Patient Derived Tumor Xenograft Models

Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory. Offers guidance on data interpretation and regulatory aspects Provides useful techniques and strategies for working with PDX models Includes practical tools and potential pitfalls for best practices Compiles all knowledge of PDX models research in one resource Presents the results of first ever global survey on standards of PDX development and usage in academia and industry

Produk Detail:

  • Author : Rajesh Uthamanthil
  • Publisher : Academic Press
  • Pages : 486 pages
  • ISBN : 0128040610
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKPatient Derived Tumor Xenograft Models

Patient Derived Tumor Xenograft Models

Patient Derived Tumor Xenograft Models
  • Author : Rajesh Uthamanthil,Peggy Tinkey,Elisa de Stanchina
  • Publisher : Academic Press
  • Release : 13 October 2016
GET THIS BOOKPatient Derived Tumor Xenograft Models

Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is

Patient-Derived Xenograft Models of Human Cancer

Patient-Derived Xenograft Models of Human Cancer
  • Author : Yuzhuo Wang,Dong Lin,Peter W. Gout
  • Publisher : Springer
  • Release : 29 June 2017
GET THIS BOOKPatient-Derived Xenograft Models of Human Cancer

This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing

Patient-Derived Mouse Models of Cancer

Patient-Derived Mouse Models of Cancer
  • Author : Robert M. Hoffman
  • Publisher : Springer
  • Release : 31 August 2017
GET THIS BOOKPatient-Derived Mouse Models of Cancer

This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also

Tumor Models in Cancer Research

Tumor Models in Cancer Research
  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release : 01 December 2010
GET THIS BOOKTumor Models in Cancer Research

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some

HIV-1 Latency

HIV-1 Latency
  • Author : Guido Silvestri,Mathias Lichterfeld
  • Publisher : Springer
  • Release : 11 October 2018
GET THIS BOOKHIV-1 Latency

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches

Anticancer Drug Development Guide

Anticancer Drug Development Guide
  • Author : Beverly A. Teicher,Paul A. Andrews
  • Publisher : Springer Science & Business Media
  • Release : 01 February 2004
GET THIS BOOKAnticancer Drug Development Guide

This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules.

Anticancer Drug Development

Anticancer Drug Development
  • Author : David J. Kerr
  • Publisher : Unknown Publisher
  • Release : 12 April 2021
GET THIS BOOKAnticancer Drug Development

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. KEY FEATURES: * One work that can be consulted for

Tumor Organoids

Tumor Organoids
  • Author : Shay Soker,Aleksander Skardal
  • Publisher : Humana Press
  • Release : 20 October 2017
GET THIS BOOKTumor Organoids

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering

Mouse Models of Cancer

Mouse Models of Cancer
  • Author : Cory Abate-Shen,Katerina Politi,Lewis A. Chodosh,Kenneth P. Olive
  • Publisher : Unknown Publisher
  • Release : 30 November 2013
GET THIS BOOKMouse Models of Cancer

Too often both composition teachers and their students experience knowledge and authority as lying outside their rhetorical interactions with others. Drawing on feminist, cultural, and poststructuralist theory, as well as work in the rhetorical tradition and composition studies, Hill offers less debilitating methods of thinking that teachers can model for their students. Richly illustrated with examples of classroom interactions and student work, the book also shows teachers how to enrich their own intellectual and political lives within the academy.

Patient Surveillance After Cancer Treatment

Patient Surveillance After Cancer Treatment
  • Author : Frank E Johnson,Yoshihiko Maehara,George P Browman,Julie A. Margenthaler,Riccardo A. Audisio,John F Thompson,David Y. Johnson,Craig C. Earle,Katherine S. Virgo
  • Publisher : Springer Science & Business Media
  • Release : 12 March 2013
GET THIS BOOKPatient Surveillance After Cancer Treatment

Patient Surveillance After Cancer Treatment covers the history of cancer patient surveillance after curative-intent treatment, the rationale, the methodologies used in the past and at present, the methodologies that will probably emerge in the future, the costs of surveillance, the definitions of various terms used in the field, and how those who are interested in the topic can get more information about it from the internet. The secondary focus of the book is to publicize the need for well-designed, adequately

Esophageal Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma
  • Author : Alfred K. Lam
  • Publisher : Humana
  • Release : 28 February 2021
GET THIS BOOKEsophageal Squamous Cell Carcinoma

This volume provides current management and research protocols on oesophageal squamous cell carcinoma. Chapters guide readers through methods on clinical and pathological diagnostics, translational research for oesophageal squamous cell carcinoma, in vitro assays, liquid biopsy for cancer DNA and circulating tumour cells, genomic analysis, mi-RNAs, and proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on

Establishing a Hematopoietic Stem Cell Transplantation Unit

Establishing a Hematopoietic Stem Cell Transplantation Unit
  • Author : Éliane Gluckman,Dietger Niederwieser,Mahmoud Aljurf
  • Publisher : Springer
  • Release : 17 November 2017
GET THIS BOOKEstablishing a Hematopoietic Stem Cell Transplantation Unit

This text aims to provide simplified practical guidelines to start a hematopoietic stem cell transplantation unit which could be implemented in most centers and countries worldwide. The book also provides guidelines for existing transplantation units to upgrade their practice and implement new policies and procedures, in addition to developing therapies according to latest international standards and regulations. The book covers a wide range of practical implementation tools including HSCT program team structure, building inpatient and outpatient HSCT units, requisite laboratory

Cancer Models

Cancer Models
  • Author : Michael Breitenbach,Jens Hoffmann
  • Publisher : Frontiers Media SA
  • Release : 05 February 2019
GET THIS BOOKCancer Models

Cancer research, like research on other diseases, highly depends on representative and reliable model systems. In the Research Topic “Cancer Models”, we collected original papers and review articles addressing the topic of tumor modeling from molecular biology, biochemistry, microorganisms, cells and organoids, fishes, animals and xenografts, up to computational cancer models and patient data analysis. This representative eBook describes that there is not a single molecular defined tumor but rather a heterogenic and highly variable complex of different individual diseases.

Intestinal Stem Cells

Intestinal Stem Cells
  • Author : Paloma Ordóñez-Morán
  • Publisher : Humana
  • Release : 16 August 2020
GET THIS BOOKIntestinal Stem Cells

This detailed book encapsulates the most up-to-date methods of the intestinal stem cell field and provides guidance on a variety of techniques for studying intestinal stem cells properties. Beginning with a section on in vitro techniques to study different aspects of the intestinal stem cell functions by innovative imaging and functional assays, the volume continues with chapters detailing the single-cell transcriptional profiling method, the isolation of intestinal crypts to generate and establish 3D organoids, as well as different animal models

Pediatric and Adolescent Osteosarcoma

Pediatric and Adolescent Osteosarcoma
  • Author : Norman Jaffe,Oyvind S. Bruland,Stefan Bielack
  • Publisher : Springer Science & Business Media
  • Release : 10 March 2010
GET THIS BOOKPediatric and Adolescent Osteosarcoma

Pediatric and Adolescent Osteosarcoma provides a historical review of the nature of osteosarcoma and the conflict that accompanied the introduction of adjuvant therapy for osteosarcoma culminating in accepted and prevailing methods of current therapy. It outlines concepts in Epidemiology and Etiology, and provides chapters on pathology and radiologic characteristics of osteosarcoma, surgical therapy tailored specifically for treatment of primary tumors in pediatric/adolescent age group, treatment of pulmonary and extra pulmonary metastases and complications, as well as the role of