Side Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists Covers solid phase and solution phase methodologies, and provides abundant references for further exploration

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  • Author : Yi Yang
  • Publisher : Academic Press
  • Pages : 376 pages
  • ISBN : 0128011815
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKSide Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis
  • Author : Yi Yang
  • Publisher : Academic Press
  • Release : 01 September 2015
GET THIS BOOKSide Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are

Solid-Phase Peptide Synthesis

Solid-Phase Peptide Synthesis
  • Author : Gregg B. Fields
  • Publisher : Academic Press
  • Release : 04 November 1997
GET THIS BOOKSolid-Phase Peptide Synthesis

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of

Chemistry of Peptide Synthesis

Chemistry of Peptide Synthesis
  • Author : N. Leo Benoiton
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKChemistry of Peptide Synthesis

Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather th

Principles of Peptide Synthesis

Principles of Peptide Synthesis
  • Author : Miklos Bodanszky
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKPrinciples of Peptide Synthesis

Principles of Peptide Synthesis is a very successful book by one of the pioneers of contemporary bioorganic synthesis. Its first edition proved a valuable source that is kept close to the work bench for frequent consulting. Any researcher planning the formation of the peptide bond, be it for the synthesis of a peptide chain or a cyclic peptide, benefits from the author's experience. The concise and critical treatment of the steps involved: protection, activation and bond formation require careful planning

Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry

Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry
  • Author : Andrew B. Hughes
  • Publisher : John Wiley & Sons
  • Release : 08 August 2011
GET THIS BOOKAmino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry

This is the third of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric

The Peptides

The Peptides
  • Author : Eberhard Schröder,Klaus Lübke
  • Publisher : Elsevier
  • Release : 12 May 2014
GET THIS BOOKThe Peptides

The Peptides, Volume I: Methods of Peptide Synthesis focuses on detailed description of protecting groups, individual amino acids, and coupling reactions. The publication first offers information on amino-protecting and carboxyl-protecting groups, including carboxyl protection by salt formation, esterification, and amide formation and acyl-type, alkyl-type, and urethane protecting groups. The text then examines the formation of the peptide bond and amino acids. Discussions focus on amino acids with the alcoholic hydroxyl group, sulfur amino acids, basic and acidic amino acids, synthesis

Fmoc Solid Phase Peptide Synthesis

Fmoc Solid Phase Peptide Synthesis
  • Author : W. Chan,Peter White
  • Publisher : OUP Oxford
  • Release : 16 December 1999
GET THIS BOOKFmoc Solid Phase Peptide Synthesis

Since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The focus of this new volume is much broader, and covers the essential procedures.

Chemical Approaches to the Synthesis of Peptides and Proteins

Chemical Approaches to the Synthesis of Peptides and Proteins
  • Author : Paul Lloyd-Williams,Fernando Albericio,Ernest Giralt
  • Publisher : CRC Press
  • Release : 18 August 2020
GET THIS BOOKChemical Approaches to the Synthesis of Peptides and Proteins

Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein

Peptide Synthesis

Peptide Synthesis
  • Author : Waleed M. Hussein,Mariusz Skwarczynski,Istvan Toth
  • Publisher : Humana
  • Release : 10 January 2021
GET THIS BOOKPeptide Synthesis

This book provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is of paramount importance for successful synthesis. Numerous techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative

Principles of Peptide Synthesis

Principles of Peptide Synthesis
  • Author : M. Bodanszky
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKPrinciples of Peptide Synthesis

A look at the shelves of a major library awakens doubts in the author of this small volume about the importance of writing a new introduction to peptide synthesis. This rather narrow area of bio-organic chemistry already has received considerable attention. A whole series of books deals with the synthesis of peptides. Some of these are textbooks written to support lecture courses on peptide synthesis. Others try to help the beginner, otherwise well versed in organic chemistry, to embark on

Chemistry of Peptide Synthesis

Chemistry of Peptide Synthesis
  • Author : N. Leo Benoiton
  • Publisher : CRC Press
  • Release : 12 August 2005
GET THIS BOOKChemistry of Peptide Synthesis

Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author’s role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather than memorization. The text uses clear language and schematics to present concepts progressively, carefully excluding unnecessary details and providing a historical context in which to appreciate the development of

Aspects of the Merrifield Peptide Synthesis

Aspects of the Merrifield Peptide Synthesis
  • Author : C. Birr
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKAspects of the Merrifield Peptide Synthesis

This book was written in the context of the daily confrontation with problems in the utilization of polymeric supports for the synthesis of pep tides. Therefore, views and experiences which usually are not mentioned in scientific journals are collected in these pages. The author has deliberately discussed in detail the possible influence of the polymer phase on the varying reaction conditions in the Merrifield synthesis; this aspect is neglected in most publications dealing with peptide synthesis. However, in view of