Overflow Metabolism

Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage. Includes examples of overflow metabolism and major phenomenological features Features a critical view of proposed theories to explain overflow metabolism Provides a summary of our preview work, proposing molecular crowding as the cause of overflow metabolism, together with new unpublished results

Produk Detail:

  • Author : Alexei Vazquez
  • Publisher : Academic Press
  • Pages : 84 pages
  • ISBN : 0128123354
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKOverflow Metabolism

Overflow Metabolism

Overflow Metabolism
  • Author : Alexei Vazquez
  • Publisher : Academic Press
  • Release : 27 October 2017
GET THIS BOOKOverflow Metabolism

Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high

The Study of Overflow Metabolism and Kinetics in a Model of Metabolism and Gene Expression of Escherichia Coli

The Study of Overflow Metabolism and Kinetics in a Model of Metabolism and Gene Expression of Escherichia Coli
  • Author : Chuankai Cheng
  • Publisher : Unknown Publisher
  • Release : 16 June 2021
GET THIS BOOKThe Study of Overflow Metabolism and Kinetics in a Model of Metabolism and Gene Expression of Escherichia Coli

Overflow metabolism can be explained by a pathway switch behavior in the cell based on the tradeoffs between metabolic efficiency and proteomic efficiency (enzymatic kinetics). This thesis simulates this behavior on the both small-scale and genome-scale model. By sweeping the enzyme kinetics parameters on multiple pathways or reactions, the simulation could potentially approach the experimental results, however, would converge to some bounds beyond. Therefore, hypotheses of some extra constraints, such as the limitation of oxygen uptake, electron transport chain, as

The Exometabolome of Clostridium Thermocellum Reveals Overflow Metabolism at High Cellulose Loading

The Exometabolome of Clostridium Thermocellum Reveals Overflow Metabolism at High Cellulose Loading
  • Author : Anonim
  • Publisher : Unknown Publisher
  • Release : 16 June 2021
GET THIS BOOKThe Exometabolome of Clostridium Thermocellum Reveals Overflow Metabolism at High Cellulose Loading

Background: Clostridium thermocellum is a model thermophilic organism for the production of biofuels from lignocellulosic substrates. The majority of publications studying the physiology of this organism use substrate concentrations of ≤10 g/L. However, industrially relevant concentrations of substrate start at 100 g/L carbohydrate, which corresponds to approximately 150 g/L solids. To gain insight into the physiology of fermentation of high substrate concentrations, we studied the growth on, and utilization of high concentrations of crystalline cellulose varying from 50 to 100 g/L

Insect-Plant Interactions

Insect-Plant Interactions
  • Author : Elizabeth A. Bernays
  • Publisher : CRC Press
  • Release : 01 October 2019
GET THIS BOOKInsect-Plant Interactions

First Published in 1989, this book explores the relationship between plants and insects and the ways in which they interact with each other. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in their respective fields.

Biotechnology, Products of Primary Metabolism

Biotechnology, Products of Primary Metabolism
  • Author : Hans-Jürgen Rehm,Max Roehr,Gerald Reed,Alfred Pühler
  • Publisher : Wiley-Blackwell
  • Release : 16 December 1996
GET THIS BOOKBiotechnology, Products of Primary Metabolism

Biotechnology Second, Completely Revised Edition Edited by H.-J. Rehm and G. Reed in cooperation with A. Pühler and P. Stadler This fully revised and expanded Second Edition takes into account all recent developments in biotechnology. It is extraordinarily broad in scope, up-to-date, carefully structured and well-balanced. 'Biotechnology' considers both basic concepts and widely-differing industrial applications: it is a successful synthesis of theory and practice. Any scientist aiming for success in industrial microbiology, biochemistry, molecular biology and chemical engineering