Physiologically Based Pharmacokinetic PBPK Modeling

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more. Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research Authored by expert editors and contributors who are among the best PBPK modelers in the world

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  • Author : Jeffrey W. Fisher
  • Publisher : Academic Press
  • Pages : 346 pages
  • ISBN : 0128196823
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKPhysiologically Based Pharmacokinetic PBPK Modeling

Physiologically Based Pharmacokinetic (PBPK) Modeling

Physiologically Based Pharmacokinetic (PBPK) Modeling
  • Author : Jeffrey W. Fisher,Jeffery M. Gearhart,Zhoumeng Lin
  • Publisher : Academic Press
  • Release : 20 May 2020
GET THIS BOOKPhysiologically Based Pharmacokinetic (PBPK) Modeling

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety

Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations

Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations
  • Author : Sheila Annie Peters
  • Publisher : John Wiley & Sons
  • Release : 17 February 2012
GET THIS BOOKPhysiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations

The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of PBPK modeling as used inpharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)Modeling and Simulations fills this void. Connecting theory with practice, the book explores theincredible potential of PBPK modeling for improving drug discoveryand

Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling
  • Author : Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III
  • Publisher : John Wiley & Sons
  • Release : 14 June 2005
GET THIS BOOKPhysiologically Based Pharmacokinetic Modeling

A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book presents an overview of the underlying principles of PBPKmodel development. Then it provides a compendium of PBPK modelinginformation, including historical development, specific modelingchallenges, and current practices for: * Halogenated Alkanes * Halogenated

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition
  • Author : Johan Gabrielsson,Daniel Weiner
  • Publisher : CRC Press
  • Release : 30 November 2001
GET THIS BOOKPharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition

This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between

Fundamentals of Pediatric Drug Dosing

Fundamentals of Pediatric Drug Dosing
  • Author : Iftekhar Mahmood,Gilbert Burckart
  • Publisher : Springer
  • Release : 28 October 2016
GET THIS BOOKFundamentals of Pediatric Drug Dosing

Focused on pediatric physiology, pharmacology, pharmacokinetics and pharmacodynamics, this book illustrates the differences between the pediatric population and adults; knowledge of extreme importance not only during pediatric drug development but also in the clinical practice. Physicians, nurses, clinical pharmacologists, researchers and healthcare professionals will find this an invaluable resource. With the advent of pediatric exclusivity, and requirements to conduct clinical studies in children, an emphasis has been placed on finding a safe and efficacious dose of a drug in children.

Quantitative Modeling in Toxicology

Quantitative Modeling in Toxicology
  • Author : Kannan Krishnan,Melvin E. Andersen
  • Publisher : John Wiley & Sons
  • Release : 01 April 2010
GET THIS BOOKQuantitative Modeling in Toxicology

Governments around the world are passing laws requiring industry to assess the toxicity of the chemicals and products they produce, but to do so while reducing, refining, or even replacing testing on animals. To meet these requirements, experimental toxicologists and risk assessors are adopting quantitative approaches and computer simulations to study the biological fate and effects of chemicals and drugs. In Quantitative Modeling in Toxicology leading experts outline the current state of knowledge on the modeling of dose, tissue interactions

Toxicokinetics and Risk Assessment

Toxicokinetics and Risk Assessment
  • Author : John C. Lipscomb,Edward V. Ohanian
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKToxicokinetics and Risk Assessment

Toxicokinetics in Risk Assessment discusses the noncancer risk assessment process and its reliance on uncertainty factors in order to facilitate the continued study and refinement of the scientific basis for health risk assessment. This text clearly demonstrates the application of physiologically-based pharmacokinetic (PBPK) modeling in human healt

Ecotoxicology Modeling

Ecotoxicology Modeling
  • Author : James Devillers
  • Publisher : Springer Science & Business Media
  • Release : 07 August 2009
GET THIS BOOKEcotoxicology Modeling

Ecotoxicology Modeling is a comprehensive and well-documented text providing a collection of computational methods to the ecotoxicologists primarily interested in the study of the adverse effects of chemicals, their mechanisms of action and/or their environmental fate and behavior. Avoiding mathematical jargon, the book presents numerous case studies to enable the reader to understand the interest but also the limitations of linear and nonlinear models in ecotoxicology. Written by an international team of scientists, Ecotoxicology Modeling is of primary interest

Intracellular Delivery III

Intracellular Delivery III
  • Author : Aleš Prokop,Volkmar Weissig
  • Publisher : Springer
  • Release : 31 October 2016
GET THIS BOOKIntracellular Delivery III

A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes

Pharmacokinetic-Pharmacodynamic Modeling and Simulation

Pharmacokinetic-Pharmacodynamic Modeling and Simulation
  • Author : Peter L. Bonate
  • Publisher : Springer Science & Business Media
  • Release : 14 May 2006
GET THIS BOOKPharmacokinetic-Pharmacodynamic Modeling and Simulation

A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops

HIV and Aging

HIV and Aging
  • Author : M. Brennan-Ing,R.F. DeMarco
  • Publisher : Karger Medical and Scientific Publishers
  • Release : 22 November 2016
GET THIS BOOKHIV and Aging

Despite decades of attention on building a global HIV research and programming agenda, HIV in older populations has generally been neglected until recently. This new book focuses on HIV and aging in the context of ageism with regard to prevention, treatment guidelines, funding, and the engagement of communities and health and social service organizations. The lack of perceived HIV risk in late adulthood among older people themselves, as well on the part of providers and society in general, has led

Human Biomonitoring for Environmental Chemicals

Human Biomonitoring for Environmental Chemicals
  • Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human Biomonitoring for Environmental Toxicants
  • Publisher : National Academies Press
  • Release : 30 October 2006
GET THIS BOOKHuman Biomonitoring for Environmental Chemicals

Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand

Pharmaceutical Nanotechnology

Pharmaceutical Nanotechnology
  • Author : Jean Cornier
  • Publisher : John Wiley & Sons
  • Release : 06 February 2017
GET THIS BOOKPharmaceutical Nanotechnology

With its focus on concrete methods and recent advances in applying nanotechnology to develop new drug therapies and medical diagnostics, this book provides an overall picture of the field, from the fundamentals of nanopharmacy with the characterisation and manufacturing methods to the role of nanoparticles and substances. Actual examples of utilization include drug development issues, translation to the clinic, market prospects, and industrial commercialization aspects. The applications described are taken from cancer treatment as well as other major therapeutic areas,

Anesthetic Pharmacology

Anesthetic Pharmacology
  • Author : Alex S. Evers,Mervyn Maze,Evan D. Kharasch
  • Publisher : Cambridge University Press
  • Release : 10 March 2011
GET THIS BOOKAnesthetic Pharmacology

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews

Chemical Mixtures and Combined Chemical and Nonchemical Stressors

Chemical Mixtures and Combined Chemical and Nonchemical Stressors
  • Author : Cynthia V. Rider,Jane Ellen Simmons
  • Publisher : Springer
  • Release : 16 February 2018
GET THIS BOOKChemical Mixtures and Combined Chemical and Nonchemical Stressors

In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical