Radical and Ion pairing Strategies in Asymmetric Organocatalysis

Considering the challenge of sustainability facing our society in the coming decades, catalysis is without any doubt a research area of major importance. In this regard, asymmetric organocatalysis, now considered a pillar of green chemistry, deserves particular attention. The first chapter of this volume examines the topic of asymmetric organocatalysis in light of radical chemistry. Recent important progress in this field has been attained by promoting the formation and harnessing the high reactivity of open-shell intermediates. Merging organocatalysis with radical chemistry has been the key to solving some longstanding bottlenecks, and has also significantly contributed to reinforcing the key role of organocatalysis in asymmetric catalysis. This chapter presents the most significant developments in this area, with a particular focus on asymmetric SOMO- and photoredox-organocatalyzed transformations. Chapter 2 focuses on quaternary ammonium salts (R4N+X-), especially chiral derivatives, and their behavior as unique catalysts in organocatalysis. Forming chiral ion-pairs capable of promoting asymmetric reactions, they also operate as unique “transporters involved in phase transfer catalytic processes between liquid–liquid or liquid–solid systems. Furthermore, they offer unique opportunities when forming cooperative ion-paired entities R4N+X-, allowing a synergistic implication of the counter-ion X- either as Brønsted bases or Lewis bases. Specific design of such chiral catalysts in modern chemistry and better insight into their mode of activation facilitates efficient and unprecedented chemical transformations. This chapter provides an overview of the use of chiral quaternary ammonium salts in organocatalysis, emphasizing both general mechanistic aspects and the scope of this approach. Presents the most significant developments with a particular focus on asymmetric SOMO- and photoredox-organocatalyzed transformations Givies a larger overview of chiral ammonium salts in organocatalysis rather than a specific review dedicated to specialists in this area Affords a historical evolution of this field of research

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  • Author : Maxime R Vitale
  • Publisher : Elsevier
  • Pages : 184 pages
  • ISBN : 0081011555
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKRadical and Ion pairing Strategies in Asymmetric Organocatalysis

Radical and Ion-pairing Strategies in Asymmetric Organocatalysis

Radical and Ion-pairing Strategies in Asymmetric Organocatalysis
  • Author : Maxime R Vitale,Sylvain Oudeyer,Vincent Levacher,Jean-Francois Briere
  • Publisher : Elsevier
  • Release : 21 July 2017
GET THIS BOOKRadical and Ion-pairing Strategies in Asymmetric Organocatalysis

Considering the challenge of sustainability facing our society in the coming decades, catalysis is without any doubt a research area of major importance. In this regard, asymmetric organocatalysis, now considered a pillar of green chemistry, deserves particular attention. The first chapter of this volume examines the topic of asymmetric organocatalysis in light of radical chemistry. Recent important progress in this field has been attained by promoting the formation and harnessing the high reactivity of open-shell intermediates. Merging organocatalysis with radical

Dienamine Catalysis for Organic Synthesis

Dienamine Catalysis for Organic Synthesis
  • Author : Kengadarane Anebouselvy,Dhevalapally B Ramachary,Indresh Kumar
  • Publisher : Royal Society of Chemistry
  • Release : 02 March 2018
GET THIS BOOKDienamine Catalysis for Organic Synthesis

In the past decade a new era in asymmetric catalysis has been realised by the discovery of L-proline induced chiral enamines from carbonyls. Inspired by this, researchers have developed many other primary catalytic species in situ, more recently secondary catalytic species such as aminals have been identified for use in asymmetric synthesis. High-yielding asymmetric synthesis of bioactive and natural products through mild catalysis is an efficient approach in reaction engineering. In the early days, synthetic chemists mainly focused on the

Recent Advances in Organocatalysis

Recent Advances in Organocatalysis
  • Author : Iyad Karamé,Hassan Srour
  • Publisher : BoD – Books on Demand
  • Release : 28 September 2016
GET THIS BOOKRecent Advances in Organocatalysis

Organocatalysis has recently attracted enormous attention as green and sustainable catalysis. It was realized as a fundamental field providing wide families of catalysts for important organic transformations. It will certainly develop in the future. Given the diversity of accessible transformations, metal-catalyzed reactions have become major tools in organic synthesis that will undoubtedly continue to have an important impact in the future. Alternatively, over the last years, a metal-free approach such as organocatalysis has reached a level of faithfulness, allowing researchers

Asymmetric Organocatalysis Combined with Metal Catalysis

Asymmetric Organocatalysis Combined with Metal Catalysis
  • Author : Bruce A. Arndtsen,Liu-Zhu Gong
  • Publisher : Springer Nature
  • Release : 24 April 2020
GET THIS BOOKAsymmetric Organocatalysis Combined with Metal Catalysis

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific

Efficiency in Natural Product Total Synthesis

Efficiency in Natural Product Total Synthesis
  • Author : Pei-Qiang Huang,Zhu-Jun Yao,Richard P. Hsung
  • Publisher : John Wiley & Sons
  • Release : 20 July 2018
GET THIS BOOKEfficiency in Natural Product Total Synthesis

Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two

Asymmetric Phase Transfer Catalysis

Asymmetric Phase Transfer Catalysis
  • Author : Keiji Maruoka
  • Publisher : John Wiley & Sons
  • Release : 31 March 2008
GET THIS BOOKAsymmetric Phase Transfer Catalysis

Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.

Homogeneous Gold Catalysis

Homogeneous Gold Catalysis
  • Author : LeGrande M. Slaughter
  • Publisher : Springer
  • Release : 30 March 2015
GET THIS BOOKHomogeneous Gold Catalysis

The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each

Catalytic Methods in Asymmetric Synthesis

Catalytic Methods in Asymmetric Synthesis
  • Author : Michelangelo Gruttadauria
  • Publisher : John Wiley & Sons
  • Release : 27 September 2011
GET THIS BOOKCatalytic Methods in Asymmetric Synthesis

"This book covers advances in the methods of catalytic asymmetric synthesis and their applications. Coverage moves from new materials such as chiral ionic liquids, supported catalysts and flow reactors; to homogeneous metal-free catalysts and homogeneous metal catalysts. The applications of several methodologies for the synthesis of biologically active molecules are discussed. Part I addresses recent advances in new technologies related to asymmetric catalysis. Part II covers advances and milestones with amino acids, both natural and unnatural, as powerful organocatalysts -

Cooperative Catalysis

Cooperative Catalysis
  • Author : René Peters
  • Publisher : John Wiley & Sons
  • Release : 27 April 2015
GET THIS BOOKCooperative Catalysis

Written by experts in the field, this is a much–needed overview of the rapidly emerging field of cooperative catalysis. The authors focus on the design and development of novel high–performance catalysts for applications in organic synthesis (particularly asymmetric synthesis), covering a broad range of topics, from the latest progress in Lewis acid / Brønsted base catalysis to e.g. metal–assisted organo catalysis, cooperative metal/enzyme catalysis, and cooperative catalysis in polymerization reactions and on solid surfaces. The

New Organocatalytic Strategies for the Selective Synthesis of Centrally and Axially Chiral Molecules

New Organocatalytic Strategies for the Selective Synthesis of Centrally and Axially Chiral Molecules
  • Author : Nicola Di Iorio
  • Publisher : Springer
  • Release : 11 April 2018
GET THIS BOOKNew Organocatalytic Strategies for the Selective Synthesis of Centrally and Axially Chiral Molecules

This thesis discusses the use of asymmetric organic catalysis for the direct enantioselective synthesis of complex chiral molecules, and by addressing the many aspects of both vinylogy and atropisomerism, it appeals to researchers and scholars interested in both areas. Organocatalysis is a relatively modern and “hot” topic in the chemical community; it is constantly expanding and its use has been extended to interesting areas like vinylogous reactivity and atropisomerism. Vinylogous systems are very important for their synthetic applications but also

Handbook of Synthetic Photochemistry

Handbook of Synthetic Photochemistry
  • Author : Angelo Albini,Maurizio Fagnoni
  • Publisher : John Wiley & Sons
  • Release : 09 December 2009
GET THIS BOOKHandbook of Synthetic Photochemistry

Unique in its focus on preparative impact rather than mechanistic details, this handbook provides an overview of photochemical reactions classed according to the structural feature that is built in the photochemical step, so as to facilitate use by synthetic chemists unfamiliar with this topic. An introductory section covers practical questions on how to run a photochemical reaction, while all classes of the most important photocatalytic reactions are also included. Perfect for organic synthetic chemists in academia and industry.

Asymmetric Organocatalysis

Asymmetric Organocatalysis
  • Author : Benjamin List
  • Publisher : Springer
  • Release : 04 May 2012
GET THIS BOOKAsymmetric Organocatalysis

As nucleophiles, simple alkenes are typically so unreactive that only highly active electrophiles, such as carbocations, peroxides, and halogens will react with them. For the generation of carbon-carbon bonds, milder methods will often be required. Fortunately, it is possible to increase the reactivity of alkene-type p-nucleophiles by introducing electron-donating substituents. Substitution of one H with an OH or OR gives an enol or a vinyl ether, which are already much better nucleophiles. Using nitrogen instead of oxygen, one obtains even

Asymmetric Organocatalysis in Natural Product Syntheses

Asymmetric Organocatalysis in Natural Product Syntheses
  • Author : Mario Waser
  • Publisher : Springer Science & Business Media
  • Release : 30 July 2012
GET THIS BOOKAsymmetric Organocatalysis in Natural Product Syntheses

This book provides the reader with an illustrative overview concerning successful and widely used applications of organocatalysis in the field of natural product synthesis. The main focus will be on organocatalytic key-steps for each (multi-step) synthesis described, whereas other often particularly innovative transformations will be omitted, as this would be beyond the scope of this volume.