Quantitative Systems Pharmacology

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource. Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy Discusses how drugs are driven to specific targets using nanoparticles Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation

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  • Author : Davide Manca
  • Publisher : Elsevier
  • Pages : 418 pages
  • ISBN : 0444639675
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKQuantitative Systems Pharmacology

Quantitative Systems Pharmacology

Quantitative Systems Pharmacology
  • Author : Davide Manca
  • Publisher : Elsevier
  • Release : 18 July 2018
GET THIS BOOKQuantitative Systems Pharmacology

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of

The Emerging Discipline of Quantitative Systems Pharmacology

The Emerging Discipline of Quantitative Systems Pharmacology
  • Author : Tarek A. Leil,Sergey Ermakov
  • Publisher : Unknown Publisher
  • Release : 07 September 2015
GET THIS BOOKThe Emerging Discipline of Quantitative Systems Pharmacology

In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems

Systems Pharmacology and Pharmacodynamics

Systems Pharmacology and Pharmacodynamics
  • Author : Donald E. Mager,Holly H.C. Kimko
  • Publisher : Springer
  • Release : 29 November 2016
GET THIS BOOKSystems Pharmacology and Pharmacodynamics

While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies

Pharmacometrics

Pharmacometrics
  • Author : Ene I. Ette,Paul J. Williams
  • Publisher : John Wiley & Sons
  • Release : 14 March 2013
GET THIS BOOKPharmacometrics

Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians.

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases
  • Author : Honghui Zhou,Diane R. Mould
  • Publisher : Wiley
  • Release : 19 March 2019
GET THIS BOOKQuantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases

Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen

Quantitative Pharmacology

Quantitative Pharmacology
  • Author : Johan Gabrielsson,Stephan Hjorth
  • Publisher : Swedish Pharmaceutical Press
  • Release : 07 May 2012
GET THIS BOOKQuantitative Pharmacology

PKPD awareness is vital if we are to attempt to relate preclinical results to the acute and long term consequences in humans. The debate on whether preclinical findings can be translated to the human usage is still engaging scientists across industry, academia and regulatory bodies. Pharmacokinetics (PK) and pharmacodynamics (PD) comprise traditionally distinct disciplines within pharmacology, the study of the interaction of drugs with the body. It is our intention to show that by deliberately, intimately and systematically integrate these

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition
  • Author : Johan Gabrielsson,Daniel Weiner
  • Publisher : CRC Press
  • Release : 30 November 2001
GET THIS BOOKPharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition

This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between

Clinical Trial Simulations

Clinical Trial Simulations
  • Author : Holly H. C. Kimko,Carl C. Peck
  • Publisher : Springer Science & Business Media
  • Release : 09 December 2010
GET THIS BOOKClinical Trial Simulations

This edition includes both updates and new uses and issues concerning CTS, along with case studies of how clinical trial simulations are being applied in various therapeutic and application areas. Importantly, the book expands on the utility of CTS for informing decisions during drug development and regulatory review. Each chapter author was selected on the basis of demonstrated expertise in state-of-the-art application of CTS. The target audience for this volume includes researchers and scientists who wish to consider use of

Concepts and Principles of Pharmacology

Concepts and Principles of Pharmacology
  • Author : James E. Barrett,Clive P. Page,Martin C. Michel
  • Publisher : Springer Nature
  • Release : 24 December 2019
GET THIS BOOKConcepts and Principles of Pharmacology

Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

Development of Innovative Drugs via Modeling with MATLAB

Development of Innovative Drugs via Modeling with MATLAB
  • Author : Ronald Gieschke,Daniel Serafin
  • Publisher : Springer Science & Business Media
  • Release : 27 November 2013
GET THIS BOOKDevelopment of Innovative Drugs via Modeling with MATLAB

The development of innovative drugs is becoming more difficult while relying on empirical approaches. This inspired all major pharmaceutical companies to pursue alternative model-based paradigms. The key question is: How to find innovative compounds and, subsequently, appropriate dosage regimens? Written from the industry perspective and based on many years of experience, this book offers: - Concepts for creation of drug-disease models, introduced and supplemented with extensive MATLAB programs - Guidance for exploration and modification of these programs to enhance the

Systems Medicine

Systems Medicine
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 24 August 2020
GET THIS BOOKSystems Medicine

Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and

Personalized Anaesthesia

Personalized Anaesthesia
  • Author : Pedro L. Gambús,Jan F. A. Hendrickx
  • Publisher : Cambridge University Press
  • Release : 31 January 2020
GET THIS BOOKPersonalized Anaesthesia

Presents a modern vision of anaesthesia, integrating technology and knowledge, to change how anaesthesia is taught and practised.

Modeling Evolution of Heterogeneous Populations

Modeling Evolution of Heterogeneous Populations
  • Author : Irina Kareva,Georgy Karev
  • Publisher : Academic Press
  • Release : 16 October 2019
GET THIS BOOKModeling Evolution of Heterogeneous Populations

Modeling Evolution of Heterogeneous Populations: Theory and Applications describes, develops and provides applications of a method that allows incorporating population heterogeneity into systems of ordinary and discrete differential equations without significantly increasing system dimensionality. The method additionally allows making use of results of bifurcation analysis performed on simplified homogeneous systems, thereby building on the existing body of tools and knowledge and expanding applicability and predictive power of many mathematical models. Introduces Hidden Keystone Variable (HKV) method, which allows modeling evolution

A Pharmacology Primer

A Pharmacology Primer
  • Author : Terry Kenakin
  • Publisher : Academic Press
  • Release : 26 October 2018
GET THIS BOOKA Pharmacology Primer

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real

Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine

Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine
  • Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
  • Publisher : National Academies Press
  • Release : 29 May 2018
GET THIS BOOKAdvancing Disease Modeling in Animal-Based Research in Support of Precision Medicine

Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed