Polymer Protein Conjugates

Polymer-Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. Provides an overview on the state-of-the-art of protein polymer conjugation Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes Outlines advantages and potential risks of present technology based on PEG Offers new alternatives for PEG and new approaches for on site-selective protein modification Identifies future direction of research in this field

Produk Detail:

  • Author : Gianfranco Pasut
  • Publisher : Anonim
  • Pages : 312 pages
  • ISBN : 9780444640819
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKPolymer Protein Conjugates

Polymer-Protein Conjugates

Polymer-Protein Conjugates
  • Author : Gianfranco Pasut,Samuel Zalipsky
  • Publisher : Unknown Publisher
  • Release : 01 November 2019
GET THIS BOOKPolymer-Protein Conjugates

Polymer-Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role

Polymer-Protein Conjugates

Polymer-Protein Conjugates
  • Author : Gianfranco Pasut,Samuel Zalipsky
  • Publisher : Elsevier
  • Release : 30 October 2019
GET THIS BOOKPolymer-Protein Conjugates

Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this

PEGylated Protein Drugs: Basic Science and Clinical Applications

PEGylated Protein Drugs: Basic Science and Clinical Applications
  • Author : Francesco M. Veronese
  • Publisher : Springer Science & Business Media
  • Release : 30 December 2009
GET THIS BOOKPEGylated Protein Drugs: Basic Science and Clinical Applications

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

Self-Assembly

Self-Assembly
  • Author : Ramanathan Nagarajan
  • Publisher : John Wiley & Sons
  • Release : 07 January 2019
GET THIS BOOKSelf-Assembly

An introduction to the state-of-the-art of the diverse self-assembly systems Self-Assembly: From Surfactants to Nanoparticles provides an effective entry for new researchers into this exciting field while also giving the state of the art assessment of the diverse self-assembling systems for those already engaged in this research. Over the last twenty years, self-assembly has emerged as a distinct science/technology field, going well beyond the classical surfactant and block copolymer molecules, and encompassing much larger and complex molecular, biomolecular and

Bio-inspired Polymers

Bio-inspired Polymers
  • Author : Nico Bruns,Andreas F M Kilbinger
  • Publisher : Royal Society of Chemistry
  • Release : 14 October 2016
GET THIS BOOKBio-inspired Polymers

Many key aspects of life are based on naturally occurring polymers, such as polysaccharides, proteins and DNA. Unsurprisingly, their molecular functionalities, macromolecular structures and material properties are providing inspiration for designing new polymeric materials with specific functions, for example, responsive, adaptive and self-healing materials. Bio-inspired Polymers covers all aspects of the subject, ranging from the synthesis of novel polymers, to structure-property relationships, materials with advanced properties and applications of bio-inspired polymers in such diverse fields as drug delivery, tissue engineering,

Bioconjugate Techniques

Bioconjugate Techniques
  • Author : Greg T. Hermanson
  • Publisher : Academic Press
  • Release : 25 July 2013
GET THIS BOOKBioconjugate Techniques

Bioconjugate Techniques, 3rd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions, with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers.

Protein-based Engineered Nanostructures

Protein-based Engineered Nanostructures
  • Author : Aitziber L. Cortajarena,Tijana Z. Grove
  • Publisher : Springer
  • Release : 27 September 2016
GET THIS BOOKProtein-based Engineered Nanostructures

This book is devoted to the engineering of protein-based nanostructures and nanomaterials. One key challenge in nanobiotechnology is to be able to exploit the natural repertoire of protein structures and functions to build materials with defined properties at the nanoscale using “bottom-up” strategies. This book addresses in an integrated manner all the critical aspects that need to be understood and considered to design the next generation of nano-bio assemblies. The book covers first the fundamentals of the design and features

Renewable Resources for Functional Polymers and Biomaterials

Renewable Resources for Functional Polymers and Biomaterials
  • Author : Peter Williams
  • Publisher : Royal Society of Chemistry
  • Release : 09 November 2015
GET THIS BOOKRenewable Resources for Functional Polymers and Biomaterials

This book details polysaccharides and other important biomacromolecules covering their source, production, structures, properties, and current and potential application in the fields of biotechnology and medicine. It includes a systematic discussion on the general strategies of isolation, separation and characterization of polysaccharides and proteins. Subsequent chapters are devoted to polysaccharides obtained from various sources, including botanical, algal, animal and microbial. In the area of botanical polysaccharides, separate chapters are devoted to the sources, structure, properties and medical applications of cellulose

Natural Polymers for Drug Delivery

Natural Polymers for Drug Delivery
  • Author : Harsha Kharkwal,Srinivas Janaswamy
  • Publisher : CABI
  • Release : 07 December 2016
GET THIS BOOKNatural Polymers for Drug Delivery

Natural polymers have been utilized extensively in food, pharmaceuticals, cosmetics, textiles, oil drilling and paint industries. Their non-toxic and inexpensive attributes readily enhance their commercial acceptability and make them potent agents in lieu of synthetic polymers. This book explores the opportunistic utility of natural polymers in developing effective drug delivery systems and provides a comprehensive and up-to-date analysis of their source, chemical structure and mechanism of action. Covering novel polymers for drug delivery - in particular extracts from plants, microorganisms

Synthesis and Applications of Copolymers

Synthesis and Applications of Copolymers
  • Author : Anbanandam Parthiban
  • Publisher : John Wiley & Sons
  • Release : 23 June 2014
GET THIS BOOKSynthesis and Applications of Copolymers

Understanding the reactivity of monomers is crucial in creating copolymers and determining the outcome of copolymerization. Covering the fundamental aspects of polymerization, Synthesis and Applications of Copolymers explores the reactivity of monomers and reaction conditions that ensure that the newly formed polymeric materials exhibit desired properties. Referencing a wide-range of disciplines, the book provides researchers, students, and scientists with the preparation of a diverse variety of copolymers and their recent developments, with a particular focus on copolymerization, crystallization, and techniques

Cyclodextrins

Cyclodextrins
  • Author : Wanda Sliwa,Tomasz Girek
  • Publisher : John Wiley & Sons
  • Release : 22 December 2016
GET THIS BOOKCyclodextrins

Authored by two experts working in this important field of research, the timely book covers the latest advances in the synthesis of cyclodextrins, their properties and important industrial applications. To this end, the authors describe covalent and non-covalent assemblies, cyclodextrin inclusion complexes, cyclodextrin polymers, and modified cyclodextrins, resulting in an up-to-date overview of cyclodextrin chemistry. An invaluable reference for organic and polymer chemists in academia as well as those researchers in industry working in polymer, supramolecular and pharmaceutical chemistry, as