PAKs RAC CDC42 p21 activated Kinases

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins. This publication will be the very first book ever published solely focused on PAK family kinases. Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight. Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book. This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect.

Produk Detail:

  • Author : Hiroshi Maruta
  • Publisher : Newnes
  • Pages : 276 pages
  • ISBN : 0124072100
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKPAKs RAC CDC42 p21 activated Kinases

PAKs, RAC/CDC42 (p21)-activated Kinases

PAKs, RAC/CDC42 (p21)-activated Kinases
  • Author : Hiroshi Maruta
  • Publisher : Newnes
  • Release : 23 January 2013
GET THIS BOOKPAKs, RAC/CDC42 (p21)-activated Kinases

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen

Regulation of Cardiac Contractility

Regulation of Cardiac Contractility
  • Author : R. John Solaro
  • Publisher : Biota Publishing
  • Release : 01 April 2011
GET THIS BOOKRegulation of Cardiac Contractility

Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics of ejection as determined from maximum pressure rise in the ventricles or arteries or from aortic flow velocities determined by echocardiography. At the cellular level, the ultimate determinant of contractility is the relative tension

The Journal of Cell Biology

The Journal of Cell Biology
  • Author : Anonim
  • Publisher : Unknown Publisher
  • Release : 21 June 2021
GET THIS BOOKThe Journal of Cell Biology

No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-

Microtubule Dynamics

Microtubule Dynamics
  • Author : Anne Straube
  • Publisher : Humana Press
  • Release : 30 April 2017
GET THIS BOOKMicrotubule Dynamics

Microtubules are at the heart of cellular self-organization, and their dynamic nature allows them to explore the intracellular space and mediate the transport of cargoes from the nucleus to the outer edges of the cell and back. In Microtubule Dynamics: Methods and Protocols, experts in the field provide an up-to-date collection of methods and approaches that are used to investigate microtubule dynamics in vitro and in cells. Beginning with the question of how to analyze microtubule dynamics, the volume continues

Conquering RAS

Conquering RAS
  • Author : Asfar Azmi
  • Publisher : Academic Press
  • Release : 11 August 2016
GET THIS BOOKConquering RAS

Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging

Leucine-Rich Repeat Kinase 2 (LRRK2)

Leucine-Rich Repeat Kinase 2 (LRRK2)
  • Author : Hardy J. Rideout
  • Publisher : Springer
  • Release : 28 March 2017
GET THIS BOOKLeucine-Rich Repeat Kinase 2 (LRRK2)

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It

Cytoskeleton and Small G Proteins

Cytoskeleton and Small G Proteins
  • Author : Ph Jeanteur
  • Publisher : Springer Science & Business Media
  • Release : 21 January 1999
GET THIS BOOKCytoskeleton and Small G Proteins

The internal structure of a cell can be affected by signals in the form of small molecules outside the cell. These changes can then alter the shape or adhesiveness of the cell. This volume centers particularly on one family of cellular proteins which transmit these signals, the Rho Ras-like GTPases, and examines their role in normal cellular processes and development. Also discussed are their roles in cancer formation and microbial pathogenesis.

Mechanism of Cellular Transformation by the GTP-binding Protein Cdc42 and Its Activator, the Guanine Nucleotide Exchange Factor, Dbl

Mechanism of Cellular Transformation by the GTP-binding Protein Cdc42 and Its Activator, the Guanine Nucleotide Exchange Factor, Dbl
  • Author : Rui Lin
  • Publisher : Unknown Publisher
  • Release : 21 June 1999
GET THIS BOOKMechanism of Cellular Transformation by the GTP-binding Protein Cdc42 and Its Activator, the Guanine Nucleotide Exchange Factor, Dbl

I also examine the corresponding mutants in Rac and Rho, and determine how each individual Rho GTPases contribute to Dbl-induced cellular transformation. I find that Cdc42, Rac and RhoA appear to mediate different aspects of Dbl transformation. Specifically, Cdc42 mediates anchorage-independent growth, Rho causes a loss of contact inhibition, and Rac stimulates the formation of lamellipodia.