Oxidative Stress and Neurodegenerative Disorders

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

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  • Author : G. Ali Qureshi
  • Publisher : Elsevier
  • Pages : 794 pages
  • ISBN : 9780080489490
  • Rating : 5/5 from 1 reviews
CLICK HERE TO GET THIS BOOKOxidative Stress and Neurodegenerative Disorders

Oxidative Stress and Neurodegenerative Disorders

Oxidative Stress and Neurodegenerative Disorders
  • Author : G. Ali Qureshi,S. Hasan Parvez
  • Publisher : Elsevier
  • Release : 22 March 2007
GET THIS BOOKOxidative Stress and Neurodegenerative Disorders

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage

Handbook of Research on Critical Examinations of Neurodegenerative Disorders

Handbook of Research on Critical Examinations of Neurodegenerative Disorders
  • Author : Uddin, Md. Sahab,Amran, Md. Shah
  • Publisher : IGI Global
  • Release : 31 July 2018
GET THIS BOOKHandbook of Research on Critical Examinations of Neurodegenerative Disorders

Neurodegeneration is a key feature of several diseases that are referred to as neurodegenerative diseases. The process of neurodegeneration is not well-understood so the diseases that stem from it have, as yet, no cures. As such, studying the effects of these disorders can provide insight into the treatment, prevention, and future opportunities and challenges in this growing field. The Handbook of Research on Critical Examinations of Neurodegenerative Disorders is a critical scholarly resource that provides an extensive explanation of various

Oxidative Stress and Redox Signalling in Parkinson’s Disease

Oxidative Stress and Redox Signalling in Parkinson’s Disease
  • Author : Rodrigo Franco,Jonathan A Doorn,Jean-Christophe Rochet
  • Publisher : Royal Society of Chemistry
  • Release : 25 July 2017
GET THIS BOOKOxidative Stress and Redox Signalling in Parkinson’s Disease

Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’

Inflammation, Aging, and Oxidative Stress

Inflammation, Aging, and Oxidative Stress
  • Author : Stephen C. Bondy,Arezoo Campbell
  • Publisher : Springer
  • Release : 14 December 2016
GET THIS BOOKInflammation, Aging, and Oxidative Stress

The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer’s disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson’s disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader:

A Master Regulator of Oxidative StressThe Transcription Factor Nrf2

A Master Regulator of Oxidative StressThe Transcription Factor Nrf2
  • Author : Jose Antonio Morales-Gonzalez,Ángel Morales-González,Eduardo Osiris Madrigal-Santillan
  • Publisher : BoD – Books on Demand
  • Release : 21 December 2016
GET THIS BOOKA Master Regulator of Oxidative StressThe Transcription Factor Nrf2

Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in

Free Radicals, Antioxidants and Diseases

Free Radicals, Antioxidants and Diseases
  • Author : Rizwan Ahmad
  • Publisher : BoD – Books on Demand
  • Release : 01 August 2018
GET THIS BOOKFree Radicals, Antioxidants and Diseases

The current book entitled Free Radicals, Antioxidants, and Diseases gives an idea of detecting free radicals in vivo by newer techniques and provides insights into the roles played by various antioxidants in combating diseases caused by oxidative stress. The chapters included in this volume showcase new investigation in this field by the research groups around the world.

Brain Aging

Brain Aging
  • Author : David R. Riddle
  • Publisher : CRC Press
  • Release : 19 April 2007
GET THIS BOOKBrain Aging

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Oxidative Stress and Dietary Antioxidants in Neurological Diseases

Oxidative Stress and Dietary Antioxidants in Neurological Diseases
  • Author : Colin R. Martin,Victor R. Preedy
  • Publisher : Academic Press
  • Release : 12 June 2020
GET THIS BOOKOxidative Stress and Dietary Antioxidants in Neurological Diseases

Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases
  • Author : Luc Montagnier,Rene Olivier,Catherine Pasquier
  • Publisher : CRC Press
  • Release : 06 October 1997
GET THIS BOOKOxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease

Pathogenesis of Neurodegenerative Disorders

Pathogenesis of Neurodegenerative Disorders
  • Author : Mark P. Mattson
  • Publisher : Springer Science & Business Media
  • Release : 19 June 2021
GET THIS BOOKPathogenesis of Neurodegenerative Disorders

As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the

Neuroinflammation and Neurodegeneration

Neuroinflammation and Neurodegeneration
  • Author : Phillip K. Peterson,Michal Toborek
  • Publisher : Springer
  • Release : 08 July 2014
GET THIS BOOKNeuroinflammation and Neurodegeneration

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the

Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta

Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta
  • Author : J. Robin Harris,Falk Fahrenholz
  • Publisher : Springer Science & Business Media
  • Release : 22 November 2006
GET THIS BOOKAlzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a

Oxidative Stress and Chronic Degenerative Diseases

Oxidative Stress and Chronic Degenerative Diseases
  • Author : Jose Antonio Morales-Gonzalez
  • Publisher : BoD – Books on Demand
  • Release : 22 May 2013
GET THIS BOOKOxidative Stress and Chronic Degenerative Diseases

This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican

Oxidative Stress, Inflammation, and Health

Oxidative Stress, Inflammation, and Health
  • Author : Young-Joon Surh
  • Publisher : CRC Press
  • Release : 24 May 2005
GET THIS BOOKOxidative Stress, Inflammation, and Health

Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-analyzing the implications of oxidative stress and inflammatory damage in the pathogenesis of human disorders such as cancer, neurodegenerative disease, and diabetes.

Free Radicals in Human Health and Disease

Free Radicals in Human Health and Disease
  • Author : Vibha Rani,Umesh Chand Singh Yadav
  • Publisher : Springer
  • Release : 14 November 2014
GET THIS BOOKFree Radicals in Human Health and Disease

The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This