Principles of Asymmetric Synthesis

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations. Authoritative glossary to aid understanding of stereochemical terminology Explanations of the key factors influencing stereoselectivity with numerous examples, organized by reaction type A handy reference guide to the literature of asymmetric synthesis for practitioners in the field

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  • Author : Robert E. Gawley
  • Publisher : Elsevier
  • Pages : 555 pages
  • ISBN : 0080448607
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKPrinciples of Asymmetric Synthesis

Principles of Asymmetric Synthesis

Principles of Asymmetric Synthesis
  • Author : Robert E. Gawley,Jeffrey Aubé
  • Publisher : Elsevier
  • Release : 18 September 2021
GET THIS BOOKPrinciples of Asymmetric Synthesis

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance

Principles of Asymmetric Synthesis

Principles of Asymmetric Synthesis
  • Author : R.E. Gawley,J. Aubé
  • Publisher : Elsevier
  • Release : 21 November 1996
GET THIS BOOKPrinciples of Asymmetric Synthesis

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance

Principles and Applications of Asymmetric Synthesis

Principles and Applications of Asymmetric Synthesis
  • Author : Guo-Qiang Lin,Yue-Ming Li,Albert S. C. Chan
  • Publisher : John Wiley & Sons
  • Release : 29 May 2003
GET THIS BOOKPrinciples and Applications of Asymmetric Synthesis

Asymmetric synthesis remains a challenge to practicing scientistsas the need for enantiomerically pure or enriched compoundscontinues to increase. Over the last decade, a large amount ofliterature has been published in this field. Principles andApplications of Asymmetric Synthesis consolidates and evaluates themost useful methodologies into a one-volume resource for theconvenience of practicing scientists and students. Authored by internationally renowned scientists in the field, thisreliable reference covers more than 450 reactions and includesimportant stoichiometric as well as catalytic asymmetric reactions.The first chapter

Asymmetric Synthesis

Asymmetric Synthesis
  • Author : Garry Procter
  • Publisher : Oxford University Press on Demand
  • Release : 18 September 1996
GET THIS BOOKAsymmetric Synthesis

This book covers a wide range of reactions which are of importance in the asymmetric synthesis of organic compounds. The principles of asymmetric additions to carbonyls, enolate alkylation, aldol reactions, additions to C-C double bonds, reduction and oxidation, rearrangements, and hydrolysis/ esterification reactions are covered, and selected examples used to illustrated the various topics. Numerous references to original literature should be of ues to organic chemists interested in the area of asymmetric synthesis.

Fundamentals of Asymmetric Catalysis

Fundamentals of Asymmetric Catalysis
  • Author : Patrick J. Walsh,Marisa C. Kozlowski
  • Publisher : University Science Books
  • Release : 02 January 2009
GET THIS BOOKFundamentals of Asymmetric Catalysis

This book describes the essential aspects of enantioselective catalysis in a clear, logical fashion, with chapters organized by concept rather than by reaction type. Each concept in Fundamentals of Asymmetric Catalysis is supported by carefully selected examples of a wide range of catalysts, reactions and reaction mechanisms.

Principles of Asymmetric Synthesis

Principles of Asymmetric Synthesis
  • Author : Robert E. Gawley,Jeffrey Aubé
  • Publisher : Elsevier Science Limited
  • Release : 18 September 1996
GET THIS BOOKPrinciples of Asymmetric Synthesis

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance

Principles of Organic Synthesis

Principles of Organic Synthesis
  • Author : Richard O.C. Norman
  • Publisher : Routledge
  • Release : 19 October 2017
GET THIS BOOKPrinciples of Organic Synthesis

This book is designed for those who have had no more than a brief introduction to organic chemistry and who require a broad understanding of the subject. The book is in two parts. In Part I, reaction mechanism is set in its wider context of the basic principles and concepts that underlie chemical reactions: chemical thermodynamics, structural theory, theories of reaction kinetics, mechanism itself and stereochemistry. In Part II these principles and concepts are applied to the formation of particular

Organic Chemistry from Retrosynthesis to Asymmetric Synthesis

Organic Chemistry from Retrosynthesis to Asymmetric Synthesis
  • Author : Vitomir Šunjić,Vesna Petrović Peroković
  • Publisher : Springer
  • Release : 30 April 2016
GET THIS BOOKOrganic Chemistry from Retrosynthesis to Asymmetric Synthesis

This book connects a retrosynthetic or disconnection approach with synthetic methods in the preparation of target molecules from simple, achiral ones to complex, chiral structures in the optically pure form. Retrosynthetic considerations and asymmetric syntheses are presented as closely related topics, often in the same chapter, underlining the importance of retrosynthetic consideration of target molecules neglecting stereochemistry and equipping readers to overcome the difficulties they may encounter in the planning and experimental implementation of asymmetric syntheses. This approach prepares students

Principles and Applications of Asymmetric Synthesis

Principles and Applications of Asymmetric Synthesis
  • Author : Guo-Qiang Lin,Yue-Ming Li,Albert S. C. Chan
  • Publisher : John Wiley & Sons
  • Release : 21 February 2001
GET THIS BOOKPrinciples and Applications of Asymmetric Synthesis

Asymmetric synthesis remains a challenge to practicing scientists as the need for enantiomerically pure or enriched compounds continues to increase. Over the last decade, a large amount of literature has been published in this field. Principles and Applications of Asymmetric Synthesis consolidates and evaluates the most useful methodologies into a one-volume resource for the convenience of practicing scientists and students. Authored by internationally renowned scientists in the field, this reliable reference covers more than 450 reactions and includes important stoichiometric as

Stereochemistry and Organic Reactions

Stereochemistry and Organic Reactions
  • Author : Dipak Kumar Mandal
  • Publisher : Academic Press
  • Release : 26 April 2021
GET THIS BOOKStereochemistry and Organic Reactions

Stereochemistry and Organic Reactions: Conformation, Configuration, Stereoelectronic Effects and Asymmetric Synthesis provides coverage on the stereochemistry of reactions of all mechanistic types, ranging from ionic, pericyclic and transition metal-catalyzed to radical and photochemical. Chapters cover acyclic molecules, cyclic molecules, the stereochemistry of organic reactions, the perturbation molecular orbital theory for the origin of stereoelectronic effects, and an introduction to the principles of stereoselectivity and hierarchical levels of asymmetric synthesis. Each chapter includes problems that reinforce main themes, making it valuable

Asymmetric Phase Transfer Catalysis

Asymmetric Phase Transfer Catalysis
  • Author : Keiji Maruoka
  • Publisher : John Wiley & Sons
  • Release : 31 March 2008
GET THIS BOOKAsymmetric Phase Transfer Catalysis

Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.

Asymmetric Catalysis In Organic Synthesis

Asymmetric Catalysis In Organic Synthesis
  • Author : Ryoji Noyori
  • Publisher : Wiley-Interscience
  • Release : 03 February 1994
GET THIS BOOKAsymmetric Catalysis In Organic Synthesis

Deals with basic principles of asymmetric catalysis focusing on its synthetic significance. Covers homogeneous asymmetric hydrogenation, asymmetric catalysis via chiral metal complexes, heterogeneous catalysis and non-organometallic catalysis. The collection of a range of stereoselective reactions illustrate various strategies and methodologies as well as their general utility.