Side Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists Covers solid phase and solution phase methodologies, and provides abundant references for further exploration

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  • Author : Yi Yang
  • Publisher : Academic Press
  • Pages : 376 pages
  • ISBN : 0128011815
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKSide Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis
  • Author : Yi Yang
  • Publisher : Academic Press
  • Release : 01 September 2015
GET THIS BOOKSide Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are

Principles of Peptide Synthesis

Principles of Peptide Synthesis
  • Author : Miklos Bodanszky
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKPrinciples of Peptide Synthesis

Principles of Peptide Synthesis is a very successful book by one of the pioneers of contemporary bioorganic synthesis. Its first edition proved a valuable source that is kept close to the work bench for frequent consulting. Any researcher planning the formation of the peptide bond, be it for the synthesis of a peptide chain or a cyclic peptide, benefits from the author's experience. The concise and critical treatment of the steps involved: protection, activation and bond formation require careful planning

Chemistry of Peptide Synthesis

Chemistry of Peptide Synthesis
  • Author : N. Leo Benoiton
  • Publisher : CRC Press
  • Release : 19 April 2016
GET THIS BOOKChemistry of Peptide Synthesis

Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather th

Solid-Phase Peptide Synthesis

Solid-Phase Peptide Synthesis
  • Author : Gregg B. Fields
  • Publisher : Academic Press
  • Release : 04 November 1997
GET THIS BOOKSolid-Phase Peptide Synthesis

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of

Side Reactions in Organic Synthesis

Side Reactions in Organic Synthesis
  • Author : Florencio Zaragoza Dörwald
  • Publisher : John Wiley & Sons
  • Release : 06 March 2006
GET THIS BOOKSide Reactions in Organic Synthesis

Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reactivity relationship of organic compounds. This textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency

Fmoc Solid Phase Peptide Synthesis

Fmoc Solid Phase Peptide Synthesis
  • Author : W. Chan,Peter White
  • Publisher : OUP Oxford
  • Release : 16 December 1999
GET THIS BOOKFmoc Solid Phase Peptide Synthesis

Since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The focus of this new volume is much broader, and covers the essential procedures.

The Peptides

The Peptides
  • Author : Eberhard Schröder,Klaus Lübke
  • Publisher : Elsevier
  • Release : 12 May 2014
GET THIS BOOKThe Peptides

The Peptides, Volume I: Methods of Peptide Synthesis focuses on detailed description of protecting groups, individual amino acids, and coupling reactions. The publication first offers information on amino-protecting and carboxyl-protecting groups, including carboxyl protection by salt formation, esterification, and amide formation and acyl-type, alkyl-type, and urethane protecting groups. The text then examines the formation of the peptide bond and amino acids. Discussions focus on amino acids with the alcoholic hydroxyl group, sulfur amino acids, basic and acidic amino acids, synthesis

Peptide Applications in Biomedicine, Biotechnology and Bioengineering

Peptide Applications in Biomedicine, Biotechnology and Bioengineering
  • Author : Sotirios Koutsopoulos
  • Publisher : Woodhead Publishing
  • Release : 16 November 2017
GET THIS BOOKPeptide Applications in Biomedicine, Biotechnology and Bioengineering

Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work

Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry

Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry
  • Author : Andrew B. Hughes
  • Publisher : John Wiley & Sons
  • Release : 08 August 2011
GET THIS BOOKAmino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry

This is the third of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric

Bioconjugate Techniques

Bioconjugate Techniques
  • Author : Greg T. Hermanson
  • Publisher : Academic Press
  • Release : 25 July 2013
GET THIS BOOKBioconjugate Techniques

Bioconjugate Techniques, 3rd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions, with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers.

Chemistry and Biochemistry of the Amino Acids

Chemistry and Biochemistry of the Amino Acids
  • Author : Graham Barrett
  • Publisher : Springer Science & Business Media
  • Release : 06 December 2012
GET THIS BOOKChemistry and Biochemistry of the Amino Acids

Amino acids are featured in course syllabuses and in project and research work over a wide spectrum of subject areas in chemistry and biology. Chemists and biochemists using amino acids have many common needs when they turn to the literature for comprehensive information. Among these common interests, analytical studies, in particular, have undergone rapid development in recent years. All other chemical and biochemical aspects of amino acids - synthesis, properties and reactions, preparation of derivatives for use in peptide synthesis,

Deamidation and Isoaspartate Formation in Peptides and Proteins

Deamidation and Isoaspartate Formation in Peptides and Proteins
  • Author : Dana W. Aswad
  • Publisher : CRC Press
  • Release : 17 June 1995
GET THIS BOOKDeamidation and Isoaspartate Formation in Peptides and Proteins

As the biotechnology industry provides an increasing number of protein-based pharmaceuticals, it is important to understand the sources of heterogeneity and instability of purified proteins. Deamidation and Isoaspartate Formation in Peptides and Proteins focuses exclusively on these topics. It provides a comprehensive presentation of the mechanisms and conditions that lead to deamidation and isoaspartate formation, the effect of protein structure on the susceptibility of proteins to these reactions, the functional consequences of these reactions, and methodology that can be used