PAKs RAC CDC42 p21 activated Kinases

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins. This publication will be the very first book ever published solely focused on PAK family kinases. Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight. Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book. This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect.

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  • Author : Hiroshi Maruta
  • Publisher : Newnes
  • Pages : 276 pages
  • ISBN : 0124072100
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKPAKs RAC CDC42 p21 activated Kinases

PAKs, RAC/CDC42 (p21)-activated Kinases

PAKs, RAC/CDC42 (p21)-activated Kinases
  • Author : Hiroshi Maruta
  • Publisher : Newnes
  • Release : 23 January 2013
GET THIS BOOKPAKs, RAC/CDC42 (p21)-activated Kinases

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases. This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen

Leucine-Rich Repeat Kinase 2 (LRRK2)

Leucine-Rich Repeat Kinase 2 (LRRK2)
  • Author : Hardy J. Rideout
  • Publisher : Springer
  • Release : 28 March 2017
GET THIS BOOKLeucine-Rich Repeat Kinase 2 (LRRK2)

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It

Tumor Suppressing Viruses, Genes, and Drugs

Tumor Suppressing Viruses, Genes, and Drugs
  • Author : Hiroshi Maruta
  • Publisher : Academic Press
  • Release : 02 December 2021
GET THIS BOOKTumor Suppressing Viruses, Genes, and Drugs

Tumor Suppressing Viruses, Genes, and Drugs profiles the new generation of cancer treatments now in development. The book examines the innovative new approaches of viral, gene, and signal therapies that promise to replace or enhance conventional methods such as surgery, radiation, and chemotherapy. The timely information presented by this book should be of interest to anyone concerned with advancing cancer treatment beyond current medical practices.

Conquering RAS

Conquering RAS
  • Author : Asfar Azmi
  • Publisher : Academic Press
  • Release : 11 August 2016
GET THIS BOOKConquering RAS

Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging

Regulation of Cardiac Contractility

Regulation of Cardiac Contractility
  • Author : R. John Solaro
  • Publisher : Biota Publishing
  • Release : 01 April 2011
GET THIS BOOKRegulation of Cardiac Contractility

Contractility describes the relative ability of the heart to eject a stroke volume (SV) at a given prevailing afterload (arterial pressure) and preload (end-diastolic volume; EDV). Various measures of contractility are related to the fraction as the SV/EDV or the ejection fraction, and the dynamics of ejection as determined from maximum pressure rise in the ventricles or arteries or from aortic flow velocities determined by echocardiography. At the cellular level, the ultimate determinant of contractility is the relative tension

Inhibitors of the Ras Superfamily G-proteins, Part A

Inhibitors of the Ras Superfamily G-proteins, Part A
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 10 September 2013
GET THIS BOOKInhibitors of the Ras Superfamily G-proteins, Part A

This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field

Cytoskeleton and Small G Proteins

Cytoskeleton and Small G Proteins
  • Author : Philippe Jeanteur
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKCytoskeleton and Small G Proteins

The internal structure of a cell can be affected by signals in the form of small molecules outside the cell. These changes can then alter the shape or adhesiveness of the cell. This volume centers particularly on one family of cellular proteins which transmit these signals, the Rho Ras-like GTPases, and examines their role in normal cellular processes and development. Also discussed are their roles in cancer formation and microbial pathogenesis.

Physiologic and Pathologic Angiogenesis

Physiologic and Pathologic Angiogenesis
  • Author : Dan Simionescu,Agneta Simionescu
  • Publisher : BoD – Books on Demand
  • Release : 05 April 2017
GET THIS BOOKPhysiologic and Pathologic Angiogenesis

The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that

Interaction Between a Novel P21 Activated Kinase (PAK6) and Androgen Receptor in Prostate Cancer

Interaction Between a Novel P21 Activated Kinase (PAK6) and Androgen Receptor in Prostate Cancer
  • Author : Anonim
  • Publisher : Unknown Publisher
  • Release : 02 December 2021
GET THIS BOOKInteraction Between a Novel P21 Activated Kinase (PAK6) and Androgen Receptor in Prostate Cancer

The androgen-signaling pathway is important for the growth and progression of prostate cancer. The cell cycle signaling regulated by the mitogen activated protein/extracellular-signal-regulated kinase (MAPK/ERK) have been linked to tumorigenesis and tumor progression. The p2l-activated kinases (PAKs) are members of a growing class of Rac/Cdc42-associated Ste20-like ser/thr protein kinases. Recent studies have shown that MAPK/ERK signaling can be mediated via Cdc42/Rac-stimulation of PAK activity. Recently, we demonstrated a specific interaction between

Receptor Tyrosine Kinases: Family and Subfamilies

Receptor Tyrosine Kinases: Family and Subfamilies
  • Author : Deric L. Wheeler,Yosef Yarden
  • Publisher : Springer
  • Release : 31 July 2015
GET THIS BOOKReceptor Tyrosine Kinases: Family and Subfamilies

This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with a general introduction to that family and a comprehensive discussion of that receptor’s family in development and human disease. Following are in-depth analyses of each family’s receptors with

Innate Immunity of Plants, Animals and Humans

Innate Immunity of Plants, Animals and Humans
  • Author : Holger Heine
  • Publisher : Springer Science & Business Media
  • Release : 07 December 2007
GET THIS BOOKInnate Immunity of Plants, Animals and Humans

This book has been cunningly designed to provide an overview of our current knowledge about the innate immune systems of these three types of organisms. It not only covers the innate immune mechanisms and responses of such diverse organisms as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans. It delves too into the central defense mechanisms, antimicrobial peptides and the complement system.

Rho Gtpases: Molecular Biology In Health And Disease

Rho Gtpases: Molecular Biology In Health And Disease
  • Author : Fort Philippe,Blangy Anne
  • Publisher : World Scientific
  • Release : 12 December 2017
GET THIS BOOKRho Gtpases: Molecular Biology In Health And Disease

Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology. This book is divided into three parts. Part 1 gives an evolutionary perspective of the Rho family, its atypical members, and an overview of how Rho activity is regulated. Part 2 addresses two important aspects of multicellularity

Estrogens and Memory

Estrogens and Memory
  • Author : Karyn M. Frick
  • Publisher : Oxford University Press, USA
  • Release : 02 December 2021
GET THIS BOOKEstrogens and Memory

"A book about the influence of estrogens on memory would have been unthinkable as recently as 30 years ago. Although a few small studies in the late 1970's reported a beneficial effect of estrogens on memory in human women (Hackman and Galbraith, 1976; Fedor-Freybergh, 1977), examination of the role of estrogens in memory did not truly capture more widespread attention until the pioneering work of Barbara Sherwin and colleagues in 1988 and beyond. In her initial paper, Sherwin showed that bilateral removal of the