Palladium Catalyzed Modification of Nucleosides Nucleotides and Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity, this book provides an up-to-date reference for both professionals in industry and other interested parties. Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist

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  • Author : Anant R. Kapdi
  • Publisher : Elsevier
  • Pages : 358 pages
  • ISBN : 012811293X
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKPalladium Catalyzed Modification of Nucleosides Nucleotides and Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides
  • Author : Anant R. Kapdi,Debabrata Maiti,Yogesh S. Sanghvi
  • Publisher : Elsevier
  • Release : 04 June 2018
GET THIS BOOKPalladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the

Chemistry of Nucleic Acids

Chemistry of Nucleic Acids
  • Author : Harri Lönnberg
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release : 10 August 2020
GET THIS BOOKChemistry of Nucleic Acids

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.

Nucleic Acids Chemistry

Nucleic Acids Chemistry
  • Author : Ramon Eritja
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release : 18 January 2021
GET THIS BOOKNucleic Acids Chemistry

This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 24 April 2020
GET THIS BOOKAdvances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

Chemistry of Nucleic Acids

Chemistry of Nucleic Acids
  • Author : Harri Lönnberg
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release : 10 August 2020
GET THIS BOOKChemistry of Nucleic Acids

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.

Palladacycles

Palladacycles
  • Author : Anant Kapdi,Debabrata Maiti
  • Publisher : Elsevier
  • Release : 14 June 2019
GET THIS BOOKPalladacycles

Palladacycles: Catalysis and Beyond provides an overview of recent research in palladacycles in catalysis for cross-coupling and similar reactions. In the quest for developing highly efficient and robust palladium-based catalysts for C-C bond formation via cross-coupling reactions, palladacycles have played a significant role. In recent years, they have found a wide variety of applications, ranging from catalysts for cross-coupling and related reactions, to their more recent application as anticancer agents. This book explores early examples of the use of palladacyclic

C-H and C-X Bond Functionalization

C-H and C-X Bond Functionalization
  • Author : Xavi Ribas
  • Publisher : Royal Society of Chemistry
  • Release : 04 July 2022
GET THIS BOOKC-H and C-X Bond Functionalization

Cross-coupling reactions involving C-H and C-X bond functionalisation are commonplace in natural product synthesis and natural products, therapeutic agents, biological probes, and advanced materials. Much attention has been given to understanding the mechanistic strategies used to achieve this, making this a hot topic in recent years. In this edited book, contributions from across the globe examine these strategies, with a particular focus on palladium and copper, as well as iron u an emerging element in this field. Reviewing the recent

Synthesis of Therapeutic Oligonucleotides

Synthesis of Therapeutic Oligonucleotides
  • Author : Satoshi Obika,Mitsuo Sekine
  • Publisher : Springer
  • Release : 20 December 2018
GET THIS BOOKSynthesis of Therapeutic Oligonucleotides

This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers,

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry
  • Author : Alan R. Katritzky
  • Publisher : Academic Press
  • Release : 07 January 2011
GET THIS BOOKAdvances in Heterocyclic Chemistry

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. Provides up-to-date material on a fast-growing and highly topical subject area Contains the latest research covering a wide variety of heterocyclic topics Written by leading authorities and designed

Modified Nucleic Acids

Modified Nucleic Acids
  • Author : Kazuhiko Nakatani,Yitzhak Tor
  • Publisher : Springer
  • Release : 04 April 2016
GET THIS BOOKModified Nucleic Acids

This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book

Modified Nucleosides

Modified Nucleosides
  • Author : Piet Herdewijn
  • Publisher : John Wiley & Sons
  • Release : 08 September 2008
GET THIS BOOKModified Nucleosides

Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances. The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs. Essential reading for every scientist working in this area.

Nucleic Acids in Chemistry and Biology

Nucleic Acids in Chemistry and Biology
  • Author : G Michael Blackburn,Michael J Gait,David Loakes,David M Williams
  • Publisher : Royal Society of Chemistry
  • Release : 09 November 2015
GET THIS BOOKNucleic Acids in Chemistry and Biology

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and

Synthesis and Characterization of Glycosides

Synthesis and Characterization of Glycosides
  • Author : Marco Brito-Arias
  • Publisher : Springer
  • Release : 03 June 2016
GET THIS BOOKSynthesis and Characterization of Glycosides

This second edition is a short and comprehensive study on the best known approaches for preparing the main types of glycosides. It covers synthetic pathways of challenging glycosides known as antiviral or antineoplastic drugs, and synthetic substrates used for enzymatic detection, including those used for detection of gene markers in plant biotechnology. The author pays special attention to the structural characterization of glycosides and provides the basic tools for the structural assignment through NMR, X-Ray and mass spectra techniques. The

The Combinatorial Index

The Combinatorial Index
  • Author : Barry A. Bunin
  • Publisher : Elsevier
  • Release : 15 April 1998
GET THIS BOOKThe Combinatorial Index

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which