Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher : National Academies Press
  • Release : 06 February 2014
GET THIS BOOKImproving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective

Peptide-based Drug Discovery

Peptide-based Drug Discovery
  • Author : Ved Srivastava
  • Publisher : Royal Society of Chemistry
  • Release : 26 June 2017
GET THIS BOOKPeptide-based Drug Discovery

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes

Nanostructured Biomaterials for Overcoming Biological Barriers

Nanostructured Biomaterials for Overcoming Biological Barriers
  • Author : Maria Jose Alonso,Noemi S. Csaba
  • Publisher : Royal Society of Chemistry
  • Release : 21 June 2021
GET THIS BOOKNanostructured Biomaterials for Overcoming Biological Barriers

Overcoming biological barriers is of importance for solving the problems of many current drugs and vaccines, and is especially relevant in the commerical exploitation of new therapeutic strategies. This book focuses on the mechanistic issues related to the interaction between drug delivery systems and biological barriers.

Drug Discovery Targeting Drug-Resistant Bacteria

Drug Discovery Targeting Drug-Resistant Bacteria
  • Author : Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
  • Publisher : Academic Press
  • Release : 15 May 2020
GET THIS BOOKDrug Discovery Targeting Drug-Resistant Bacteria

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules

Protein Kinases in Drug Discovery

Protein Kinases in Drug Discovery
  • Author : Rossen Donev
  • Publisher : Academic Press
  • Release : 01 March 2021
GET THIS BOOKProtein Kinases in Drug Discovery

Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress,

Natural Products

Natural Products
  • Author : Lixin Zhang,Arnold L. Demain
  • Publisher : Springer Science & Business Media
  • Release : 17 November 2007
GET THIS BOOKNatural Products

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese

Drug Repositioning: Current Advances and Future Perspectives

Drug Repositioning: Current Advances and Future Perspectives
  • Author : Yuhei Nishimura,Hideaki Hara
  • Publisher : Frontiers Media SA
  • Release : 11 January 2019
GET THIS BOOKDrug Repositioning: Current Advances and Future Perspectives

Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically,

Drug Discovery and Development, Third Edition

Drug Discovery and Development, Third Edition
  • Author : James J. O'Donnell,John Somberg,Vincent Idemyor,James T. O'Donnell
  • Publisher : CRC Press
  • Release : 21 November 2019
GET THIS BOOKDrug Discovery and Development, Third Edition

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the

Transforming Clinical Research in the United States

Transforming Clinical Research in the United States
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
  • Publisher : National Academies Press
  • Release : 22 October 2010
GET THIS BOOKTransforming Clinical Research in the United States

An ideal health care system relies on efficiently generating timely, accurate evidence to deliver on its promise of diminishing the divide between clinical practice and research. There are growing indications, however, that the current health care system and the clinical research that guides medical decisions in the United States falls far short of this vision. The process of generating medical evidence through clinical trials in the United States is expensive and lengthy, includes a number of regulatory hurdles, and is

RNA Interference

RNA Interference
  • Author : Paul H. Johnson
  • Publisher : Wiley
  • Release : 15 February 2011
GET THIS BOOKRNA Interference

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.

Oral Formulation Roadmap from Early Drug Discovery to Development

Oral Formulation Roadmap from Early Drug Discovery to Development
  • Author : Elizabeth Kwong
  • Publisher : John Wiley & Sons
  • Release : 06 February 2017
GET THIS BOOKOral Formulation Roadmap from Early Drug Discovery to Development

Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development. • Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry • Focuses on pre (or non-) clinical and early stage development, the phases where most compounds are used in drug research • Features case studies to illustrate practical challenges and solutions in formulation selection •

Burger's Medicinal Chemistry and Drug Discovery, Therapeutic Agents

Burger's Medicinal Chemistry and Drug Discovery, Therapeutic Agents
  • Author : Manfred E. Wolff
  • Publisher : Wiley-Interscience
  • Release : 26 April 1996
GET THIS BOOKBurger's Medicinal Chemistry and Drug Discovery, Therapeutic Agents

The most comprehensive source of the latest information in drug discovery and medicinal chemistry BURGER'S MEDICINAL CHEMISTRY AND DRUG DISCOVERY, FIFTH EDITION, Volume 2: Therapeutic Agents Renowned for its incisive, systematic examination of the new classes of drugs, Burger's Medicinal Chemistry and Drug Discovery provides professionals with thorough, yet selective access to drug chemistry information in a convenient format. Volume 2 outlines the newest generation of drugs with the potential for controlling cardiovascular, gastrointestinal, and tubercular disease. These include: * Cholinergics and anticholinergics *