The Oncogenomics Handbook

An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.

Produk Detail:

  • Author : William J. LaRochelle
  • Publisher : Springer Science & Business Media
  • Pages : 750 pages
  • ISBN : 1592598935
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKThe Oncogenomics Handbook

The Oncogenomics Handbook

The Oncogenomics Handbook
  • Author : William J. LaRochelle,Richard A. Shimkets
  • Publisher : Springer Science & Business Media
  • Release : 09 November 2007
GET THIS BOOKThe Oncogenomics Handbook

An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from

Oncogenomics

Oncogenomics
  • Author : Charles Brenner,David Duggan
  • Publisher : John Wiley & Sons
  • Release : 19 November 2004
GET THIS BOOKOncogenomics

This book aims to assemble the only available rigorous, yet broadly accessible introduction to this new and exciting field. Oncogenomics: Molecular Approaches to Cancer is approachable by basic scientists, practitioners, and other health professionals required to familiarize themselves with the tremendous impact of genomics and proteomics on cancer research. Clearly written chapters offer reviews of state of the art topics such as molecular classification, early detection, SNPs in cancer, data mining, tissue microarrays, protein and antibody arrays, and drug targets.

Oncogenomics

Oncogenomics
  • Author : Franco Dammacco,Franco Silvestris
  • Publisher : Academic Press
  • Release : 30 October 2018
GET THIS BOOKOncogenomics

Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists,

Oncogenomics and Cancer Proteomics

Oncogenomics and Cancer Proteomics
  • Author : Cesar Lopez-Camarillo,Elena Arechaga-Ocampo
  • Publisher : BoD – Books on Demand
  • Release : 13 March 2013
GET THIS BOOKOncogenomics and Cancer Proteomics

Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer presents comprehensive reviews of the most common cancers from bench to bedside applications by an international team of experts. This book will contribute to the scientific and medical community by providing up-to-date discoveries of oncogenomics and their potential applications in cancer translational research. It is intended for students, scientists, clinicians, oncologists and health professionals working in cancer research.

Systems and Integrative Approaches in Oncogenomics

Systems and Integrative Approaches in Oncogenomics
  • Author : Anonim
  • Publisher : Unknown Publisher
  • Release : 21 June 2021
GET THIS BOOKSystems and Integrative Approaches in Oncogenomics

Significant progress in technology has allowed systems level molecular profiling of cancer which has created a wealth of unprecedented genomics ('oncogenomics') data. Innovative and integrated approaches are needed to translate this rich information into knowledge. In this dissertation, I have explored 3 such case studies involving high throughput datasets such as RNAi screens, mutation profiling and microarrays. By generating and testing hypotheses from fusing different datasets, I have attempted to characterize genetic determinants of tumor biology and their relevance to drug

Applications of Biotechnology in Oncology

Applications of Biotechnology in Oncology
  • Author : Kewal K. Jain
  • Publisher : Springer Science & Business Media
  • Release : 19 November 2013
GET THIS BOOKApplications of Biotechnology in Oncology

Applications of Biotechnology in Oncology collects key writings by Kewal K. Jain on the most important contributions of biotechnology to cancer research, particularly to the molecular diagnosis of cancer and drug delivery in cancer for personalized management of patients. Basics of various “omics” technologies and their application in oncology are described as oncogenomics and oncoproteomics. This detailed volume also explores molecular diagnostics, nanobiotechnology, cell and gene therapies, as well as personalized oncology. With approximately one thousand selected references from recent

Advances in Biology and Therapy of Multiple Myeloma

Advances in Biology and Therapy of Multiple Myeloma
  • Author : Nikhil C. Munshi,Kenneth C. Anderson
  • Publisher : Springer Science & Business Media
  • Release : 15 November 2012
GET THIS BOOKAdvances in Biology and Therapy of Multiple Myeloma

Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM

Advances in Biology and Therapy of Multiple Myeloma

Advances in Biology and Therapy of Multiple Myeloma
  • Author : Nikhil C. Munshi,Kenneth C. Anderson
  • Publisher : Springer Science & Business Media
  • Release : 09 December 2012
GET THIS BOOKAdvances in Biology and Therapy of Multiple Myeloma

Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM

Clinical Epigenetics

Clinical Epigenetics
  • Author : Luke B. Hesson,Antonia L. Pritchard
  • Publisher : Springer Nature
  • Release : 31 August 2019
GET THIS BOOKClinical Epigenetics

In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of

Critical Issues in Head and Neck Oncology

Critical Issues in Head and Neck Oncology
  • Author : Jan B. Vermorken,Volker Budach,C. René Leemans,Jean-Pascal Machiels,Piero Nicolai,Brian O'Sullivan
  • Publisher : Springer
  • Release : 12 November 2018
GET THIS BOOKCritical Issues in Head and Neck Oncology

This book provides an overview of the latest advances in head and neck cancer using a multidisciplinary approach. Commencing with a discussion of epidemiological and diagnostic aspects, including the role of vaccination and key pathological features, the book then follows by examining the role of oncogenomics, proteomics, next generation sequencing and homologous recombination function in predicting outcomes. The topics are presented by epidemiologists, pathologists and basic scientists with further contributions from medical oncologists, head and neck cancer surgical specialists (ORL /

Translational Research and Onco-omics Applications in the Era of Cancer Personal Genomics

Translational Research and Onco-omics Applications in the Era of Cancer Personal Genomics
  • Author : Erika Ruiz-Garcia,Horacio Astudillo-de la Vega
  • Publisher : Unknown Publisher
  • Release : 21 June 2021
GET THIS BOOKTranslational Research and Onco-omics Applications in the Era of Cancer Personal Genomics

"This book presents concise chapters written by internationally respected experts on various important aspects of translational cancer genomics, offering a comprehensive overview of the onco-omics applications in the new era of cancer personal genomics research field. Being a complex disease that affects millions of people worldwide, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. In the other hand, personalized medicine in cancer