Overflow Metabolism

Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage. Includes examples of overflow metabolism and major phenomenological features Features a critical view of proposed theories to explain overflow metabolism Provides a summary of our preview work, proposing molecular crowding as the cause of overflow metabolism, together with new unpublished results

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  • Author : Alexei Vazquez
  • Publisher : Academic Press
  • Pages : 84 pages
  • ISBN : 0128123354
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKOverflow Metabolism

Overflow Metabolism

Overflow Metabolism
  • Author : Alexei Vazquez
  • Publisher : Academic Press
  • Release : 27 October 2017
GET THIS BOOKOverflow Metabolism

Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high

The Study of Overflow Metabolism and Kinetics in a Model of Metabolism and Gene Expression of Escherichia Coli

The Study of Overflow Metabolism and Kinetics in a Model of Metabolism and Gene Expression of Escherichia Coli
  • Author : Chuankai Cheng
  • Publisher : Unknown Publisher
  • Release : 22 September 2021
GET THIS BOOKThe Study of Overflow Metabolism and Kinetics in a Model of Metabolism and Gene Expression of Escherichia Coli

Overflow metabolism can be explained by a pathway switch behavior in the cell based on the tradeoffs between metabolic efficiency and proteomic efficiency (enzymatic kinetics). This thesis simulates this behavior on the both small-scale and genome-scale model. By sweeping the enzyme kinetics parameters on multiple pathways or reactions, the simulation could potentially approach the experimental results, however, would converge to some bounds beyond. Therefore, hypotheses of some extra constraints, such as the limitation of oxygen uptake, electron transport chain, as

The Exometabolome of Clostridium Thermocellum Reveals Overflow Metabolism at High Cellulose Loading

The Exometabolome of Clostridium Thermocellum Reveals Overflow Metabolism at High Cellulose Loading
  • Author : Anonim
  • Publisher : Unknown Publisher
  • Release : 22 September 2021
GET THIS BOOKThe Exometabolome of Clostridium Thermocellum Reveals Overflow Metabolism at High Cellulose Loading

Background: Clostridium thermocellum is a model thermophilic organism for the production of biofuels from lignocellulosic substrates. The majority of publications studying the physiology of this organism use substrate concentrations of ≤10 g/L. However, industrially relevant concentrations of substrate start at 100 g/L carbohydrate, which corresponds to approximately 150 g/L solids. To gain insight into the physiology of fermentation of high substrate concentrations, we studied the growth on, and utilization of high concentrations of crystalline cellulose varying from 50 to 100 g/L

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Insect-Plant Interactions
  • Author : Elizabeth A. Bernays
  • Publisher : CRC Press
  • Release : 01 October 2019
GET THIS BOOKInsect-Plant Interactions

First Published in 1989, this book explores the relationship between plants and insects and the ways in which they interact with each other. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in their respective fields.

Physiological Stress Responses in Bioprocesses

Physiological Stress Responses in Bioprocesses
  • Author : Sven-Olof Enfors,Thomas Egli
  • Publisher : Springer Science & Business Media
  • Release : 06 May 2004
GET THIS BOOKPhysiological Stress Responses in Bioprocesses

This review series covers trends in modern biotechnology. All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated. Electronic version available at http://link.springer.de/series/abe/

Basic Biotechnology

Basic Biotechnology
  • Author : Colin Ratledge,Bjorn Kristiansen
  • Publisher : Cambridge University Press
  • Release : 25 May 2006
GET THIS BOOKBasic Biotechnology

Biotechnology is one of the major technologies of the twenty-first century. Its wide-ranging, multi-disciplinary activities include recombinant DNA techniques, cloning and the application of microbiology to the production of goods from bread to antibiotics. In this new edition of the textbook Basic Biotechnology, biology and bioprocessing topics are uniquely combined to provide a complete overview of biotechnology. The fundamental principles that underpin all biotechnology are explained and a full range of examples are discussed to show how these principles are

Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production

Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production
  • Author : Kazuyuki Shimizu
  • Publisher : CRC Press
  • Release : 12 July 2017
GET THIS BOOKMetabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production

The global warming problem is becoming critical year by year, causing climate disaster all over the world, where it has been believed that the CO2 gas emitted from the factories and the burning of fossil fuels may be one of the reasons of global warming. Moreover, the global stock of fossil fuels is limited, and may run out soon within several tens of years. Although wind, geo-thermal, and tide energies have been considered as clean energy sources, those depend on

Quantitative Aspects of Growth and Metabolism of Microorganisms

Quantitative Aspects of Growth and Metabolism of Microorganisms
  • Author : A.H. Stouthamer
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKQuantitative Aspects of Growth and Metabolism of Microorganisms

Application of recent advances, such as non-equilibrium thermodynamics, the maintenance concept and the material balancing method, to the description, of microbial growth has suggested new experimental approaches which have yielded a wealth of data. These data have been used to develop mathematical models of microbial growth and metabolism, and the models have made it possible to direct the metabolism of a microorganism in such a way that more of a certain desired product is made. While a full quantitative description

Cell Culture Technology for Pharmaceutical and Cell-Based Therapies

Cell Culture Technology for Pharmaceutical and Cell-Based Therapies
  • Author : Sadettin Ozturk,Wei-Shou Hu
  • Publisher : CRC Press
  • Release : 30 August 2005
GET THIS BOOKCell Culture Technology for Pharmaceutical and Cell-Based Therapies

Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of current cell culture technology used in the pharmaceutical industry. Contributions from several leading researchers showcase the importance of gene discovery and genomic technology devel

Evolution, Development and Complexity

Evolution, Development and Complexity
  • Author : Georgi Yordanov Georgiev,John M. Smart,Claudio L. Flores Martinez,Michael E. Price
  • Publisher : Springer
  • Release : 25 June 2019
GET THIS BOOKEvolution, Development and Complexity

This book explores the universe and its subsystems from the three lenses of evolutionary (contingent), developmental (predictable), and complex (adaptive) processes at all scales. It draws from prolific experts within the academic disciplines of complexity science, physical science, information and computer science, theoretical and evo-devo biology, cosmology, astrobiology, evolutionary theory, developmental theory, and philosophy. The chapters come from a Satellite Meeting, "Evolution, Development and Complexity" (EDC) hosted at the Conference on Complex Systems, in Cancun, 2017. The contributions have been peer-reviewed

Issues in Chemical, Biological, and Medical Engineering: 2013 Edition

Issues in Chemical, Biological, and Medical Engineering: 2013 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release : 01 May 2013
GET THIS BOOKIssues in Chemical, Biological, and Medical Engineering: 2013 Edition

Issues in Chemical, Biological, and Medical Engineering: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Biosystems Engineering. The editors have built Issues in Chemical, Biological, and Medical Engineering: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biosystems Engineering in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Chemical, Biological, and Medical