Novel Sensitizing Agents for Therapeutic Anti EGFR Antibodies

Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies presents an in-depth description of sensitizers to overcome resistance to anti-EGFR targeted antibody therapies in cancer, including novel engineered antibody drugs or other sensitizers. It gives an insight into the landscape of anti-EGFR based cancer treatment, the challenges of targeted therapy, and a glimpse into the future of antibody therapy. The book offers pertinent basic science information on strategies used for the rational design and discovery of novel sensitizing agents, and, in addition, translational studies involving pre-clinical and clinical design and execution with these novel agents. It covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on EGFR blockage resistance, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new anticancer sensitizers for anti-EGFR drug resistance. This book is an indispensable resource for cancer researchers, medicinal chemists, and other biomedical scientists involved in the development of new therapeutic agents to overcome resistance to anti-EGFR treatments. Presents detailed description of history, chemistry, mechanism of action, structure-function relationships, pharmacology, side effects, dosing, and formulation of new sensitizers to anti-EGFR antibodies Provides molecular structures for all novel anticancer drugs and strategies to overcome resistance of anti-EGFR antibodies Encompasses up-to-date information on the cancer drug discovery process, including new research tools, tumor-targeting strategies, and fundamental concepts in the emerging areas of precision medicine

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  • Author : Shi Hu
  • Publisher : Academic Press
  • Pages : 300 pages
  • ISBN : 9780128215845
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKNovel Sensitizing Agents for Therapeutic Anti EGFR Antibodies

Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies

Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies
  • Author : Shi Hu
  • Publisher : Academic Press
  • Release : 15 March 2021
GET THIS BOOKNovel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies

Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies presents an in-depth description of sensitizers to overcome resistance to anti-EGFR targeted antibody therapies in cancer, including novel engineered antibody drugs or other sensitizers. It gives an insight into the landscape of anti-EGFR based cancer treatment, the challenges of targeted therapy, and a glimpse into the future of antibody therapy. The book offers pertinent basic science information on strategies used for the rational design and discovery of novel sensitizing agents, and, in addition,

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 21 November 2018
GET THIS BOOKProtein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic,

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy
  • Author : Dong-hua Yang
  • Publisher : Cancer Sensitizing Agents for
  • Release : 15 November 2018
GET THIS BOOKProtein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, Volume Four in the Cancer Sensitizing Agents for Chemotherapy Series focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and

Resistance to Immunotherapeutic Antibodies in Cancer

Resistance to Immunotherapeutic Antibodies in Cancer
  • Author : Benjamin Bonavida
  • Publisher : Springer Science & Business Media
  • Release : 04 August 2013
GET THIS BOOKResistance to Immunotherapeutic Antibodies in Cancer

​​​​The traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic. There have been encouraging results in alternative therapeutic approach called antibody-mediated anti-cancer therapy, which is less toxic, more selective, and can also reverse drug/radiation resistance. Monoclonal antibodies or mAbs can be used to destroy malignant tumor cells and prevent tumor growth by blocking specific cell receptors. mAbs can

Novel Therapies in Head and Neck Cancer: Beyond the Horizon

Novel Therapies in Head and Neck Cancer: Beyond the Horizon
  • Author : Maie A. St. John,No hee Park
  • Publisher : Academic Press
  • Release : 29 June 2020
GET THIS BOOKNovel Therapies in Head and Neck Cancer: Beyond the Horizon

Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine

Handbook of Cancer Treatment-Related Symptoms and Toxicities E-Book

Handbook of Cancer Treatment-Related Symptoms and Toxicities E-Book
  • Author : Vamsidhar Velcheti,Salman R Punekar
  • Publisher : Elsevier Health Sciences
  • Release : 28 January 2021
GET THIS BOOKHandbook of Cancer Treatment-Related Symptoms and Toxicities E-Book

Early recognition and management of adverse effects of cancer treatments are essential for optimal care of patients with cancer, and drastically different approaches are required for different physiologic reactions. Handbook of Cancer Treatment-Related Symptoms and Toxicities is a focused, one-stop resource that enables clinicians to quickly find up-to-date, reliable information needed at the point of care. The high-yield approach prioritizes the most common toxicities associated with cancer treatment, and concise, templated chapters offer fast access to information needed in day-to-day

Novel Anticancer Agents

Novel Anticancer Agents
  • Author : Alex A. Adjei,John K. Buolamwini
  • Publisher : Academic Press
  • Release : 28 April 2011
GET THIS BOOKNovel Anticancer Agents

This book offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic

Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy

Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy
  • Author : Benjamin Bonavida
  • Publisher : Springer Science & Business Media
  • Release : 31 July 2008
GET THIS BOOKSensitization of Cancer Cells for Chemo/Immuno/Radio-therapy

This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile studies on tumor cell sensitization. It will prove useful for students, scientists, clinicians and pharmaceutical companies.

Clinical Radiation Oncology E-Book

Clinical Radiation Oncology E-Book
  • Author : Leonard L. Gunderson,Joel E. Tepper
  • Publisher : Elsevier Health Sciences
  • Release : 16 June 2015
GET THIS BOOKClinical Radiation Oncology E-Book

Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team. Content

Topics on Cervical Cancer With an Advocacy for Prevention

Topics on Cervical Cancer With an Advocacy for Prevention
  • Author : Rajamanickam Rajkumar
  • Publisher : BoD – Books on Demand
  • Release : 02 March 2012
GET THIS BOOKTopics on Cervical Cancer With an Advocacy for Prevention

Cervical Cancer is one of the leading cancers among women, especially in developing countries. Prevention and control are the most important public health strategies. Empowerment of women, education, "earlier" screening by affordable technologies like visual inspection, and treatment of precancers by cryotherapy/ LEEP are the most promising interventions to reduce the burden of cervical cancer.Dr Rajamanickam Rajkumar had the privilege of establishing a rural population based cancer registry in South India in 1996, as well as planning and implementing a

Radiation Oncology E-Book

Radiation Oncology E-Book
  • Author : James D. Cox,Kie Kian Ang
  • Publisher : Elsevier Health Sciences
  • Release : 29 October 2009
GET THIS BOOKRadiation Oncology E-Book

Radiation Oncology: Rationale, Technique, Results, by James D. Cox, MD and K. Kian Ang, MD, PhD, provides you with authoritative guidance on the latest methods for using radiotherapy to treat patients with cancer. Progressing from fundamental principles through specific treatment strategies for the cancers of each organ system, it also addresses the effects of radiation on normal structures and the avoidance of complications. This 9th edition covers the most recent indications and techniques in the field, including new developments in

Immune Regulation

Immune Regulation
  • Author : Marc Feldmann,N. A. Mitchison
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKImmune Regulation

Leukocyte culture conferences have a long pedigree. This volume records some of the scientific highlights of the 16th such annual con ference, and is a witness to the continuing evolution and popularity of leukocyte culture and of immunology. There is strong evidence of the widening horizons of immunology, both technically, with the obviously major impact of molecular biology into our understanding of cellular processes, and also conceptually. Traditionally, the 'proceedings' of these conferences have been published. But have the books

Is the Recent Burst of Therapeutic Anti-Tumor Antibodies the Tip of an Iceberg?

Is the Recent Burst of Therapeutic Anti-Tumor Antibodies the Tip of an Iceberg?
  • Author : Leonor Kremer,Jose A. Garcia-Sanz
  • Publisher : Frontiers Media SA
  • Release : 27 March 2018
GET THIS BOOKIs the Recent Burst of Therapeutic Anti-Tumor Antibodies the Tip of an Iceberg?

The high effectiveness of antibodies as anti-tumor therapeutic agents has led to a burst of research aiming to increase their therapeutic applications by the use of antibodies against new targets, new antibody formats or new combinations. In this e-book we present relevant research depicting the current efforts in the field.

Safety of Biologics Therapy

Safety of Biologics Therapy
  • Author : Brian A. Baldo
  • Publisher : Springer
  • Release : 12 August 2016
GET THIS BOOKSafety of Biologics Therapy

This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 28 March 2018
GET THIS BOOKTargeting Cell Survival Pathways to Enhance Response to Chemotherapy

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have