Reproducibility in Biomedical Research

Reproducibility in Biomedical Research: Epistemological and Statistical Problems explores the ideas and conundrums inherent in scientific research. It explores factors of reproducibility, including logic, distinguishing productive from unproductive irreproducibility, the scientific method, and the use of statistics. In multiple examples and six detailed case studies, the book demonstrates the misuse of logic resulting in unproductive irreproducibility, allowing researchers to develop their own logic and planning abilities. Biomedical researchers, clinicians, administrators of scientific institutions and funding agencies, journal editors, philosophers of science and medicine will find the arguments and explorations a valuable addition to their libraries. Considers the meaning and purpose of reproducibility to help design research Reviews famous case studies of alleged irreproducibility to determine if these could be reproducible Provides a theoretical aspect to practical issues surrounding research design and conduct

Produk Detail:

  • Author : Erwin B. Montgomery
  • Publisher : Academic Press
  • Pages : 356 pages
  • ISBN : 0128176725
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKReproducibility in Biomedical Research

Reproducibility in Biomedical Research

Reproducibility in Biomedical Research
  • Author : Erwin B. Montgomery
  • Publisher : Academic Press
  • Release : 14 March 2019
GET THIS BOOKReproducibility in Biomedical Research

Reproducibility in Biomedical Research: Epistemological and Statistical Problems explores the ideas and conundrums inherent in scientific research. It explores factors of reproducibility, including logic, distinguishing productive from unproductive irreproducibility, the scientific method, and the use of statistics. In multiple examples and six detailed case studies, the book demonstrates the misuse of logic resulting in unproductive irreproducibility, allowing researchers to develop their own logic and planning abilities. Biomedical researchers, clinicians, administrators of scientific institutions and funding agencies, journal editors, philosophers of

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,National Cancer Policy Forum,Forum on Neuroscience and Nervous System Disorders,Forum on Drug Discovery, Development, and Translation
  • Publisher : National Academies Press
  • Release : 28 May 2020
GET THIS BOOKEnhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their findings in a manner that is understandable to others in the scientific community and provide sufficient information for others to validate the original results and build on them. In recent

Reproducibility and Replicability in Science

Reproducibility and Replicability in Science
  • Author : National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Board on Research Data and Information,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Board on Mathematical Sciences and Analytics,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Reproducibility and Replicability in Science
  • Publisher : National Academies Press
  • Release : 20 October 2019
GET THIS BOOKReproducibility and Replicability in Science

One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of a lack of rigor in science, while others argue that such an observed inconsistency can be an important precursor to new discovery. Concerns about reproducibility and replicability have been expressed

Research in the Biomedical Sciences

Research in the Biomedical Sciences
  • Author : Michael Curtis,Michael Williams
  • Publisher : Academic Press
  • Release : 01 June 2017
GET THIS BOOKResearch in the Biomedical Sciences

Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Enhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,Board on Health Sciences Policy,Roundtable on Genomics and Precision Health,National Cancer Policy Forum,Forum on Neuroscience and Nervous System Disorders,Forum on Drug Discovery, Development, and Translation
  • Publisher : National Academies Press
  • Release : 28 April 2020
GET THIS BOOKEnhancing Scientific Reproducibility in Biomedical Research Through Transparent Reporting

Sharing knowledge is what drives scientific progress - each new advance or innovation in biomedical research builds on previous observations. However, for experimental findings to be broadly accepted as credible by the scientific community, they must be verified by other researchers. An essential step is for researchers to report their findings in a manner that is understandable to others in the scientific community and provide sufficient information for others to validate the original results and build on them. In recent

Rigor Mortis

Rigor Mortis
  • Author : Richard Harris
  • Publisher : Hachette UK
  • Release : 04 April 2017
GET THIS BOOKRigor Mortis

An essential book to understanding whether the new miracle cure is good science or simply too good to be true American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal

Research in the Biomedical Sciences

Research in the Biomedical Sciences
  • Author : Michael Williams,Michael Curtis,Kevin Mullane
  • Publisher : Academic Press
  • Release : 20 October 2017
GET THIS BOOKResearch in the Biomedical Sciences

Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility

Reproducibility in Biomedical Research

Reproducibility in Biomedical Research
  • Author : Erwin B. Montgomery
  • Publisher : Academic Press
  • Release : 15 March 2019
GET THIS BOOKReproducibility in Biomedical Research

Reproducibility in Biomedical Research explores the ideas and conundrums inherent in scientific research. Reproducibility is a significant concern within biomedical research. How can any biomedical researcher be sure her or his research will not be found reproducible or been compromised by the potentially irreproducible work of other scientists on which she or he depends? Within this concern lies the question of multiple types of reproducibility and how research becomes irreproducible. Contributing factors have often been confined to considerations of fraud,

Statistical Challenges in Assessing and Fostering the Reproducibility of Scientific Results

Statistical Challenges in Assessing and Fostering the Reproducibility of Scientific Results
  • Author : National Academies of Sciences, Engineering, and Medicine,Division on Engineering and Physical Sciences,Board on Mathematical Sciences and Their Applications,Committee on Applied and Theoretical Statistics
  • Publisher : National Academies Press
  • Release : 29 March 2016
GET THIS BOOKStatistical Challenges in Assessing and Fostering the Reproducibility of Scientific Results

Questions about the reproducibility of scientific research have been raised in numerous settings and have gained visibility through several high-profile journal and popular press articles. Quantitative issues contributing to reproducibility challenges have been considered (including improper data measurement and analysis, inadequate statistical expertise, and incomplete data, among others), but there is no clear consensus on how best to approach or to minimize these problems. A lack of reproducibility of scientific results has created some distrust in scientific findings among the

The Genetics of Pain

The Genetics of Pain
  • Author : Jeffrey Steven Mogil
  • Publisher : International Assn for the Study of Pain
  • Release : 24 June 2021
GET THIS BOOKThe Genetics of Pain

No field of biology has engendered so much interest, hope, and hype as genetics. Advances in molecular, statistical and behavioral methodologies have suddenly allowed genetic investigations of complex biological phenomena, including pain. Genetic studies of pain are already showing their power to identify new molecular targets for drug development and create new animal models of pain pathology. Alone among biological approaches, pain genetics can explain why we're not all alike with respect to pain - why some people hurt more,

The Practice of Reproducible Research

The Practice of Reproducible Research
  • Author : Justin Kitzes,Daniel Turek,Fatma Deniz
  • Publisher : Univ of California Press
  • Release : 17 October 2017
GET THIS BOOKThe Practice of Reproducible Research

The Practice of Reproducible Research presents concrete examples of how researchers in the data-intensive sciences are working to improve the reproducibility of their research projects. In each of the thirty-one case studies in this volume, the author or team describes the workflow that they used to complete a real-world research project. Authors highlight how they utilized particular tools, ideas, and practices to support reproducibility, emphasizing the very practical how, rather than the why or what, of conducting reproducible research. Part 1

Metabolomics for Biomedical Research

Metabolomics for Biomedical Research
  • Author : Jerzy Adamski
  • Publisher : Academic Press
  • Release : 20 March 2020
GET THIS BOOKMetabolomics for Biomedical Research

Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells

Reproducibility in A.I. for Biomedical Research: an Application to Parkinson's Disease

Reproducibility in A.I. for Biomedical Research: an Application to Parkinson's Disease
  • Author : Christian Lee McDaniel
  • Publisher : Unknown Publisher
  • Release : 24 June 2021
GET THIS BOOKReproducibility in A.I. for Biomedical Research: an Application to Parkinson's Disease

Deep learning-based data analysis techniques have found many uses in biomedical re- search. Recent expansion of open source databases and computational tools has fostered distributed and explorative research. Under these conditions, reproducibil- ity and experimental rigor must be ensured. Developing explicit analysis pipelines exposes the scientific process and yields reproducible results. In this thesis, we look at the case of deep learning-based data analysis for Parkinson's disease (PD) research. We develop end-to-end pipelines in two PD-related fields: accelerometer data analysis

Fostering Integrity in Research

Fostering Integrity in Research
  • Author : National Academies of Sciences, Engineering, and Medicine,Policy and Global Affairs,Committee on Science, Engineering, Medicine, and Public Policy,Committee on Responsible Science
  • Publisher : National Academies Press
  • Release : 13 January 2018
GET THIS BOOKFostering Integrity in Research

The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support â€" or distort â€" practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge. The 1992 report Responsible Science:

Reproducibility

Reproducibility
  • Author : Harald Atmanspacher,Sabine Maasen
  • Publisher : John Wiley & Sons
  • Release : 05 July 2016
GET THIS BOOKReproducibility

A review of the scientific method. In the scientific method, results must be capable of being reproduced to be valid.