Palladium Catalyzed Modification of Nucleosides Nucleotides and Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity, this book provides an up-to-date reference for both professionals in industry and other interested parties. Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist

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  • Author : Anant R. Kapdi
  • Publisher : Elsevier
  • Pages : 358 pages
  • ISBN : 012811293X
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKPalladium Catalyzed Modification of Nucleosides Nucleotides and Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides
  • Author : Anant R. Kapdi,Debabrata Maiti,Yogesh S. Sanghvi
  • Publisher : Elsevier
  • Release : 04 June 2018
GET THIS BOOKPalladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the

Chemistry of Nucleic Acids

Chemistry of Nucleic Acids
  • Author : Harri Lönnberg
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release : 10 August 2020
GET THIS BOOKChemistry of Nucleic Acids

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.

C-H and C-X Bond Functionalization

C-H and C-X Bond Functionalization
  • Author : Xavi Ribas
  • Publisher : Royal Society of Chemistry
  • Release : 24 June 2021
GET THIS BOOKC-H and C-X Bond Functionalization

Cross-coupling reactions involving C-H and C-X bond functionalisation are commonplace in natural product synthesis and natural products, therapeutic agents, biological probes, and advanced materials. Much attention has been given to understanding the mechanistic strategies used to achieve this, making this a hot topic in recent years. In this edited book, contributions from across the globe examine these strategies, with a particular focus on palladium and copper, as well as iron u an emerging element in this field. Reviewing the recent

Synthesis of Therapeutic Oligonucleotides

Synthesis of Therapeutic Oligonucleotides
  • Author : Satoshi Obika,Mitsuo Sekine
  • Publisher : Springer
  • Release : 08 December 2018
GET THIS BOOKSynthesis of Therapeutic Oligonucleotides

This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers,

Current Organic Chemistry

Current Organic Chemistry
  • Author : Anonim
  • Publisher : Unknown Publisher
  • Release : 24 June 2021
GET THIS BOOKCurrent Organic Chemistry

Provides in depth reviews on current progress in the fields of asymmetric synthesis, organometallic chemistry, bioorganic chemistry, heterocyclic chemistry, natural product chemistry, and analytical methods in organic chemistry. Each issue is edited by an appointed Executive Guest Editor

Chemical Synthesis of Nucleoside Analogues

Chemical Synthesis of Nucleoside Analogues
  • Author : Pedro Merino
  • Publisher : John Wiley & Sons
  • Release : 12 February 2013
GET THIS BOOKChemical Synthesis of Nucleoside Analogues

Compiles current tested and proven approaches tosynthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists fromaround the world, this book brings together and describes testedand proven approaches for the chemical synthesis of common familiesof nucleoside analogues. Readers will learn to create newnucleoside analogues with desired therapeutic properties by using avariety of methods to chemically modify natural nucleosides,including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo-

Modified Nucleic Acids

Modified Nucleic Acids
  • Author : Kazuhiko Nakatani,Yitzhak Tor
  • Publisher : Springer
  • Release : 04 April 2016
GET THIS BOOKModified Nucleic Acids

This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book

Strategies for Palladium-Catalyzed Non-directed and Directed C-H Bond Functionalization

Strategies for Palladium-Catalyzed Non-directed and Directed C-H Bond Functionalization
  • Author : Anant R. Kapdi,Debabrata Maiti
  • Publisher : Elsevier
  • Release : 23 June 2017
GET THIS BOOKStrategies for Palladium-Catalyzed Non-directed and Directed C-H Bond Functionalization

Strategies for Palladium-Catalyzed Non-directed and Directed C-H Bond Functionalization portrays the complete scope of these two aspects of C-H bond functionalization in a single volume for the first time. Featured topics include the influence of palladacyclic systems in C-H bond functionalization (need for newer catalytic systems for better efficiency), mechanistic aspect of the functionalization strategies leading to better systems, and applications of these methodologies to natural product synthesis and material synthesis. Addresses the involvement of catalytic systems (palladacycles) for better

Catalyst Components for Coupling Reactions

Catalyst Components for Coupling Reactions
  • Author : Gary A. Molander
  • Publisher : John Wiley & Sons Incorporated
  • Release : 24 June 1999
GET THIS BOOKCatalyst Components for Coupling Reactions

The long awaited Handbook for all synthetic chemists working on coupling reactions, compiling all major catalyst components in use in the area. Consists of a compilation of articles taken from the EROS database, with the inclusion of about 20 newly commissioned catalysts/pre-catalysts/ligands that have made an impact in this area of synthetic organic chemistry. Includes catalyst systems used in Heck, Kumada-Tamao-Corriu, Suzuki-Miyaura, Hiyama-Hatanaka, Negishi, Migita-Kosugi-Stille, Buchwald-Hartwig, and Tsuji-Trost coupling reactions.

The Combinatorial Index

The Combinatorial Index
  • Author : Barry A. Bunin
  • Publisher : Elsevier
  • Release : 15 April 1998
GET THIS BOOKThe Combinatorial Index

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which

Palladacycles

Palladacycles
  • Author : Anant Kapdi,Debabrata Maiti
  • Publisher : Elsevier
  • Release : 14 June 2019
GET THIS BOOKPalladacycles

Palladacycles: Catalysis and Beyond provides an overview of recent research in palladacycles in catalysis for cross-coupling and similar reactions. In the quest for developing highly efficient and robust palladium-based catalysts for C-C bond formation via cross-coupling reactions, palladacycles have played a significant role. In recent years, they have found a wide variety of applications, ranging from catalysts for cross-coupling and related reactions, to their more recent application as anticancer agents. This book explores early examples of the use of palladacyclic

Affinity Modification Of Biopolymers

Affinity Modification Of Biopolymers
  • Author : Dmitri G Knorre
  • Publisher : CRC Press
  • Release : 18 January 2018
GET THIS BOOKAffinity Modification Of Biopolymers

The goal of this book is to give a systematic description of the main principles of affinity modification and applications, consideration of possibilities, and restrictions of the method. Modification within specific complexes is a special case of chemical modification which is widely used in the nonaddressed version in biochemistry and related areas. Therefore, we have included in the first introductory paper chapter of the book general considerations of chemical modifications of biopolymers and the application of biopolymers.

Nucleic Acids in Chemistry and Biology

Nucleic Acids in Chemistry and Biology
  • Author : G Michael Blackburn,Michael J Gait,David Loakes,David M Williams
  • Publisher : Royal Society of Chemistry
  • Release : 09 November 2015
GET THIS BOOKNucleic Acids in Chemistry and Biology

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and

Aqueous Organometallic Catalysis

Aqueous Organometallic Catalysis
  • Author : Ferenc Joó
  • Publisher : Springer Science & Business Media
  • Release : 11 April 2006
GET THIS BOOKAqueous Organometallic Catalysis

Over the past 20 years aqueous organometallic catalysis has found applications in small- scale organic synthesis in the laboratory, as well as in the industrial production of chemicals with a combined output close to one million tons per year. Aqueous/organic two-phase reactions allow easy product-catalyst separation and full catalyst recovery which mean clear benefits not only in economic but also in environmental and green chemistry contexts. Instead of putting together a series of expert reviews of specialized fields, this book