
  • Publisher : National Academies Press
  • Release : 03 June 2004
GET THIS BOOKNew Treatments for Addiction

New and improved therapies to treat and protect against drug dependence and abuse are urgently needed. In the United States alone about 50 million people regularly smoke tobacco and another 5 million are addicted to other drugs. In a given year, millions of these individuals attemptâ€"with or without medical assistanceâ€"to quit using drugs, though relapse remains the norm. Furthermore, each year several million teenagers start smoking and nearly as many take illicit drugs for the first time. Research is advancing

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

A Comprehensive Guide to Toxicology in Nonclinical Drug Development
  • Author : Ali S. Faqi
  • Publisher : Academic Press
  • Release : 03 November 2016
GET THIS BOOKA Comprehensive Guide to Toxicology in Nonclinical Drug Development

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of

Health and Academic Achievement

Health and Academic Achievement
  • Author : Blandina Bernal-Morales
  • Publisher : BoD – Books on Demand
  • Release : 19 September 2018
GET THIS BOOKHealth and Academic Achievement

Emotional, physical and social well-being describe human health from birth. Good health goes hand in hand with the ability to handle stress for the future. However, biological factors such as diet, life experiences such as drug abuse, bullying, burnout and social factors such as family and community support at the school stage tend to mold health problems, affecting academic achievements. This book is a compilation of current scientific information about the challenges that students, families and teachers face regarding health

Pharmacology and Therapeutics

Pharmacology and Therapeutics
  • Author : Sivakumar Joghi Thatha Gowder
  • Publisher : BoD – Books on Demand
  • Release : 02 July 2014
GET THIS BOOKPharmacology and Therapeutics

The book "Pharmacology and Therapeutics" targets every aspect of the mechanisms for the chemical actions of both traditional and novel drugs. This book covers six sections: Molecular Modeling and Bio-molecular Pharmacology, Immunopharmacology, Environmental Pharmacology and Toxicology, Nanotechnology and Chemotherapy, Drugs and Drug Delivery System and Addiction Pharmacology. Each of these sections is interwoven with the theoretical aspects and experimental techniques of physiology, biochemistry, nutrition, cellular and molecular biology, microbiology, immunology, genetics, and pathology. This book will be a significant source