Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Produk Detail:

  • Author : Brian J Arey
  • Publisher : Elsevier
  • Pages : 316 pages
  • ISBN : 0124115071
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKBiased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics
  • Author : Brian J Arey
  • Publisher : Elsevier
  • Release : 05 June 2014
GET THIS BOOKBiased Signaling in Physiology, Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate

Regulation of Signal Transduction in Human Cell Research

Regulation of Signal Transduction in Human Cell Research
  • Author : Nariyoshi Shinomiya,Hiroaki Kataoka,Qian Xie
  • Publisher : Springer
  • Release : 15 February 2018
GET THIS BOOKRegulation of Signal Transduction in Human Cell Research

This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have

Signal Transduction

Signal Transduction
  • Author : Lewis C Cantley,Tony Hunter,Jeremy Thorner,Richard Sever
  • Publisher : Unknown Publisher
  • Release : 31 October 2013
GET THIS BOOKSignal Transduction

Cells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex network of signal transduction pathways within the cell ensures that these signals are relayed to the correct molecular targets and that the cell responds appropriately. This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. Taking a novel approach,

Molecular Pathogenesis and Signal Transduction by Helicobacter pylori

Molecular Pathogenesis and Signal Transduction by Helicobacter pylori
  • Author : Nicole Tegtmeyer,Steffen Backert
  • Publisher : Springer
  • Release : 23 January 2017
GET THIS BOOKMolecular Pathogenesis and Signal Transduction by Helicobacter pylori

This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori, which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of

Hormonal Signaling in Biology and Medicine

Hormonal Signaling in Biology and Medicine
  • Author : Gerald Litwack
  • Publisher : Academic Press
  • Release : 24 October 2019
GET THIS BOOKHormonal Signaling in Biology and Medicine

Hormonal Signaling in Biology and Medicine: Comprehensive Modern Endocrinology covers the endocrine secretions produced by every organ. This extensive collection of knowledge is organized by tissue, addressing how certain hormones are synthesized in multiple tissues, along with their structure, function and pathways, which are very applicable for researchers in drug design who need to focus on a specific step along the pathway. This is a must have reference for researchers in endocrinology and practicing endocrinologists, but it is also ideal

Handbook of Cell Signaling

Handbook of Cell Signaling
  • Author : Ralph A. Bradshaw,Edward A. Dennis
  • Publisher : Academic Press
  • Release : 03 November 2009
GET THIS BOOKHandbook of Cell Signaling

Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad,

Physiology and Pathophysiology of the Heart

Physiology and Pathophysiology of the Heart
  • Author : Nick Sperelakis,Nicholas Sperelakis
  • Publisher : Springer
  • Release : 14 April 1995
GET THIS BOOKPhysiology and Pathophysiology of the Heart

The third edition includes 14 new chapters covering topics that were not covered in the second edition. These include two new chapters on the molecular structure of ion channels and several new chapters on the ionic channels of myocardial cells, vascular smooth muscle cells, and endothelial cells. New chapters are also included on release of Ca[superscript 2+] from the SR, and on the action of phospholipids released during ischemia on ion channels and production of disrhythmias. These new additions make Physiology

Sex Differences in Cardiovascular Physiology and Pathophysiology

Sex Differences in Cardiovascular Physiology and Pathophysiology
  • Author : Babbette LaMarca, Ph.D.,Barbara T. Alexander, PhD, FAHA, FAPS
  • Publisher : Academic Press
  • Release : 15 June 2019
GET THIS BOOKSex Differences in Cardiovascular Physiology and Pathophysiology

Sex Differences in Cardiovascular Physiology and Pathophysiology is a comprehensive look into the often overlooked and underappreciated fundamental sex differences between men and women and how those differences affect the cardiovascular system. It covers cardiovascular function, anatomy, cell signaling and the development of pathology. With contributions from world-renowned research investigators, this up-to-date reference compiles critical knowledge on cardiovascular sex differences, providing researchers and clinicians with a better understanding of the diagnosis, prevention and treatment of cardiovascular diseases in both men

Pain and Disability

Pain and Disability
  • Author : Institute of Medicine,Committee on Pain, Disability, and Chronic Illness Behavior
  • Publisher : National Academies Press
  • Release : 01 January 1987
GET THIS BOOKPain and Disability

Pain--it is the most common complaint presented to physicians. Yet pain is subjective--it cannot be measured directly and is difficult to validate. Evaluating claims based on pain poses major problems for the Social Security Administration (SSA) and other disability insurers. This volume covers the epidemiology and physiology of pain; psychosocial contributions to pain and illness behavior; promising ways of assessing and measuring chronic pain and dysfunction; clinical aspects of prevention, diagnosis, treatment, and rehabilitation; and how the SSA's benefit structure