Sirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery fills a significant void that provides a unique resource for elucidating the most recent research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities. Scientists, physicians, students and pharmaceutical industry researchers from diverse backgrounds will use this reference as the "go-to resource” for both the biology and medical applications that focus upon sirtuins. As sirtuins play an intricate role in the pathology, progression and treatment of several disease entities ranging from metabolic disease and diabetes, cancer, cardiovascular disease, immune system dysfunction, to reproductive dysfunction, and aging-related disorders, this book provides an ideal update on the topic. Details the basic and clinical role of sirtuins and their broad applicability for sirtuin biology to be targeted for multiple medical disease entities Elucidates the research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities Summarizes the multi-discipline views and publications for this diverse topic, covering cell development, cancer and metabolism

Produk Detail:

  • Author : Kenneth Maiese
  • Publisher : Academic Press
  • Pages : 300 pages
  • ISBN : 0128224673
  • Rating : 4/5 from 21 reviews
CLICK HERE TO GET THIS BOOKSirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease
  • Author : Kenneth Maiese
  • Publisher : Academic Press
  • Release : 19 March 2021
GET THIS BOOKSirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery fills a significant void that provides a unique resource for elucidating the most recent research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities. Scientists, physicians, students and pharmaceutical industry researchers from diverse backgrounds will use this reference as the "go-to resource” for both the biology and medical applications

Sirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease
  • Author : Kenneth Maiese
  • Publisher : Elsevier
  • Release : 20 February 2021
GET THIS BOOKSirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves

Sirtuin Biology in Medicine

Sirtuin Biology in Medicine
  • Author : Kenneth Maiese
  • Publisher : Academic Press
  • Release : 04 March 2021
GET THIS BOOKSirtuin Biology in Medicine

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during

Introductory Review on Sirtuins in Biology, Aging, and Disease

Introductory Review on Sirtuins in Biology, Aging, and Disease
  • Author : Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev
  • Publisher : Academic Press
  • Release : 20 April 2018
GET THIS BOOKIntroductory Review on Sirtuins in Biology, Aging, and Disease

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus,

Sirtuins in Biology and Disease

Sirtuins in Biology and Disease
  • Author : Tiago F. Outeiro,Aleksey G. Kazantsev
  • Publisher : Frontiers E-books
  • Release : 01 July 2022
GET THIS BOOKSirtuins in Biology and Disease

Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high,

Sirtuins

Sirtuins
  • Author : Riekelt H. Houtkooper
  • Publisher : Springer
  • Release : 17 November 2016
GET THIS BOOKSirtuins

The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects

Histone Deacetylases: the Biology and Clinical Implication

Histone Deacetylases: the Biology and Clinical Implication
  • Author : Tso-Pang Yao,Edward Seto
  • Publisher : Springer Science & Business Media
  • Release : 31 August 2011
GET THIS BOOKHistone Deacetylases: the Biology and Clinical Implication

The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Sirtuins in Health and Disease

Sirtuins in Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release : 03 February 2018
GET THIS BOOKSirtuins in Health and Disease

Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington’s Disease (HD) pathology, parasite sirtuins

The Heterogeneity of Cancer Metabolism

The Heterogeneity of Cancer Metabolism
  • Author : Anne Le
  • Publisher : Springer
  • Release : 26 June 2018
GET THIS BOOKThe Heterogeneity of Cancer Metabolism

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the

Molecular Biology of Aging

Molecular Biology of Aging
  • Author : Leonard Guarente,Linda Partridge,Douglas C. Wallace
  • Publisher : CSHL Press
  • Release : 01 July 2022
GET THIS BOOKMolecular Biology of Aging

This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

Mitochondrial Signaling in Health and Disease

Mitochondrial Signaling in Health and Disease
  • Author : Sten Orrenius,Lester Packer,Enrique Cadenas
  • Publisher : CRC Press
  • Release : 20 June 2012
GET THIS BOOKMitochondrial Signaling in Health and Disease

Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses

Mechanism-based Peptidic and Peptideomimetic Human Sirtuin Inhibitors

Mechanism-based Peptidic and Peptideomimetic Human Sirtuin Inhibitors
  • Author : Brett Hirsch
  • Publisher : Unknown Publisher
  • Release : 01 July 2022
GET THIS BOOKMechanism-based Peptidic and Peptideomimetic Human Sirtuin Inhibitors

"Silent information regulator 2 (Sir2) enzymes or sirtuins are a family of intracellular protein deacetylases that can catalyze the [beta]-nicotinamide adenine dinucleotide ([beta]-NAD+)-dependent deacetylation of N[epsilon]-acetyl-lysine on protein substrates. These enzymes are evolutionarily conserved among all the three kingdoms of life, with the yeast Sir2 being the founding family member. In humans, seven sirtuins, SIRT1-7, have been identified. Protein acetylation/deacetylation plays a critical role in biological processes such as metabolism, gene transcription, neurodegeneration, apoptosis,

Advances in Host-Directed Therapies Against Tuberculosis

Advances in Host-Directed Therapies Against Tuberculosis
  • Author : Petros C. Karakousis,Richard Hafner,Maria Laura Gennaro
  • Publisher : Springer Nature
  • Release : 03 December 2020
GET THIS BOOKAdvances in Host-Directed Therapies Against Tuberculosis

This book discusses specific immune cell regulatory pathway(s), immune cell types, or other mechanisms involved in host responses to tuberculosis that can be potentially targeted for host-directed therapy (HDT). The pathways/mechanisms investigated are either protective – thus calling for pathway/factor enhancing drugs – or maladaptive – thus calling for pathway/factor inhibitory drugs. Discovery and development (pre-clinical and clinical) of candidate HDT agents will also be elucidated, as well as approaches for HDT of other diseases. The benefit to the

Handbook of the Biology of Aging

Handbook of the Biology of Aging
  • Author : Matt Kaeberlein,George Martin
  • Publisher : Academic Press
  • Release : 20 August 2015
GET THIS BOOKHandbook of the Biology of Aging

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to

Epigenetics and Dermatology

Epigenetics and Dermatology
  • Author : Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
  • Publisher : Academic Press
  • Release : 16 February 2015
GET THIS BOOKEpigenetics and Dermatology

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities